In some cases of fatalities involving opioid use,the concentrations of detected opioids are not in the toxic range.Immune reactions can be triggered by opioid use,suggesting that immune response may be a factor in the...
Increasing numbers of veterans are returning home with chronic pain and mental health disorders. Pharmacological treatments may be effective, but may also be increasing the incidence of poisonings among younger as wel...
The incidence of prescription opioid misuse in Canada is increasing. Initiatives for safe prescribing practices for opioid medications include risk assessment for current and future opioid misuse. A clinical screening...
Normal aging is a process that involves loss of functional reserve of most organ systems of the human body, most significantly: cardiovascular, pulmonary, renal and nervous systems. Advancements in both surgery and an...
was supported by grants 08KJB350002 and 08NMUZ028;in part by the Intramural Research Program of the NIH and NIEHS
Analogues of endomorphin and tripeptidcs modified at positions 4 and 3,respectively,with various phenylalanine analogues were synthesized and their affinities for opioid receptors were evaluated.Most of the peptides e...