METHYLTRANSFERASES

作品数：16被引量：28H指数：3
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相关领域：生物学更多>>
相关作者：吴韦韦庞秋香邓玉林魏玉霞肖盛元更多>>
相关机构：深圳大学山东理工大学北京理工大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Science Bulletin》《Signal Transduction and Targeted Therapy》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山东省高等学校科技计划项目山东省自然科学基金更多>>
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Novel insights into histone lysine methyltransferases in cancer therapy:From epigenetic regulation to selective drugs被引量：1
《Journal of Pharmaceutical Analysis》2023年第2期127-141,共15页Qili Liao Jie Yang Shengfang Ge Peiwei Chai Jiayan Fan Renbing Jia 
the Science and Technology Commission of Shanghai,China(Grant Nos.:20DZ2270800 and 19JC1410200);Innovative Research Team of High-Level Local Universities in Shanghai,China(Grant No.:SHSMU-ZDCX20210900);the National Natural Science Foundation of China(Grant No.:82073889).
The reversible and precise temporal and spatial regulation of histone lysine methyltransferases(KMTs)is essential for epigenome homeostasis.The dysregulation of KMTs is associated with tumor initiation,metastasis,chem...
关键词：Cancer EPIGENETICS Histone lysine methyltransferase Epigenetic inhibitors Combined therapeutic strategy Clinical application 
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications被引量：1
《Protein & Cell》2023年第3期165-179,共15页Yanjing Li Kexue Gei Tingting Li Run Cai Yong Chen 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37010303 to Y.C.);the National Natural Science Foundation of China(31670748,31970576 to Y.C.,and 32071195 and 31900934 to Y.L.);the Young Elite Scientist Sponsorship Program by Chinese Association for Science and Technology(YESS20170198 to Y.L.);the National Postdoctoral Program for Innovative Talents(Bx201700263 to Y.L.).
Histone lysine methyltransferases(HKMTs)deposit methyl groups onto lysine residues on histones and play important roles in regulating chromatin structure and gene expression.The structures and functions of HKMTs have ...
关键词：NUCLEOSOME cryo-EM structures histone methyltransferases epigenetics histone methylation TUMORIGENESIS 
Histone lysine methyltransferases as anti-cancer targets for drug discovery被引量：3
《Acta Pharmacologica Sinica》2016年第10期1273-1280,共8页Qing LIU Ming-wei WANG 
Acknowledgements We gratefully acknowledge the financial support from the National Health and Family Planning Commission （2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001, 2013ZX09507-002, and 2014ZX09507002-001）, the National Natural Science Foundation of China （21302202）, Shanghai Science and Technology Development Fund （15DZ2291600）, and the Thousand Talents Program in China.
Post-translational epigenetic modification of histones is controlled by a number of histone-modifying enzymes. Such modification regulates the accessibility of DNA and the subsequent expression or silencing of a gene....
关键词：histone methyltransferases adenosylmethionine small molecule inhibitors anti-cancer drugs epigenetic modification drugdiscovery 
Molecular mechanism for activityregulation of MLL-family methyltransferases
《Science Foundation in China》2016年第1期16-,共1页
With the support by the National Natural Science Foundation of China,the Chinese Academy of Sciences,the Ministry of Science and Technology of China,and the Basic Research Project of Shanghai Science and Technology Co...
关键词：Figure conformational unprecedented LEUKEMIA HISTONE CONSERVED biochemical universal HISTONE inherent 
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