METHYLTRANSFERASES

作品数：16被引量：28H指数：3
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相关领域：生物学更多>>
相关作者：吴韦韦庞秋香邓玉林魏玉霞肖盛元更多>>
相关机构：深圳大学山东理工大学北京理工大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Science Bulletin》《Signal Transduction and Targeted Therapy》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山东省高等学校科技计划项目山东省自然科学基金更多>>
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Methylation in hangtaimycin biosynthesis and its antibacterial activities
《Synthetic and Systems Biotechnology》2023年第4期682-687,共6页Minghe Luo Yulu Dong Zixin Deng Yuhui Sun 
supported by National Key R&D Program of China(2018YFA0903200);General Program of National Natural Science Foundation of China(32370083);Natural Science Foundation of Chongqing CSTB(CSTB2022NSCQ-MSX0995);Graduate Innovation Program(GZLCX20232114)。
About two-thirds of small molecule drugs contain methyl group and it plays a very important role in the drug development.So,methyltransferases catalyzing the methylation have always attracted great attention.Hangtaimy...
关键词：Hangtaimycin METHYLATION S-Adenosylmethionine-dependent METHYLTRANSFERASES FK506 methyltransferase type O-methyltransferase Antibacterial BIOSYNTHESIS 
Novel insights into histone lysine methyltransferases in cancer therapy:From epigenetic regulation to selective drugs被引量：1
《Journal of Pharmaceutical Analysis》2023年第2期127-141,共15页Qili Liao Jie Yang Shengfang Ge Peiwei Chai Jiayan Fan Renbing Jia 
the Science and Technology Commission of Shanghai,China(Grant Nos.:20DZ2270800 and 19JC1410200);Innovative Research Team of High-Level Local Universities in Shanghai,China(Grant No.:SHSMU-ZDCX20210900);the National Natural Science Foundation of China(Grant No.:82073889).
The reversible and precise temporal and spatial regulation of histone lysine methyltransferases(KMTs)is essential for epigenome homeostasis.The dysregulation of KMTs is associated with tumor initiation,metastasis,chem...
关键词：Cancer EPIGENETICS Histone lysine methyltransferase Epigenetic inhibitors Combined therapeutic strategy Clinical application 
Targeting H3K36 methyltransferases NSDs:a promising strategy for tumor targeted therapy
《Signal Transduction and Targeted Therapy》2021年第7期1933-1934,共2页Xuerun Peng Qian Peng Lei Zhong 
This work was supported by the National Natural Science Foundation of China(81702286);the Research Fund of Science&Technology Department of Sichuan Province(2021YJ0134,2018JY0652);the Open Project of Radiation Oncology Key Laboratory of Sichuan Province(2020FSZLX04).
Recently,two studies published in Nature identified genetic changes in the nuclear receptor-binding SET domain protein(NSD)family of histone methyltransferases as oncogenic drivers in some malignancies,and revealed th...
关键词：METHYLTRANSFERASE TARGETED THERAPY 
Molecular Evolution of the Substrate Specificity of Chloroplastic Aldolases/Rubisco Lysine Methyltransferases in Plants
《Molecular Plant》2016年第4期569-581,共13页Sheng Ma Jacqueline Martin-Laffon Morgane Mininno Oceane Gigarel Sabine Brugiere Olivier Bastien Marianne Tardift Stephane Ravanel Claude Alban 
Rubisco and fructose-1,6-bisphosphate aldolases （FBAs） are involved in CO2 fixation in chloroplasts. Both enzymes are trimethylated at a specific lysine residue by the chloroplastic protein methyltransferase LSMT. G...
关键词：SET-domain protein methyltransferase site-directed mutagenesis chimeric enzyme methylation molecular evolution green lineage 
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