KNOCK-DOWN

作品数：15被引量：23H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：魏泓赵从刘勤庞浩刘昌峨更多>>
相关机构：第三军医大学西南大学青岛大学北京工商大学更多>>
相关期刊：《World Journal of Engineering and Technology》《Neuroscience Bulletin》《Journal of Chinese Pharmaceutical Sciences》《Acta Biochimica et Biophysica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金国家高技术研究发展计划更多>>
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Injuries Associated with Auto-Tricycle Crashes in an African City: Incidence and Pattern
《Open Journal of Orthopedics》2024年第5期229-246,共18页Augustus Nii Kwame Okleme David Anyitey-Kokor Dominic Konadu-Yeboah Adam Gyedu Kwabena Agbedinu Johathan Boakye 
Purpose: The aim of this study was to determine the incidence and pattern of injuries resulting from auto-tricycle crashes among patients in a tertiary referral centre in Ghana. Methods: Data were retrospectively extr...
关键词：Auto-Tricycle KNOCK-DOWN RICKSHAW Road Traffic Crashes 
Identification and characterization of Letm1 gene in Toxoplasma gondii被引量：1
《Acta Biochimica et Biophysica Sinica》2019年第1期78-87,共10页Le Chang Xichen Zhang Pengtao Gong Yuru Wang Boya Du Jianhua Li 
Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis.Previous studies have shown that the perturbation of mitochondrial metabolism in T.gondii results in growth deficiency in host cells a...
关键词：T. GONDII Letm1 MITOCHONDRIA SUBCELLULAR LOCALIZATION KNOCK-DOWN FUNCTIONS 
Comparative assessment of the thermal tolerance of spotted stemborer, Chilo partellus （Lepidoptera： Crambidae） and its larval parasitoid, Cotesia sesamiae （Hymenoptera： Braconidae）被引量：1
《Insect Science》2018年第5期847-860,共14页Reyard Mutamiswa Frank Chidawanyika Casper Nyamukondiwa 
Under stressful thermal environments, insects adjust their behavior and physi- ology to maintain key life-history activities and improve survival. For interacting species, mutual or antagonistic, thermal stress may af...
关键词：chill-coma recovery time climate change critical thermal limits heat knock-down time lethal temperatures supercooling point 
RUVBL2基因knock-down对Rad51和γ-H2AX foci的影响被引量：1
《科技资讯》2017年第2期200-202,共3页韩潆仪 
用脂质体转染的方法将特定的RUVBL2 si RNA序列转染到真核细胞,并鉴定其在人肺纤维细胞(MRC5 SV)中的表达,以确保RUVBL2基因的knock-down效果。用Rad51和γ-H2AX的特异性抗体进行免疫荧光染色,应用荧光显微镜观察计数Rad51和γ-H2AX foc...
关键词：RUVBL2 SIRNA RAD51 Γ-H2AX FOCI 
Post-Buckling Behavior of Laminated Composite Cylindrical Shells Subjected to Axial, Bending and Torsion Loads被引量：1
《World Journal of Engineering and Technology》2015年第4期185-194,共10页Yengula Venkata Narayana Jagadish Babu Gunda Ravinder Reddy Pinninti Markandeya Ravvala 
In present work, post-buckling behavior of imperfect (of eigen form) laminated composite cylindrical shells with different L/D and R/t ratios subjected to axial, bending and torsion loads has been investigated by usin...
关键词：POST-BUCKLING Cylindrical Shells Eigen IMPERFECTION Shapes AXIAL Compressive LOAD BENDING LOAD Torsion LOAD Arc-Length Method KNOCK-DOWN Factor 
Development of a high-content screening method to evaluate the cellular population-based biological activity of new siRNA delivering reagent
《Journal of Chinese Pharmaceutical Sciences》2013年第6期467-474,共8页李雅婷 郑宜 潘德林 徐波 武芸 杨振军 张礼和 
Ministry of Science and Technology of China(Grant No.2012CB720604);NSFC(Grant No.20932001)
Normally, cellular responses to modified siRNAs or new siRNA delivery systems have been studied in group cell behavior by PCR, western blotting and fluorescence microscopy. In this study, we present a novel high-conte...
关键词：High-content screening siRNA delivery system Gene knock-down Cellular population ERK signaling pathway 
RNAi-mediated knock-down of Dab and Numb attenuate Ab levels via g-secretase mediated APP processing
《Translational Neurodegeneration》2012年第1期45-54,共10页Zhongcong Xie Yuanlin Dong Uta Maeda Weiming Xia Rudolph E Tanzi 
This research was supported by K08NS048140,R21AG029856,R21AG038994 and R01 GM088801(National Institutes of Health),USA,Jahnigen Career Development Award(American Geriatrics Society),USA;Investigator Initiated Research Grant(Alzheimer’s Association),Cure Alzheimer’s Fund,USA(to Z.X.);MH 60009(National Institute of Mental Health),USA,Cure Alzheimer’s Fund(to R.T.).
Amyloid-b-protein(Ab),the key component of senile plaques in Alzheimer’s disease(AD)brain,is produced from amyloid precursor protein(APP)by cleavage of b-secretase and then g-secretase.APP adaptor proteins with phosp...
关键词：APP IMPAIRED ATTRACTIVE 
Knock-down of postsynaptic density protein 95 expression by antisense oligonucleotides protects against apoptosis-like cell death induced by oxygen-glucose deprivation in vitro被引量：1
《Neuroscience Bulletin》2012年第1期69-76,共8页Jing-Zhi Yan Yong Liu Yan-Yan Zong Guang-Yi Zhang 
supported by the National Natural Science Foundation of China (30170220);Xuzhou Science and Technology Bureau of China (XZZD1157);Xuzhou Medical College (2011KJZ03);A Project Funded by the Priority Academic Program Development of Jingsu Higher Education Institutions
Objective Postsynaptic density protein 95 （PSD-95） plays important roles in the regulation of glutamate signaling, such as that of N-methyl-D-aspartate receptors （NMDARs）. In this study, the functional roles of PS...
关键词：postsynaptic density protein 95 N-methyl-D-aspartate receptor oxygen-glucose deprivation tyrosine phos-phorylation SRC cortical neurons 
Knock-down of protein L-isoaspartyl O-methyltrans- ferase increases β-amyloid production by decreasing ADAMIO and ADAM17 levels被引量：1
《Acta Pharmacologica Sinica》2011年第3期288-294,共7页Narkhyun BAE Se Eun BYEON Jihyuk SONG Sang-Jin LEE Moosik KWON Inhee MOOK-JUNG Jae Youl CHO Sungyoul HONG 
Aim： To examine the role of protein L-isoaspartyl O-methyltransferase （PIMT; EC 2.1.1.77） on the secretion of Aβ peptides. Methods： HEK293 APPsw cells were treated with PIMT siRNA or adenosine dialdehyde （AdOX）...
关键词：Alzheimer＇s disease β-amyloid protein L-isoaspartyl O-methyltransferase soluble amyloid precursor protein alpha ADAMIO ADAM 17 
Production of transgenic mice by random recombination of targeted genes in female germline stem cells
《Journal of Molecular Cell Biology》2011年第2期132-141,共10页Yong Zhang Zhaojuan Yang Yunze Yang Shuzeng Wang Lingjun Shi Wenhai Xie Kejing Sun Kang Zou Lei Wang Ji Xiong Jie Xiang Ji Wu 
This work was supported by the Key Program and the Major Research Plan of the National Natural Science Foundation of China(30630012 and 90919020 to J.W.);National Basic Research Program of China(2010CB945001 and 2011CB965104);Ministry of Agriculture of the People’s Republic of China(2009ZX08006-010B);Program of Shanghai Subject Chief Scientist(10XD1402200 to J.W.);the Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP)in China(20090073110032 to J.W.).
Oocyte production in most mammalian species is believed to cease before birth.However,this idea has been challenged with the finding that postnatal mouse ovaries possess mitotically active germ cells.A recent study sh...
关键词：female germline stem cells GENE-TRANSFER KNOCK-DOWN Oocyte-G1 mouse dynein axonemal intermediate chain 2(Dnaic2) 
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