VORINOSTAT

作品数：11被引量：28H指数：4
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相关作者：孙铁民张兴锴徐文方焦杰马晓黎更多>>
相关机构：沈阳药科大学山东大学华中科技大学中国科学院更多>>
相关期刊：《国际妇产科学杂志》《Journal of Cancer Therapy》《Acta Pharmacologica Sinica》《中国药物化学杂志》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划北京市科技新星计划重庆市自然科学基金更多>>
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Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
《Acta Pharmacologica Sinica》2024年第6期1305-1315,共11页Bing-bing Hao Ke Ma Jun-yu Xu Ru-feng Fan Wen-si Zhao Xing-long Jia Lin-hui Zhai SangKyu Lee Dong Xie Min-jia Tan 
supported by the National Natural Science Foundation of China(32071432,32171434,82272943,32322048);the Youth Science and Technology Talents in Shanghai Sail Plan of China(21YF1456000);Young Elite Scientists Sponsorship Program by CAST(2022QNRC001);Shanghai Rising-Star Program(22QA1411100);the Youth Innovation Promotion Association(CAS2021276);the Sanofi Scholarship Program,Shanghai Committee of Science and Technology,China(21Y11913400);Guangdong High-level New R&D Institute,China(2019B090904008);Guangdong High-level Innovative Research Institute,China(2021B0909050003).
Histone deacetylase inhibitors(HDACis)are important drugs for cancer therapy,but the indistinct resistant mechanisms of solid tumor therapy greatly limit their clinical application.In this study we conducted HDACi-per...
关键词：solid tumor histone deacetylase inhibitor vorinostat(SAHA) drug resistance PROTEOMICS 
Histone Deacetylase Inhibitors Romidepsin and Vorinostat Promote Hepatitis B Virus Replication by Inducing Cell Cycle Arrest被引量：3
《Journal of Clinical and Translational Hepatology》2021年第2期160-168,共9页Yang Yang Yu Yan Zhen Chen Jie Hu Kai Wang Ni Tang Xiaosong Li Zhi Zhou 
This study was supported by the National Natural Science Foundation of China(81871653,82072286 and 82073251);Natural Science Foundation of Chongqing(cstc2020jcyj-msx mX0159,cstc2018jcyjAX0254 and cstc2019jcyj-msxmX0587);Chongqing Medical Science Project(2018MSXM065);Technology Research Project of Chongqing Municipal Education Commission(KJQN201900449;KJZD-M202000401);Scientific Research Innovation Project for Postgraduates in Chongqing(CYS19193 and CYB19168).
Background and Aims:Chronic hepatitis B virus(HBV)infection is a global public health challenge.HBV reactivation usually occurs in cancer patients after receiving cytotoxic chemotherapy or immunosuppressive therapies....
关键词：HBV reactivation Histone deacetylase inhibitor ROMIDEPSIN VORINOSTAT Cell cycle 
Discovery of ErbB/HDAC inhibitors by combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285
《Chinese Chemical Letters》2017年第6期1220-1227,共8页Chao Ding Dan Li Yan-Wei Wang Sai-Sai Han Chun-Mei Gao Chun-Yan Tan Yu-Yang Jiang 
supported by funding from the National Natural Science Foundation of China(No.21272134);Shenzhen Municipal Government(No.CXB201104210014A and20150113A0410006)
By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives...
关键词：Anticancer Kinase HDAC Multitarget Selectivity 
黏附分子CD146对Vorinostat诱导卵巢癌细胞凋亡作用的影响被引量：4
《国际妇产科学杂志》2016年第6期690-694,共5页马晓黎 刘雨声 阎锡蕴 郭银树 段华 马丁 
国家自然科学基金(81101970);北京市科技新星计划(Z141107001814015);北京市医管局重点医学发展项目扬帆计划(ZYLX201406)
目的:探讨黏附分子CD146对组蛋白去乙酰化酶抑制剂Vorinostat诱导卵巢癌细胞凋亡作用的影响。方法:通过实时聚合酶链反应(real-time PCR)和蛋白质印迹(western blotting)法检测卵巢癌细胞A2780和SKOV3中CD146在组蛋白去乙酰化酶抑制剂Vo...
关键词：卵巢肿瘤 抗原 CD146 抗肿瘤药 VORINOSTAT 细胞凋亡 协同作用 
Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells被引量：3
《Acta Biochimica et Biophysica Sinica》2014年第6期484-491,共8页Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi 
This work was supported by grants from the National Natural Science Foundation of China （81372391, 81071856, 81228016, and 81250110552）, Shanghai Science and Technology Program （12410705100）, and Shanghai Tenth People＇s Hospital Funds （040113015）.
In the present study, we investigated the interactions between proteasome inhibitor carfllzomib （CFZ） and histone deacety lase inhibitor vorinostat in Jurkat Tleukemia ceils. Coexposure of cells to minimally lethal ...
关键词：carfilzomib VORINOSTAT reactive oxygenspecies APOPTOSIS JURKAT 
Intravesical Treatment with Vorinostat Can Prevent Tumor Progression in MNU Induced Bladder Cancer
《Journal of Cancer Therapy》2013年第6期1-6,共6页Degui Wang Siwei Ouyang Yingxia Tian Yan Yang Bo Li Xiangwen Liu Yanfeng Song 
Background: Histone deacetylase inhibitors (HDACI) are promising class of drugs acting as antiproliferative agents by promoting differentiation as well as inducing apoptosis. Vorinostat (suberoylanilide hydroxamic aci...
关键词：VORINOSTAT Apoptosis Combination BLADDER Cancer Therapy 
Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo被引量：4
《Acta Pharmacologica Sinica》2013年第5期699-709,共11页Song XU Kim DE VEIRMAN Holly EVANS Gaia Cecilia SANTINI Isabelle VANDE BROEKI XavierLELEU Ann DEBECKER Ben VAN CAMP Peter CROUCHER Karin VANDERKERKEN Ivan VAN RIET 
Vorinostat, a histone deacetylase （HDAC） inhibitor currently in a clinical phase III trial for multiple myeloma （MM） patients, has been reported to cause bone loss. The purpose of this study was to test whether, a...
关键词：histone deacetylase （HDAC） VORINOSTAT mesenchymal stem cell OSTEOGENESIS alkaline phosphatase （ALP） Runx2 OSTEOCALCIN multiple myeloma 
组蛋白去乙酰化酶抑制剂类抗癌药Vorinostat被引量：3
《化工中间体》2009年第6期11-14,共4页黄小平 徐江 
vorinostat属于组蛋白去乙酰化酶抑制剂类抗肿瘤药物,组蛋白去乙酰化酶抑制剂(histone deacetylases inhibitors,HDACIs)是一类在转录水平调控基因表达的化合物,HDACIs能够引起肿瘤细胞生长停滞,诱导肿瘤细胞分化和凋亡。vorinostat就...
关键词：VORINOSTAT SAHA 组蛋白去乙酰化酶抑制剂 合成 
抗肿瘤药Vorinostat的合成被引量：7
《中国医药工业杂志》2009年第2期86-87,共2页焦杰 徐文方 
国家科技部863专项研究课题(2007AA02Z314)
以辛二酸为原料,通过连续两步混合酸酐法制得抗肿瘤药vorinostat,总收率约62%。
关键词：VORINOSTAT 抗肿瘤药 组蛋白脱乙酰酶抑制剂 合成 
治疗皮肤癌新药vorinostat被引量：10
《中国药物化学杂志》2007年第4期268-268,共1页张兴锴 孙铁民 
关键词：药物治疗 皮肤癌 组蛋白脱乙酰基酶 皮肤T淋巴细胞瘤 Merck公司 新药 美国FDA 抗癌药物 
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