GLUCOKINASE

作品数：25被引量：54H指数：4
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相关机构：北京协和医学院军医进修学院首都医科大学附属北京儿童医院中国人民解放军总医院更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Diabetes》《American Journal of Plant Sciences》《World Journal of Hepatology》更多>>
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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
《Military Medical Research》2024年第5期643-662,共20页Hang Xu Yi-Fan Li Xian-Yan-Ling Yi Xiao-Nan Zheng Yang Yang Yan Wang Da-Zhou Liao Jia-Peng Zhang Ping Tan Xing-Yu Xiong Xi Jin Li-Na Gong Shi Qiu De-Hong Cao Hong Li Qiang Wei Lu Yang Jian-Zhong Ai 
National Key R&D Plan(2023YFC3403200);National Natural Science Foundation of China(82070784,81702536,81974099 and 82170785);Science&Technology Department of Sichuan Province,China(2022JDRC0040,21GJHZ0246);Young Investigator Award of Sichuan University 2017(2017SCU04A17);Sichuan University-Panzhihua Science and Technology Cooperation Special Fund(2020CDPZH-4);China Postdoctoral Science Foundation(2021M692306);Post-Doctor Research Project of West China Hospital of Sichuan University(2021HXBH025).
Background Cell metabolism plays a pivotal role in tumor progression,and targeting cancer metabolism might effectively kill cancer cells.We aimed to investigate the role of hexokinases in prostate cancer(PCa)and ident...
关键词：Prostate cancer(PCa) ADP-dependent glucokinase(ADPGK) Aldolase C(ALDOC) AMPK Glycolysis 
A Family of GCK-MODY, About 02 Cases and Review of the Literature
《Open Journal of Endocrine and Metabolic Diseases》2024年第7期135-142,共8页Malad Mohamed Tadlaoui Abderrahman Riznat Malak Guerboub Ahmed Anas 
Positive diagnosis of diabetes is currently easy, but typing diagnosis of diabetes still remains a challenge for every clinician. It is currently accepted that types of diabetes apart from T1D and T2D can expand and i...
关键词：Maturity Onset Diabetes of the Young Diabetes Typing Glucokinase GCK Mutation 
Glucokinase regulatory protein rs780094 polymorphism is associated with type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease, and nephropathy
《World Journal of Diabetes》2024年第5期814-817,共4页Ashraf Al Madhoun 
Supported by the Kuwait Foundation for the Advancement of Sciences(KFAS)and Dasman Diabetes Institute,No.RACB-2021-007.
In this editorial,we comment on the article by Liu et al published in the recent issue of the World Journal of Diabetes(Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria).Type 2...
关键词：Glucokinase regulatory protein rs780094 Type 2 diabetes mellitus DYSLIPIDEMIA Non-alcoholic fatty liver disease NEPHROPATHY 
Management of monogenic diabetes in pregnancy:A narrative review
《World Journal of Diabetes》2024年第1期15-23,共9页Mohammad Sadiq Jeeyavudeen Sarah R Murray Mark W J Strachan 
Pregnancy in women with monogenic diabetes is potentially complex,with significant implications for both maternal and fetal health.Among these,maturity-onset diabetes of the young(MODY)stands out as a prevalent monoge...
关键词：Diabetes Pregnancy Maturity-onset diabetes of the young INSULIN SULPHONYLUREA GLUCOKINASE Hepatocyte nuclear factor 1-alpha hepatocyte nuclear factor 1-beta and hepatocyte nuclear factor 4-alpha 
Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria被引量：1
《World Journal of Diabetes》2023年第12期1803-1812,共10页Yi-Ying Liu Qin Wan 
the Key R&D Project of the Ministry of Science and Technology,No.2016YFC0901200 and 2016YFC0901205.
BACKGROUND Diabetic kidney disease is one of the common complications of type 2 diabetes(T2D).There are no typical symptoms in the early stage,and the disease will progress to moderate and late stage when albuminuria ...
关键词：Type 2 diabetes mellitus ALBUMINURIA Glucokinase regulatory protein rs780094 Gene polymorphism 
Glucokinase and glucokinase activator被引量：1
《Life Metabolism》2023年第5期12-16,共5页Changhong Li Yi Zhang Li Chen Xiaoying Li 
supported by the grant from the National Natural Science Foundation of China(No.32241011).
Glucokinase (GK) plays a pivotal role in glucose homeostasis as the glucose sensor in the pancreas and liver. Loss of function of GK results in hyperglycemia, and gain of function causes congenital hyperinsulinemic hy...
关键词：glucokinases glucokinase activator Type 2 diabetes pancreaticβcells LIVER glucose homeostasis 
Docking of Glycokinase with Oxo, Sulfo, and Seleno Derivatives of the Carboxamide Activator S41
《Crystal Structure Theory and Applications》2020年第2期22-35,共14页Glodi M. Ndefi Albert S. Lundemba Dikima D. Bibelayi Jason T. Kilembe Eliakim M. Kambale Céline W. Kadima Zéphyrin G. Yav 
Inactivation of Glucokinase (GK) is associated with diabetes. Therefore, design of drugs targeting the GK activator site is currently integrated in the?strategy of the diabetes treatment.?The present work investigated...
关键词：GLUCOKINASE CARBOXAMIDE DERIVATIVES GOLD 5.6 Binding Energy Molecular Electrostatic Potential (MEP) 
Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population被引量：4
《Journal of Clinical and Translational Hepatology》2019年第4期297-303,共7页Hui Gao Shousheng Liu Zhenzhen Zhao Xinjuan Yu Qun Liu Yongning Xin Shiying Xuan 
This study was supported by grants from the National Natural Science Foundation of China(31770837);the Qingdao People's Livelihood Science and Technology Plan(18-6-1-68-nsh)
Background and Aims: Accumulated studies have eval-uated the effects of glucokinase regulatory protein(GCKR)gene polymorphisms on the risk of nonalcoholic fatty liver disease(NAFLD)and coronary artery disease(CAD),but...
关键词：Non-alcoholic fatty liver disease Glucokinase regulatory protein gene POLYMORPHISM Coronary artery disease 
Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables被引量：3
《World Journal of Gastroenterology》2018年第43期4835-4845,共11页Umberto Vespasiani-Gentilucci Paolo Gallo Chiara Dell' Unto Mara Volpentesta Raffaele Antonelli-Incalzi Antonio Picardi 
Non-alcoholic fatty liver disease(NAFLD) has a prevalence of approximately 30% in western countries, and is emerging as the first cause of liver cirrhosis and hepatocellular carcinoma(HCC). Therefore, risk stratificat...
关键词：Non-alcoholic fatty liver disease Single nucleotide polymorphism Patatin-like phospholipase domain-containing protein 3 Transmembrane 6 superfamily member 2 Membrane bound O-acyltransferasedomain containing 7 Glucokinase regulatory gene Risk score Non-alcoholic steatohepatitis Non-alcoholic steatohepatitis cirrhosis Hepatocellular carcinoma 
Sapium ellipticum(Hochst) Pax ethanol leaf extract modulates glucokinase and glucose-6-phosphatase activities in streptozotocin induced diabetic rats被引量：1
《Asian Pacific Journal of Tropical Biomedicine》2017年第6期544-548,共5页Osasenaga Macdonald Ighodaro Oluseyi Adeboye Akinloye Regina Ngozi Ugbaja Samuel Olatunbosun Omotainse 
Objective:To examine the effects of Sapium ellipticum(SE) leaf extract on the hepatic activities of glucokinase and glucose-6-phosphatase in streptozotocin-induced diabetic Wistar rats.Methods:STZ-induced diabetic Wis...
关键词：Sapium ellipticum Glucose homeostasis DIABETES GLUCOKINASE GLUCOSE-6-PHOSPHATASE 
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