Background and aims:Human positive cofactor 4(PC4)is associated with the development and therapeutic resistance of several malignancies.However,the role of PC4 in hepatocellular carcinoma(HCC)remains obscure.Methods:T...
supported by grants from the National Natural Science Foundation of China (81874226 and 81803020);the “Three Million for Three Years” Project of the High-Level Talent Special Funding Scheme of Sun Yat-sen Memorial Hospital;the Guangdong Natural Science Foundation (2016A030313834and 2017A030313871,China)
Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma(HCC).Herein,RNAseq analysis revealed that elevated tubulin folding cofactor E(TBCE)expression is asso...
This work was supported by National Cancer Institute(NCI)R01 grants(CA197865,CA229869);University of Cincinnati Cancer Center and Ride Cincinnati Award(to X.Zhang).
Breast cancer is one of the most common cancer and leading causes of death in women in the United States and Worldwide.About 90%of breast cancers belong to ER+or HER2+subtypes and are driven by key breast cancer genes...
The LIM domain only 1(LMO1)gene belongs to the LMO family of genes that encodes a group of transcriptional cofactors.This group of transcriptional cofactors regulates gene transcription by acting as a key"connector"or...
This work was supported by the grants from National Key Research and Development Program of China(Grant number 2108YFA0107800);National Natural Science Foundation of China(Grant numbers 81920108004,81770107,81702722,81470362 and 81700168);National Postdoctoral Program for Innovative Talents(Grant number BX201700292);Natural Science Foundation of Hunan Province(Grant num ber 2018JJ3703);Science and Technology Key Project of Hunan Province(Grant number 2018SK21212);Fundamental Research Funds for the Central Universities of Central South University(Grant number 2018zzts386).
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development.The regulation of gene transcription involves not only individual transcription factors(TFs)but also transcription complex...
National Key Research and Development Program,grant/award number:2016YFC1000805;University Innovation Team Building Program of Chongqing,grant/award number:CXTDG201602020;Intramural research project grants:AWS17J007,2018-JCJQ-ZQ-001.
Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role ...
Introduction: High grade dysplasia of the cervix has a high incidence and can progress to cervical cancer. The aim was to study cofactors associated with high-grade cervical dysplasia. Methodology: This was a retrospe...
BACKGROUND The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showe...
supported by the National Natural Science Foundation of China(No.81574025);the Open Project Program of Jiangsu Key Laboratory of Pediatric Respiratory Disease,Nanjing University of Chinese Medicine(No.JKLPRD201410)
Respiratory syncytial virus(RSV) is a leading cause of acute lower respiratory tract infections. Qingfei oral liquid(QFOL), a traditional Chinese medicine, is widely used in clinical treatment for RSV-induced pneumoni...
supported by the National Natural Science Foundation of China(No.91129706);NSFCShandong Joint Fund(No.U1406402);Taishan Scholar Special Fund of Shandong Province in China(L.Z.)
Cardiovascular disease is the leading causes of death.However,the complications can be treated with heparin and heparinoids,such as heparin pentasaccharide Fondaparinux,dermatan sulfate,and PSS made from alginate extr...