COFACTOR

作品数：50被引量：72H指数：4
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相关领域：生物学医药卫生更多>>
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相关机构：北京奶牛中心新疆维吾尔自治区畜牧总站中国农业大学新疆农业大学更多>>
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  • 学科=医药卫生—临床医学x
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Identification of positive cofactor 4 as a diagnostic and prognostic biomarker associated with immune infiltration in hepatocellular carcinoma
《iLIVER》2023年第4期188-201,共14页Liangliang Bai Guan Liu Gang Dou Xiaojun He Chenyu Gong Hongbin Zhang Kai Tan Xilin Du 
Background and aims:Human positive cofactor 4(PC4)is associated with the development and therapeutic resistance of several malignancies.However,the role of PC4 in hepatocellular carcinoma(HCC)remains obscure.Methods:T...
关键词：Hepatocellular carcinomaHuman positive cofactor 4 Prognosis Risk signature 
Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer被引量：1
《Acta Pharmaceutica Sinica B》2023年第3期967-981,共15页Senlin Li Siyu Chen Zhihui Dong Xingdong Song Xiuling Li Ziqi Huang Huiru Li Linzhuo Huang Ganyuan Zhuang Ran Lan Mingyan Guo Wende Li Phei Er Saw Lei Zhang 
supported by grants from the National Natural Science Foundation of China (81874226 and 81803020);the “Three Million for Three Years” Project of the High-Level Talent Special Funding Scheme of Sun Yat-sen Memorial Hospital;the Guangdong Natural Science Foundation (2016A030313834and 2017A030313871,China)
Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma(HCC).Herein,RNAseq analysis revealed that elevated tubulin folding cofactor E(TBCE)expression is asso...
关键词：Hepatocellular carcinoma Tubulin folding cofactor E CHEMORESISTANCE siRNA delivery RNA interference Nanoparticle Combination therapy NANOMEDICINE 
Transcriptional coactivator MED1 in the interface of anti-estrogen and anti-HER2 therapeutic resistance被引量：2
《Cancer Drug Resistance》2022年第2期498-510,共13页Gregory Bick Jasmine Zhang Elyse E.Lower Xiaoting Zhang 
This work was supported by National Cancer Institute(NCI)R01 grants(CA197865,CA229869);University of Cincinnati Cancer Center and Ride Cincinnati Award(to X.Zhang).
Breast cancer is one of the most common cancer and leading causes of death in women in the United States and Worldwide.About 90%of breast cancers belong to ER+or HER2+subtypes and are driven by key breast cancer genes...
关键词：MED1 transcription cofactor estrogen receptor HER2 therapy resistance RNA nanotechnology 
LIM domain only 1:an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types
《Chinese Medical Journal》2021年第9期1017-1030,共14页Guo-Fa Zhao Li-Qin Du Lei Zhang You-Chao Jia 
The LIM domain only 1(LMO1)gene belongs to the LMO family of genes that encodes a group of transcriptional cofactors.This group of transcriptional cofactors regulates gene transcription by acting as a key"connector"or...
关键词：LIM domain only 1 Cancer Single-nucleotide polymorphisms T-cell acute lymphoblastic leukemia NEUROBLASTOMA 
Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies被引量：3
《Signal Transduction and Targeted Therapy》2021年第2期409-424,共16页Zi Wang Pan Wang Yanan Li Hongling Peng Yu Zhu Narla Mohandas Jing Liu 
This work was supported by the grants from National Key Research and Development Program of China(Grant number 2108YFA0107800);National Natural Science Foundation of China(Grant numbers 81920108004,81770107,81702722,81470362 and 81700168);National Postdoctoral Program for Innovative Talents(Grant number BX201700292);Natural Science Foundation of Hunan Province(Grant num ber 2018JJ3703);Science and Technology Key Project of Hunan Province(Grant number 2018SK21212);Fundamental Research Funds for the Central Universities of Central South University(Grant number 2018zzts386).
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development.The regulation of gene transcription involves not only individual transcription factors(TFs)but also transcription complex...
关键词：HEMATOPOIESIS COFACTOR LANDSCAPE 
PC4 serves as a negative regulator of skin wound healing in mice被引量：1
《Burns & Trauma》2020年第1期310-318,共9页Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi 
National Key Research and Development Program,grant/award number:2016YFC1000805;University Innovation Team Building Program of Chongqing,grant/award number:CXTDG201602020;Intramural research project grants:AWS17J007,2018-JCJQ-ZQ-001.
Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role ...
关键词：Wound healing SKIN PC4 PROLIFERATION MIGRATION Positive cofactor 4 
Study of Cofactors Associated with Precancerous High-Grade Cervical Lesions at the Teaching Hospital Gabriel Touré, 2010 to 2015
《Surgical Science》2019年第9期328-337,共10页Fané Seydou Bocoum Amadou Sissoko Abdoulaye Traoré Soumana Oumar Sanogo Siaka Amara Mamadou Sima Kouma Aminata Traoré Alassane Tegueté Ibrahima Traoré Youssouf Mounkoro Niani 
Introduction: High grade dysplasia of the cervix has a high incidence and can progress to cervical cancer. The aim was to study cofactors associated with high-grade cervical dysplasia. Methodology: This was a retrospe...
关键词：High Grade Dysplasia COFACTOR Cervical Cancer Teaching Hospital GABRIEL Touré 
Factors Affecting Fines Flocculation Performance with Cofactor-Polyethylene Oxide
《Advances in Chemical Engineering and Science》2014年第1期49-55,共7页M. R. Abdallah Qasaimeh Ahmad Qasaimeh F. Bani Hani 
In literature, neutral polyethylene oxide (PEO) flocculated fines at low shear rates, while with cofactor (CF) addition, the formed CF-PEO complex showed larger ability to bridge fines, producing flocs. In this work, ...
关键词：POLYETHYLENE Oxide COFACTOR FLOCCULATION SHEARING and BRIDGING 
Effective cofactor complex purification using nanobeads
《Journal of Biosciences and Medicines》2013年第3期5-10,共6页Makoto Umeda Tatsuya Uebi Naoya Maekawa Yuka Masaike Hiroshi Handa Takeshi Imai 
Drug target factor complex identification is necessary for evidence based drug discovery. Previous study showed that using small chemical immobilized magnetic nanobeads the chemical target factors were effectively pur...
关键词：ARGININE Nanobeads 
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