BACKGROUND Coronary heart disease is associated with coronary atherosclerosis indicated by carotid intima-media thickness(CIMT)thickening and altered vascular elasticity.The epicardial adipose layer can secrete proinf...
In recent years,the field of mechanomaterials has emerged at the interface of mechanics,materials science,biology,medicine and data science,where materials are proactively designed or programmed to achieve targeted fu...
supported by the grants from the Key Project of Technology Innovation and Application Development in Chongqing(No.CSTB2023TIAD-KPX0048);the Construction of Graduate Tutor Team in Chongqing Medical University(No.cqmudstd202205);the National Natural Science Foundation of China Youth Science Fund Project(No.81800254);the Postdoctoral Project of Chongqing Natural Science Foundation(No.CSTB2022NSCQ-BHX0626).
The epicardium is integral to cardiac development and facilitates endogenous heart regeneration and repair.While miR-194-3p is associated with cellular migration and invasion,its impact on epicardial cells remains unc...
supported by grants from the National Natural Science Foundation of China(Grant No.:82270281);Chongqing Medical University Program for Youth Innovation in Future Medicine(Grant No.:W0133);Senior Medical Talents Program of Chongqing for Young and Middle-aged,China(Program No.:JianlinDu[2022]);Postdoctoral Research Funding of the Second Affiliated Hospital of Chongqing Medical University,China(Grant No.:rsc-postdoctor114);and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University,China(Program No.:kryc-gg-2102).
Tbx18,Wt1,and Tcf21 have been identified as epicardial markers during the early embryonic stage.However,the gene markers of mature epicardial cells remain unclear.Single-cell transcriptomic analysis was performed with...
support:R01EB022018,R15HL140503,T32 HL134613 from NIH,UT STARS.
Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac biomechanics.Previous studies have mainly focused on collagen,the major structural ECM in heart wall.The role of elastin in cardiac mechanics...
To the Editor: Left atrial appendage (LAA) is one of the major sources of atrial arrhythmias in children.[1] But atrial tachycardia (AT) with an epicardial LAA origin is uncommon and usually arises from the base.[2] C...
The research in the Han’s lab is supported by the National Natural Science Foundation of China(31871462);the National Key R&D Program of China(2018YFA0800501,2018YFC1004801)。
Heart disease is the leading cause of mortality worldwide.Due to the limited proliferation rate of mature cardiomyocytes,adult mammalian hearts are unable to regenerate damaged cardiac muscle following injury.Instead,...
Background:Most children in need of cardiac pacemakers remain dependent on the function of the permanent from childhood to adulthood.We sought to evaluate and compare the function between epicardial and endocardial pa...
Natural Science Basic Research Program of Shaanxi Province,No.2020JQ-939;and Science and Technology Development Incubation Fund Project of Shaanxi Provincial People’s Hospital,No.2019YXQ-08.
BACKGROUND Arrhythmogenic right ventricular(RV)cardiomyopathy is a rare and currently underrecognized cardiomyopathy characterized by the replacement of RV myocardium by fibrofatty tissue.It may be asymptomatic or sym...