云南高校图书馆联盟文献共享服务平台- CONOTOXIN

CONOTOXIN: 作品数：26被引量：51H指数：5; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：周晓薇戴秋云刘凤云黄培堂李晓玲更多>>; 相关机构：犹他大学研究基金会军事医学科学院药理学教研室更多>>; 相关期刊：《Progress in Natural Science:Materials International》《Asian Pacific Journal of Tropical Biomedicine》《Asian Pacific Journal of Tropical Medicine》《Tsinghua Science and Technology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划面向21世纪教育振兴行动计划中国博士后科学基金更多>>

Identification and Expression of the Conotoxin Homologous Genes in the Giant Triton Snail (Charonia tritonis): 《Journal of Ocean University of China》2023年第1期213-220,共8页JIA Huixia ZHANG Gege ZHANG Chenglong ZHANG Hua YAO Gaoyou HE Maoxian LIU Wenguang; supported by the National Natural Science Foundation of China(No.42176129);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA13020206);the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0402);the Planning Project of Guangdong Province,China,Guangdong Provincial Key Laboratory of Applied Marine Biology(No.2020B1212060058).; Conotoxin(CTX)is a small peptide toxin,and plays crucial role in anesthetizes prey,preys and defends competitors.Charonia tritonis is the natural predator of the crown of thorns starfish(CoTS)and the protector of cora...; 关键词：Charonia tritonis TOXIN tissue distribution predation experiment

Mechanism of interactions betweenα-conotoxin RegIIA and carbohydrates at the humanα3β4 nicotinic acetylcholine receptor: 《Marine Life Science & Technology》2022年第1期98-105,共8页Meiling Zheng Han-Shen Tae Liang Xue Tao Jiang Rilei Yu; supported by the National Key Research and Development Program(2019YFC0312601);the grant from the Fundamental Research Funds for the Central Universities(201762011 and 201941012);National Natural Science Foundation of China(NSFC)(No.81502977 and 41830535);an Australian Research Council(ARC)Discovery Project Grant(DP150103990 awarded to Prof D.J.Adams)。; Conotoxins are marine peptide toxins from marine cone snails.Theα-conotoxin RegIIA can selectively act on human(h)α3β4 nicotinic acetylcholine receptor(nAChR),and is an important lead for drug development.The high-...; 关键词：Oligosaccharide chains NACHR CONOTOXIN Action mechanism

A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity被引量：4: 《Acta Pharmaceutica Sinica B》2021年第9期2685-2693,共9页Jinqin Chen Xinhong Liu Shuo Yu Jia Liu Rongfang Chen Yunxiao Zhang Ling Jiang Qiuyun Dai; supported by the National Natural Science Foundation of China(grant number 81473192);the National Basic Research Program of China(grant number 2010CB529802); ω-Conotoxins inhibit N-type voltage-gated calcium(Ca_(v)2.2)channels and exhibit efficacy in attenuating neuropathic pain but have a low therapeutic index.Here,we synthesized and characterized a novelω-conotoxin,Bu8...; 关键词：N-type calcium ion channel ω-conotoxin Bu8 Analgesic activity Structure-activity relationship

Isolation and characterization of five novel mini-M conotoxins from the venom of mollusk-hunter snail Conus bandanus: 《Asian Pacific Journal of Tropical Biomedicine》2020年第8期343-352,共10页Nguyen Bao Jean-Pière LE CAER Phan Thi Khanh Vinh; funded by Vietnam National Foundation for Science and Technology Development(NAFOSTED)under grant number 106-NN.02-2015.14; Objective:To determine the new M-superfamily conotoxins from molluscivorous snail Conus bandanus in Vietnam.Methods:Conus bandanus venom was fractionated and purified on HPLC system with an analytical reversed-phase C...; 关键词：Mini-M conotoxin Conus bandanus Cone snail venom

Characterization of α-conotoxin TxIB and TxID for smoking cessation and drug rehabilitation: 《中国药理学与毒理学杂志》2018年第9期711-713,共3页ZHANGSUN Dong-ting ZHU Xiao-peng ZHANGSUN Man-qi WU Yong LI Xiao-dan Sean CHRISTENSEN Quentin KAAS Peta J HARVEY David J CRAIK J Michael MCINTOSH LUO Su-lan; Nicotinic acetylcholine receptors(nAChRs) are widely distributed ligand gated ion channels throughout the peripheral and central nervous systems of mammals.There are 16 different n AChR subunits,α1-α7,α9,α10 and ...; 关键词：ACETYLCHOLINE RECEPTORS smokingcessation DRUG REHABILITATION α-conotoxins

The crystal structure of Ac-AChBP in complex with α-conotoxin LvlA reveals the mechanism of its selectivity towards different nAChR subtypes被引量：3: 《Protein & Cell》2017年第9期675-685,共11页Manyu Xu Xiaopeng Zhu Jinfang Yu Jinpeng Yu Sulan Luo Xinquan Wang; ACKNOWLEDGEMENTS We thank scientists at SSRF BL17U beam line for assistance in diffraction data collection. This work was supported by the National Natural Science Foundation of China （Grant Nos. 31470751 and U1405228 to Xinquan Wang） and the Beijing Advanced Innovation Center for Structural Biology. This work was also supported, in part, by the Major Intemational Joint Research Project of National Natural Science Foundation of China （81420108028）, and Changjiang Scholars and Innovative Research Teams in Universities Grant （IRT_I 5R15）.; The a3＊ nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous syste...; 关键词：base editor high-fidelity mouse embryos proximal-site deamination whole-genome sequencing

Preparation of Conotoxin MrVIB by Genetic Engineering Technology: 《Agricultural Biotechnology》2017年第4期28-31,37,共5页Weiwei GUAN Jie HOU Xia ZHONG Na WEI Junqing ZHANG Bingmiao GAO; Supported by Natural Science Foundation of China(81560611);Natural Science Foundation of Hainan Province(No.317170); [ Objective] The disulfide-rich conotoxin MrV1B was produced by simple and fast genetic engineering method, to find new efficient ways for the synthesis of natural active conotoxins. [Method] Primers of conotoxin gene...; 关键词：CONOTOXINS Escherichia coli Genetic Engineering Recombinant Expression Separation and Purification

Computational Determination of the Binding Mode of α-Conotoxin to Nicotinic Acetylcholine Receptor: 《Journal of Ocean University of China》2016年第6期1027-1033,共7页TABASSUM Nargis YU Rilei JIANG Tao; supported by the National Natural Science Foundation of China (81502977 to Dr. Yu R. and 81373322 to Dr. Jiang T.);China Postdoctoral Science Foundation funded project (No.861505020050 for Dr. Yu R.);Special Foundation for Qingdao Basic Research Program (15-9-1-85-jch);Fundamental Research Funds for the Central Universities (No.841512007 for Dr. Yu R.); Abstract Conotoxins belong to the large families of disulfide-rich peptide toxins from cone snail venom, and can act on a broad spectrum of ion channels and receptors. They are classified into different subtypes based...; 关键词：Nicotinic acetylcholine receptor a-conotoxin acetylcholine binding protein DOCKING homology modeling moleculardynamics simulation mutational energy

A novel 4/6-type alpha-conotoxin VilA selectively inhibits nAchR α3β2 subtype被引量：4: 《Acta Biochimica et Biophysica Sinica》2015年第12期1023-1028,共6页Liang Li Na Liu Rong Ding Shuo Wang Zhuguo Liu Haiying Li Xing Zheng Oiuyun Dai; Conotoxins （CTxs） are typically small peptides composed of 12-50 amino acid residues with 2-5 disulfide bridges. Most of them potently and selectively target a wide variety of ion channels and membrane receptors. Th...; 关键词：α-conotoxin VilA CLONING synthesis α3β2 nAChR subtype

A perspective on toxicology of Conus venom peptides: 《Asian Pacific Journal of Tropical Medicine》2015年第5期337-351,共15页Palanisamy Satheesh Kumar Dhanabalan Senthil Kumar Sundaresan Umamaheswari; The evolutionarily unique and ecologically diverse family Conidae presents fundamental opportunities for marine pharmacology research and drug discovery.The focus of this investigation is to summarize the worldwide di...; 关键词：Distribution CONUS CONOTOXIN Peptide TOXICOLOGY PHARMACOLOGY

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