MALEATE

作品数：39被引量：53H指数：4
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相关作者：张存根周锦鑫马紫峰赵冬梅张凤美更多>>
相关机构：沈阳药科大学上海交通大学安徽师范大学华北制药集团新药研究开发有限责任公司更多>>
相关期刊：《Journal of Biomaterials and Nanobiotechnology》《Journal of Rare Earths》《Journal of Wuhan University of Technology(Materials Science)》《Green Energy & Environment》更多>>
相关基金：国家自然科学基金上海市自然科学基金安徽省教委科研基金福建省自然科学基金更多>>
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Some Maleate New Tin (IV) and Magnesium or Zinc Chloride Adduct and Derivative: Synthesis and Spectroscopic Study
《Journal of Environmental Science and Engineering(B)》2024年第6期262-266,共5页Boucar Diouf Waly Diallo Daouda Ndoye Bocar Traoré Mamadou Sidibé 
Three new maleate compounds have been synthesized and studied by infrared,25Mg NMR(Nuclear Magnetic Resonance)Spectroscopy and UV(Ultraviolet)-visible spectroscopies.The suggested structures for the three complexes ar...
关键词：Discrete structures hydrogen bonds monochelating bichetating octahedral or tetrahedral environments MALEATE supramolecular. 
Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases:therapeutic effects and molecular mechanisms被引量：5
《Acta Pharmacologica Sinica》2022年第12期3055-3061,共7页Xiao Tong Li Chen Shi-jun He Jian-ping Zuo 
This work was supported by the National Natural Science Foundation of China(Grant Number:81871240);Science and Technology Commission of Shanghai Municipality Natural Science Foundation of Shanghai(Grant Number:22ZR1473700);Science and Technology Commission of Shanghai Municipality(Grant numbers:21S11911000,21S11907700).
Artemisinin and its derivatives are the well-known anti-malarial drugs derived from a traditional Chinese medicine.In addition to antimalarial,artemisinin and its derivatives possess distinguished anti-cancer,anti-oxi...
关键词：artemisinin derivative β-aminoarteether maleate(SM934) autoimmune and inflammatory diseases T helper cells MACROPHAGES inflammatory cytokines 
One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C
《World Journal of Clinical Cases》2022年第28期10085-10096,共12页Jing-Hang Xu Sa Wang Da-Zhi Zhang Yan-Yan Yu Chong-Wen Si Zheng Zeng Zhong-Nan Xu Jun Li Qing Mao Hong Tang Ji-Fang Sheng Xin-Yue Chen Qin Ning Guang-Feng Shi Qing Xie Xi-Quan Zhang Jun Dai 
BACKGROUND Entecavir(ETV)is a potent and selective nucleotide analog with significant activity against hepatitis B virus(HBV).ETV maleate is a derivative compound of ETV and was reported to have an efficacy and safety...
关键词：Chronic hepatitis B Entecavir maleate Randomized controlled trial Treatment outcome MUTATION GENOTYPE 
The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling被引量：17
《Acta Pharmacologica Sinica》2021年第4期593-603,共11页Fang-ming Yang Di Fan Xiao-qian Yang Feng-hua Zhu Mei-juan Shao Qian Li Yu-ting Liu Ze-min Lin Shi-qi Cao Wei Tang Shi-jun He Jian-ping Zuo 
supported by the National Natural Science Foundation of China(NSFC)(Grant No.81871240);the National Science and Technology Major Project“New Drug Creation and Manufacturing Program,”China(Grant No.2018ZX09711002-014-001);the Personalized Medicines—Molecular Signature-based“Drug Discovery and Development,”Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA12020107 and XDA12020369).
Dry eye disease(DED)is a multifactorial disorder of the tears and ocular surface characterized by manifestations of dryness and irritation.Although the pathogenesis is not fully illuminated,it is recognized that infla...
关键词：dry eye disease artemisinin derivative β-aminoarteether maleate inflammation MACROPHAGES TLR4 INFLAMMASOME 
Selective production of diethyl maleate from lignin
《Green Energy & Environment》2019年第4期343-344,共2页Buxing Han 
Lignin is an abundant and renewable carbon resource and also a by-product in the paper industry.Transformation of lignin into valuable chemicals and liquid fuels has attracted extensive interest.Selective lignin depol...
关键词：LIGNIN OXIDATIVE utilized 
治疗血小板减少症新药——马来酸阿凡泊帕(avatrombopag maleate)被引量：3
《医药导报》2019年第1期130-134,共5页陈本川 
马来酸阿凡泊帕(avatrombopag maleate)是血小板生成素受体激动药,最早由日本安斯泰来制药集团研制,几经授权,最后由美国Dova制药公司的子公司AkaRx制药公司完成新药研制,向美国食品药品管理局(FDA)提出新药上市申请,于2018年5月21日获...
关键词：阿凡泊帕 马来酸 血小板减少症 血小板生成素受体激动药 肝病 慢性 Avatrombopag maleate Doptelet 
Avatrombopag maleate(Doptelet)
《中国药物化学杂志》2018年第6期516-516,共1页武彩娇(编译) 陈国良(审校) 
2018年5月21日,Dova制药子公司AkaRx公司研发的avatrombopag maleate片剂经美国FDA批准上市(商品名为Doptelet),用于治疗成人慢性肝病(CLD)导致的血小板减少症,这是FDA批准用于此用途的第一款药物[1]。血小板减少症(thrombocytopenia)...
关键词：血小板 Doptelet MALEATE FDA 减少 
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors被引量：4
《Acta Pharmacologica Sinica》2018年第2期302-310,共9页Mao-rong ZHU Dao-hai DU Jun-chi HU Lian-chun LI Jing-qiu LIU Hong DING Xiang-qian KONG Hua-liang JIANG Kai-xian CHEN Cheng LUO 
The authors disclose the following financial support for this research and/or authorship of this article： the Ministry of Sci- ence and Technology of China （2015CB910304 to Hua-liang JIANG）, the National Natural Science Foundation of China （21472208 and 81625022 to Cheng LUO, 21210003, 81230076 and 91313000 to Hua-liang JIANG）, and the Fund of the State Key Laboratory of Toxicology and Medical Countermeasures, Academy of Military Medical Science （TMC201505 to Cheng LUO）. We are extremely grateful to the National Centre for Protein Science Shanghai （Shanghai Science Research Center, Protein Expression and Purification System） for providing instrument support and technical assistance.
Aberrant activity of enhancer of zeste homolog 2 （EZH2） is associated with a wide range of human cancers. The interaction of EZH2 with embryonic ectoderm development （EED） is required for EZH2＇s catalytic activit...
关键词：PRC2 EZH2 EED protein-protein interaction fluorescencepolarization high-throughput screening apomorphine hydrochloride oxyphenbutazone NIFEDIPINE ergonovine maleate 
马来酸来那替尼的合成工艺研究
《化工管理》2017年第11期46-46,共1页李亚楠 王芹芳 刘魏 彭冲 赵晶晶 
马来酸来那替尼(Neratinib Maleate)是一种新型的不可逆的Erb B受体酪氨酸激酶抑制剂(ErbB-TKI),能有效抑制ErbB-1酪氨酸激酶和ErbB-2酪氨酸激酶活性。本文就其合成方法进行综述,以咨为医药开发提供参考借鉴。
关键词：马来酸来那替尼 合成 Neratinib MALEATE 
Preparation of Triethylene Glycol Maleate and Its Effect on Plasticization of Oxidized Starch被引量：1
《Journal of Wuhan University of Technology(Materials Science)》2016年第5期1167-1173,共7页程飞 LIN Yi ZHAO Kang 朱谱新 
Funded by Science and Technology Support Project of Sichuan Province(Nos.2014GZ0136 and 2015GZ0176);National Natural Science Foundation of China(No.51603134)
A plasticizer triethylene glycol maleate（TEG-MA） was synthesized. The dominated monoester of moderate hydrophobicity with apparent oil-water partition coefficient of 0.042 in the product was confirmed by acid value ...
关键词：starch plasticization triethylene glycol maleic anhydride hygroscopicity 
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