POLYPLEX

作品数:16被引量:9H指数:2
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相关领域:医药卫生化学工程更多>>
相关作者:陈顺冯佳张士荣白光吴飞更多>>
相关机构:上海交通大学沈阳药科大学更多>>
相关期刊:《Chinese Journal of Polymer Science》《聚酯工业》《Neural Regeneration Research》《Asian Journal of Pharmaceutical Sciences》更多>>
相关基金:国家自然科学基金中国博士后科学基金国家教育部博士点基金更多>>
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Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy被引量:2
《Nano Research》2018年第7期3746-3761,共16页Gang Chen Kaikai Wang Pengkai Wu Yixin Wang Zhanwei Zhou Lifang Yin Minjie Sun David Oupicky 
This work was financially supported by the National Science and Technology Major Project (No. 2017YFA0205400), the Changjiang Scholar program, the National Natural Science Foundation of China (Nos. 81373983 and 81573377), China Postdoctoral Science Foundation (No. 2016M601923), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (No. KYCX17_0671).
We report the development of a small interfering RNA (siRNA) delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodecalin (PFD) emulsions with a positive surface charge provid...
关键词:POLYPLEXES fluorous interactions small interfering RNA(siRNA) delivery tumor deliver perfluorocarbon emulsion 
核酸载体lipopolyplex的制备及细胞毒性研究
《现代生物医学进展》2015年第27期5204-5207,共4页张士荣 冯佳 陈顺 白光 车俊怡 吴飞 
国家自然科学基金项目(81373352)
目的:为降低聚阳离子基因载体polyplex的正电荷和毒性,在其表面构建中性磷脂膜制备lipopolyplex,并测定lipopolyplex对小鼠结肠癌细胞CT26和人乳腺癌细胞MCF-7的细胞毒性。方法:采用PEI25KDa与DNA复合制备polyplex,在polyplex体系中加...
关键词:POLYPLEX 中性磷脂 Lipopolyplex ZETA电位 细胞毒性 
Novel cyclen-based linear polymer as a high-affinity binding material for DNA condensation被引量:3
《Science China Chemistry》2009年第4期483-488,共6页XIANG YongZhe WANG Na ZHANG Ji LI Kun ZHANG ZhongWei LIN HongHui YU XiaoQi 
Supported by the National Natural Science Foundation of China (Grant Nos. 20725206 and 20732004);Specialized Research Fund for the Doctoral Program of Higher Education;Scientific Fund of Sichuan Province for Outstanding Young Scientist
A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity bindi...
关键词:CYCLEN (1 4 7 10-tetraazacyclododecane) POLYAMINE POLYPLEX DNA CONDENSATION 
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