POLYPLEXES

作品数：5被引量：12H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：梁文权陈海靓更多>>
相关机构：浙江大学更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《中国药学杂志》《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金中国博士后科学基金天津市自然科学基金更多>>
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Riboflavin-modified lipo-polyplexes co-delivering CXCR4 siRNA and doxorubicin for treatment of highly metastatic cancer被引量：2
《Journal of Chinese Pharmaceutical Sciences》2021年第3期189-205,共17页Kaisen Li Rudong Wang Yiwei Peng Dawen Dong Xianrong Qi 
The National Nature Science Foundation of China(Grant No.81973258 and 81673365);State Key Laboratory of Advanced Pharmaceutical Formulation with High Technology in Yangtze River Pharmaceutical Group.
SDF-1/CXCR4 has been recognized as one of the most relevant chemokine signaling pathways to cancer metastasis,and siRNA targeting CXCR4 may provide potential improvements to treat those highly metastatic cancers,espec...
关键词：RIBOFLAVIN Lipo-polyplexes CO-DELIVERY SIRNA DOXORUBICIN 
Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy被引量：2
《Nano Research》2018年第7期3746-3761,共16页Gang Chen Kaikai Wang Pengkai Wu Yixin Wang Zhanwei Zhou Lifang Yin Minjie Sun David Oupicky 
This work was financially supported by the National Science and Technology Major Project （No. 2017YFA0205400）, the Changjiang Scholar program, the National Natural Science Foundation of China （Nos. 81373983 and 81573377）, China Postdoctoral Science Foundation （No. 2016M601923）, and Postgraduate Research ＆ Practice Innovation Program of Jiangsu Province （No. KYCX17_0671）.
We report the development of a small interfering RNA （siRNA） delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodecalin （PFD） emulsions with a positive surface charge provid...
关键词：POLYPLEXES fluorous interactions small interfering RNA（siRNA） delivery tumor deliver perfluorocarbon emulsion 
A kind of modified bovine serum albumin with great potential for applying in gene delivery
《Chinese Chemical Letters》2013年第7期659-662,共4页Ning Zhang Chong-Xi Wang Jin-Hao Liu Jin-Feng Xing An-Jie Dong 
the financial support from National Natural Science Foundation of China(No.31100722);Tianjin Natural Science Foundation(No.13JCYBJC16500)
Bovine serum albumin （BSA） was modified through a facile synthesis method to increase its isoelectric point （pl） from 4.8 to 6.0. When pH is higher than 6.0, the protein shows a negative surface charge, on the con...
关键词：Bovine serum albumin Gene delivery Charge reversal Polyplexes 
Hepatocyte gene transfer mediated by stable polyplexes based on MPP-containing DNA complexes
《Hepatobiliary & Pancreatic Diseases International》2009年第5期498-503,共6页Yu, Bao-Feng Li, Wan-I Hu, Xiao-Nian Zhang, Yue-Hong Niu, Bo Xie, Jun 
supported by grants from the National Science&Technology Pillar Program(No.2007BA107A02)
BACKGROUND: In the field of gene therapy, viral vectors as delivery tools have a number of disadvantages for medical application. This study aimed to explore a novel nonviral vector as a vehicle for gene therapy. METH...
关键词：membrane penetrating peptide protein transduction gene therapy HEPATOCYTE 
阳离子聚合物在基因给药中的应用被引量：8
《中国药学杂志》2004年第1期11-13,共3页陈海靓 梁文权 
国家自然科学基金 (No .3 9970 879)
目的　介绍阳离子聚合物在基因给药系统中的应用研究进展。方法　总结近年文献 ,从阳离子聚合物的结构和种类、与DNA形成复合物的理化性质、介导基因转染的特点及入胞机制等方面进行分析和综述。结果　阳离子聚合物的结构具有较大的可变...
关键词：阳离子聚合物 基因给药 基因转染 POLYPLEXES 溶酶体酶 
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