ALDOLASE

作品数：29被引量：53H指数：4
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ADP‑dependent glucokinase:the ancient,archaeal key to prostate cancer
《Military Medical Research》2025年第3期467-468,共2页Marcin M.Kamiński 
The December 2023 issue of the Military Medical Research brings out an astounding discover y by Xu et al.[1]demonstrating a key role of the mysterious enzyme ADPdependent glucokinase(ADPGK)in the cellular metabolism o...
关键词：ADP-dependent glucokinase(ADPGK) Prostate cancer Prognostic marker ADENOCARCINOMA AMPactivated protein kinase(AMPK) Aldolase C(ALDOC) 
ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
《Military Medical Research》2024年第5期643-662,共20页Hang Xu Yi-Fan Li Xian-Yan-Ling Yi Xiao-Nan Zheng Yang Yang Yan Wang Da-Zhou Liao Jia-Peng Zhang Ping Tan Xing-Yu Xiong Xi Jin Li-Na Gong Shi Qiu De-Hong Cao Hong Li Qiang Wei Lu Yang Jian-Zhong Ai 
National Key R&D Plan(2023YFC3403200);National Natural Science Foundation of China(82070784,81702536,81974099 and 82170785);Science&Technology Department of Sichuan Province,China(2022JDRC0040,21GJHZ0246);Young Investigator Award of Sichuan University 2017(2017SCU04A17);Sichuan University-Panzhihua Science and Technology Cooperation Special Fund(2020CDPZH-4);China Postdoctoral Science Foundation(2021M692306);Post-Doctor Research Project of West China Hospital of Sichuan University(2021HXBH025).
Background Cell metabolism plays a pivotal role in tumor progression,and targeting cancer metabolism might effectively kill cancer cells.We aimed to investigate the role of hexokinases in prostate cancer(PCa)and ident...
关键词：Prostate cancer(PCa) ADP-dependent glucokinase(ADPGK) Aldolase C(ALDOC) AMPK Glycolysis 
Caspase-1 Cleavage of Aldolase B Impairs Hepatic Fructose Metabolism and Aggravates Chronic Viral Hepatitis
《Infectious Microbes & Diseases》2024年第2期74-84,共11页Hong Tang Haiming Hu Yanhang Gao Zhilong Wang Feng Yuan Chao Zhang Sisi Deng Pingyun Lyu Jingying Zhan Chengkai Li Hairong Chen Junqi Niu 
the National Natural Science Foundation of China(81530067,31621061,31300716);the Ministry of Science and Technology(2015CB554304);the Hubei Provincial Natural Science Foundation(2013CFB487);Shandong Laboratory Microecological Biomedicine(JNL-2023002B);the Fundamental Research Funds for the Central Universities(2022ZFJH003).
Of dietary monosaccharides,fructose is primarily metabolized by aldolase B(ALDOB)in the liver,whereas glucose is metabolized elsewhere in the body.It has been documented that overconsumption of dietary fructose,especi...
关键词：ALDOB fructose metabolism CASPASE-1 HCV 
Biotransformation of 2-keto-4-hydroxybutyrate via aldol condensation using an efficient and thermostable carboligase from Deinococcus radiodurans
《Bioresources and Bioprocessing》2024年第1期111-123,共13页Yeon-Ju Jeong Min-Ju Seo Bong Hyun Sung Jeong-Sun Kim Soo-Jin Yeom 
supported by Grants from the C1 Gas Refinery Program,funded by the Ministry of Science and ICT(NRF-2018M3D3A1A01056181);the Enzyme engineering for next generation biorefinery(NRF-2022M3J5A1056169 and NRF-2022M3J5A1085239)from National Research Foundation(NRF);the Korea Research Institute of Bioscience and the Biotechnology(KRIBB)Research Initiative Program.
The bioconversion of 4-hydroxy-2-keto acid derivatives via aldol condensation of formaldehyde and pyruvate has received substantial attention as potential source of chemicals for production of amino acids,hydroxy carb...
关键词：Formaldehyde PYRUVATE Pyruvate aldolase 2-keto-4-hydroxybutyrate Deinococcus radiodurans 
Studies on the co-metabolism of glucose and glycerol in the fungus Umbelopsis isabellina被引量：4
《Carbon Resources Conversion》2023年第4期326-333,共8页Panagiotis Dritsas George Aggelis 
financed by the Green Fund of the Hellenic Ministry of Environment and Energy,under the funding program“National Environment and Innovation Activities 2022”,Priority Axis“Research&Application”,Project“Sustainable technology for converting pomegranate residues into bioproducts and bioactive compounds”with the acronym“POMEGRANATE”.
Over the past few years,it is observed an increased interest for oleaginous microorganisms in the perspective to produce microbial oils of great commercial interest through the consumption of low/zero cost substrates....
关键词：Oleaginous microorganisms Umbelopsis isabellina Glucose and glycerol co-assimilation ALDOLASE Glycerol kinase Glycerol dehydrogenase 
Improvement of the activity and thermostability of l‑threonine aldolase from Pseudomonas putida via tailoring of the active sites lining the binding pocket
《Systems Microbiology and Biomanufacturing》2023年第3期440-448,共9页Lihong Li Rongzhen Zhang Wenchi Zhang Yan Xu 
the National Key research and Development Program of China(2018YFA0900302);the National Science Foundation of China(32271487,31970045);the National Firstclass Discipline Program of Light Industry Technology and Engineering(LITE2018-12);the Program of Introducing Talents of Discipline to Universities(111-2-06);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions.
l-threonine aldolases catalyze the conversion of glycine and aldehydes to synthesizeβ-hydroxy-α-amino acids with unsatisfactory enzyme activity.Here,we expressed the l-threonine aldolase from Pseudomonas putida KT24...
关键词：Threonine aldolases Pseudomonas putida Catalytic efficiency Thermostability Molecular dynamics simulations 
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2
《Frontiers of Medicine》2023年第3期503-517,共15页Mingyue Tan Qi Pan Qi Wu Jianfa Li Jun Wang 
financially supported by grants from the National Natural Science Foundation of China(Nos.82002683 and 81902569).
Aldolase B(ALDOB),a glycolytic enzyme,is uniformly depleted in clear cell renal cell carcinoma(ccRCC)tissues.We previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymatic act...
关键词：ALDOB kidney cancer cell proliferation 
Highly selective kinetic resolution of D/L-syn-p-sulfone phenylserine catalyzed by D-threonine aldolase in two-phase ionic solvent
《Green Chemical Engineering》2023年第2期212-216,共5页Fengfan Liu Zhihao Shi Jinmei Zhu Xiaobin Liang Mingming Liang Yuanyuan Xie Weike Su Jiequn Wu 
the Zhejiang Provincial Key R&D Project (Nos. 2020C03006 & 2019-ZJ-JS-03);National Key R&D Program of China (2021YFC2100800);the National Natural Science Foundation of China (Project 21808205);Research and Application Service Platform Project of API Manufacturing Environmental Protection and Safety Technology in China (2020-0107-3-1)。
In the chemical synthesis of L-syn-p-methylsulfoxide phenylserine ethyl ester(D-ethyl ester),L-tartaric acid or enzymatic resolution is employed to resolve the racemate,and thus obtain the target compound,and the rema...
关键词：Kinetic resolution Ionic solvent Enzymatic resolution D/L-p-sulphoxyl phenylserine ethyl ester Biphasic reaction system 
Hereditary fructose intolerance: A comprehensive review
《World Journal of Clinical Pediatrics》2022年第4期321-329,共9页Sumit Kumar Singh Moinak Sen Sarma 
Hereditary fructose intolerance(HFI)is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3.A fructose load leads to the rapid accumulation of...
关键词：HEREDITARY FRUCTOSE INTOLERANCE Children Liver STEATOHEPATITIS ALDOLASE 
Inhibiting lysosomal aldolase: a magic bullet for AMPK activation in treating metabolic disease?
《Life Metabolism》2022年第3期209-210,共2页David Carling 
In a tour-de-force study by Zhang et al.recently published in Nature Metabolism,a newly identified aldolase inhibitor,Aldometanib,is shown to activate lysosomal AMP-activated protein kinase(AMPK).Remarkably,mice treat...
关键词：LYSOSOMAL HOMEOSTASIS drugs 
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