云南高校图书馆联盟文献共享服务平台- LYASE

LYASE: 作品数：58被引量：163H指数：7; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：刘永军孙维佳李文旭胡天晓李苑更多>>; 相关机构：山东大学济宁学院桂林医学院附属医院中南大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金湖北省自然科学基金北京市自然科学基金国家教育部博士点基金更多>>

Cystathionineγ-lyase-derived H_(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase: 《Acta Pharmacologica Sinica》2024年第11期2366-2379,共14页You-tian Hu Zhi-wei Liu Tong-hui Zhang Yu-e Ma Lei He Jie Zhang Yue-yang Zhou Antonio Vidal-Puig De-jing Pan Fang Wu; supported by the National Natural Science Foundation of China(32271304,31500635,21834005,31771299);Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2021QN144);National Key R&D Program of China(2018YFA0801100);National Center for International Research of Genomics(2017B01012).; Thymic egress is a crucial process for thymocyte maturation,strictly regulated by sphingosine-1-phosphate lyase(S1PL).Recently,cystathionineγ-lyase(CSE),one of the enzymes producing hydrogen sulfide(H_(2)S),has emerg...; 关键词：immune cells thymic egress hydrogen sulfide S1P lyase redox motif NSC4056

miR-1202 regulates BPH-1 cell proliferation,apoptosis,and epithelial-to-mesenchymal transition through targeting HMGCL: 《Acta Biochimica et Biophysica Sinica》2024年第5期675-687,共13页Zhenting Wang Xianlai Yin Peng Yang Binghao Gong Haifang Liu; supported by the grants from the Natural Science Foundation of Hainan Province,China(No.822MS199);the Hainan Provincial Health Commission Project(No.20A200032);the Key Science and Technology Project of Haikou City(No.2022-031);the Finance Science and Technology Project of Hainan Province(No.ZDYF2019112).; Benign prostatic hyperplasia(BPH)is the expansion of the prostategland that results in urinary symptoms.Both the epithelial-to-mesenchymaltransition(EMT)and the Wnt signaling pathway are associated with BPHpathology.I...; 关键词：benign prostate hyperplasia(BPH) epithelial-to-mesenchymal transition(EMT) Wnt/β-catenin pathway miR-1202 3-hydroxy-3-methylglutaryl-CoA lyase(HMGCL)

Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma被引量：1: 《BIOCELL》2024年第3期463-471,共9页YANAN MA SHANSHAN WANG HUIGUO DING; This study was supported by Beijing Municipal Science&Technology Commission to Huiguo Ding(Z221100007422002);Beijing Hospitals Authority Youth Programme to Shanshan Wang(QML20211701).; Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality worldwide.Although cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors...; 关键词：Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide PROGNOSIS Apoptosis

A comprehensive review on microbial hyaluronan-degrading enzymes:from virulence factors to biotechnological tools: 《Bioresources and Bioprocessing》2024年第1期1492-1514,共23页Jia-Yu Jiang Dai Xue Jin-Song Gong Qin-Xin Zheng Yue-Sheng Zhang Chang Su Zheng-Hong Xu Jin-Song Shi; financially supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Taishan Industry Leading Talent of Shandong Province(No.tscx202211017);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_2575).; Hyaluronan(HA),a natural high molecular weight polysaccharide,has extensive applications in cosmetology and medical treatment.Hyaluronan-degrading enzymes(Hyals)act as molecular scissors that cleave HA by breaking the...; 关键词：Hyaluronan-degrading enzymes Hyaluronan lyase HYALURONIDASE Host invasion Disease development ANTI-BACTERIA Cancer therapy Hyaluronan degradation Hyaluronan detection

Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells:Role of cystathionineγ-lyase/hydrogen sulfide pathway被引量：5: 《World Journal of Stem Cells》2023年第11期1017-1034,共18页Bin Hu Xiang-Xi Zhang Tao Zhang Wan-Cheng Yu; the Natural Science Foundation of Shandong Province of China,No.ZR2021QH179 and ZR2020MH014.; BACKGROUND Ferroptosis can induce low retention and engraftment after mesenchymal stem cell(MSC)delivery,which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension(PAH)ther...; 关键词：Human umbilical cord mesenchymal stem cells Cystathionineγ-lyase/hydrogen sulfide pathway Ferroptosis Pulmonary arterial hypertension S-sulfhydration

Sphingosine phosphate lyase insufficiency syndrome:a systematic review: 《World Journal of Pediatrics》2023年第5期425-437,共13页Zahra Pournasiri Abbas Madani Fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh Fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee; Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...; 关键词：Nephrotic syndrome type 14 Immunodeficiency LYMPHOPENIA Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome

Isolation and Characterization of Contaminating Bacteria from Garcinia cambogia Extract: Methods to Reduce Microbial Load and Its Anti-Obesity Effect in Wistar Rats: 《Natural Resources》2022年第7期147-170,共24页Raj Kumar Bhosale Sasidharan Sakkan Srinivasa Murthy Venkatramanappa Shivaswamy Mathada Rudraiah Kumaraswamy Rampur Arulmozhi Sathiyanarayanan Deepa Mandlik Sanman Kolhe Sadanand Yewale Sriram Padmanabhan; Objectives: This study aimed to identify the contaminating bacteria in the extract of Garcinia cambogia, which is regularly used as a dietary supplement for addressing obesity in humans. Methods: The Garcinia cambogia...; 关键词：Garcinia cambogia Hydroxy Citric Acid Picrorhiza kurroa Liver Health ATP Citrate Lyase

17α-hydroxylase/17,20 carbon chain lyase deficiency caused by p.Tyr329fs homozygous mutation:Three case reports被引量：2: 《World Journal of Clinical Cases》2021年第8期1923-1930,共8页Dai Zhang Jian-Ran Sun Jiang Xu Yan Xing Mao Zheng Shan-Dong Ye Jie Zhu; Anhui Province Central Guided Local Science and Technology Development Funding Project,No.2017070802D147;Anhui Province Key Clinical Specialist Construction Fund.; p.Tyr329fs is a cytochrome P450c17 mutation among Chinese individuals.However,data on 17-α-hydroxylase deficiency caused by cytochrome P450c17 p.Tyr329fs homozygous mutation are lacking.This paper is a case report of...; 关键词：Cytochrome P450c17 17-α-hydroxylase-17 20-lyase deficiency Phenotype MUTATION Case report

S1P lyase在肝癌中的表达及对其预后的影响被引量：2: 《中国实验诊断学》2020年第6期887-891,共5页邱志东王雪红孙维佳金俊飞; 广东省自然科学基金资助项目(2018A0303130296)。; 目的探讨S1P lyase在肝癌中的表达情况,及其对肝癌预后的影响。方法选取桂林医学院附属医院54例肝细胞癌患者,real-time PCR分析S1P lyase在54对肝细胞癌癌组织及癌旁组织中的表达,运用统计学方法探讨S1P lyase表达与肝癌临床病理特征...; 关键词：S1P lyase 肝癌生物信息学预后

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases被引量：4: 《Neural Regeneration Research》2020年第4期653-662,共10页Rubaiya Tabassum Na Young Jeong Junyang Jung; supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, No. 2018R1A2B6001123 (to NYJ), No. 2018R1D1A1B07040282 (to JJ); Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease...; 关键词：3-mercaptopyruvate SULFURTRANSFERASE aging antioxidant cystathionineβ-synthase cystathionineγ-lyase GLUTATHIONE hydrogen sulfide NEURODEGENERATIVE disease oxidative stress reactive oxygen species

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