LYASE

作品数：58被引量：163H指数：7
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相关领域：医药卫生农业科学更多>>
相关作者：刘永军孙维佳李文旭胡天晓李苑更多>>
相关机构：山东大学济宁学院桂林医学院附属医院中南大学更多>>
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相关基金：国家自然科学基金湖北省自然科学基金北京市自然科学基金国家教育部博士点基金更多>>
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Cystathionineγ-lyase-derived H_(2)S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
《Acta Pharmacologica Sinica》2024年第11期2366-2379,共14页You-tian Hu Zhi-wei Liu Tong-hui Zhang Yu-e Ma Lei He Jie Zhang Yue-yang Zhou Antonio Vidal-Puig De-jing Pan Fang Wu 
supported by the National Natural Science Foundation of China(32271304,31500635,21834005,31771299);Research Fund of Medicine and Engineering of Shanghai Jiao Tong University(YG2021QN144);National Key R&D Program of China(2018YFA0801100);National Center for International Research of Genomics(2017B01012).
Thymic egress is a crucial process for thymocyte maturation,strictly regulated by sphingosine-1-phosphate lyase(S1PL).Recently,cystathionineγ-lyase(CSE),one of the enzymes producing hydrogen sulfide(H_(2)S),has emerg...
关键词：immune cells thymic egress hydrogen sulfide S1P lyase redox motif NSC4056 
Investigating the mechanisms of isochorismate synthase:An approach to improve salicylic acid synthesis and increase resistance to Fusarium head blight in wheat被引量：1
《The Crop Journal》2024年第4期1054-1063,共10页Ya-Zhou Zhang Jie Man Dan Xu Lan Wen Yinghui Li Mei Deng Qian-Tao Jiang Qiang Xu Guo-Yue Chen Yu-Ming Wei 
supported by the National Natural Science Foundation of China(3210170116);the Science and Technology Department of Sichuan Province(2022YFSY0035).
Salicylic acid(SA),a vital endogenous hormone,plays a crucial role in plant growth and the response to abiotic and biotic stress.Isochorismate synthase(ICS)and phenylalanine ammonia lyase(PAL)are critical rate-limitin...
关键词：Salicylic acid Chorismate Isochorismate RNA-SEQ Phenylalamine ammonia lyase 
Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis
《Engineering》2024年第7期144-154,共11页Jun-Su Zhou Long Cheng Yuan Gao Zhan-Peng Ge Bin Zhou Jing-Ya Li Jin-Xin Zhao Jian-Min Yue 
support from the National Natural Science Foundation of China(22237007 and 22177122);the Biological Resources Program of Chinese Academy of Sciences(CAS)(KFJ-BRP-008-001);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022282)is gratefully acknowledged.We thank Prof.Shi-Man Huang,Department of Biology,Hainan University,China,for the identification of the plant material.
Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-nam...
关键词：Norditerpenoid heterodimer Trigonostemon fragilis EUPHORBIACEAE Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(ACLY) inhibitory activity 
miR-1202 regulates BPH-1 cell proliferation,apoptosis,and epithelial-to-mesenchymal transition through targeting HMGCL
《Acta Biochimica et Biophysica Sinica》2024年第5期675-687,共13页Zhenting Wang Xianlai Yin Peng Yang Binghao Gong Haifang Liu 
supported by the grants from the Natural Science Foundation of Hainan Province,China(No.822MS199);the Hainan Provincial Health Commission Project(No.20A200032);the Key Science and Technology Project of Haikou City(No.2022-031);the Finance Science and Technology Project of Hainan Province(No.ZDYF2019112).
Benign prostatic hyperplasia(BPH)is the expansion of the prostategland that results in urinary symptoms.Both the epithelial-to-mesenchymaltransition(EMT)and the Wnt signaling pathway are associated with BPHpathology.I...
关键词：benign prostate hyperplasia(BPH) epithelial-to-mesenchymal transition(EMT) Wnt/β-catenin pathway miR-1202 3-hydroxy-3-methylglutaryl-CoA lyase(HMGCL) 
Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma被引量：1
《BIOCELL》2024年第3期463-471,共9页YANAN MA SHANSHAN WANG HUIGUO DING 
This study was supported by Beijing Municipal Science&Technology Commission to Huiguo Ding(Z221100007422002);Beijing Hospitals Authority Youth Programme to Shanshan Wang(QML20211701).
Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality worldwide.Although cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors...
关键词：Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide PROGNOSIS Apoptosis 
A comprehensive review on microbial hyaluronan-degrading enzymes:from virulence factors to biotechnological tools
《Bioresources and Bioprocessing》2024年第1期1492-1514,共23页Jia-Yu Jiang Dai Xue Jin-Song Gong Qin-Xin Zheng Yue-Sheng Zhang Chang Su Zheng-Hong Xu Jin-Song Shi 
financially supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Taishan Industry Leading Talent of Shandong Province(No.tscx202211017);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_2575).
Hyaluronan(HA),a natural high molecular weight polysaccharide,has extensive applications in cosmetology and medical treatment.Hyaluronan-degrading enzymes(Hyals)act as molecular scissors that cleave HA by breaking the...
关键词：Hyaluronan-degrading enzymes Hyaluronan lyase HYALURONIDASE Host invasion Disease development ANTI-BACTERIA Cancer therapy Hyaluronan degradation Hyaluronan detection 
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells:Role of cystathionineγ-lyase/hydrogen sulfide pathway被引量：5
《World Journal of Stem Cells》2023年第11期1017-1034,共18页Bin Hu Xiang-Xi Zhang Tao Zhang Wan-Cheng Yu 
the Natural Science Foundation of Shandong Province of China,No.ZR2021QH179 and ZR2020MH014.
BACKGROUND Ferroptosis can induce low retention and engraftment after mesenchymal stem cell(MSC)delivery,which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension(PAH)ther...
关键词：Human umbilical cord mesenchymal stem cells Cystathionineγ-lyase/hydrogen sulfide pathway Ferroptosis Pulmonary arterial hypertension S-sulfhydration 
Sphingosine phosphate lyase insufficiency syndrome:a systematic review
《World Journal of Pediatrics》2023年第5期425-437,共13页Zahra Pournasiri Abbas Madani Fatemeh Nazarpack John A.Sayer Zahra Chavoshzadeh Fatemeh Nili Paulina Tran Julie D.Saba Mahnaz Jamee 
Background Sphingosine-1-phosphate lyase insufficiency syndrome(SPLIS)or nephrotic syndrome type-14 is caused by biallelic mutations in SGPL1.Here,we conducted a systematic review to delineate the characteristics of S...
关键词：Nephrotic syndrome type 14 Immunodeficiency LYMPHOPENIA Sphingosine-1-phosphate lyase 1 Sphingosine-1-phosphate lyase insufficiency syndrome 
Purification and Characterization of Hyaluronate Lyases Produced by Two Types of Bacteria
《Agricultural Biotechnology》2023年第4期99-104,共6页Shuai LI Xinhui WANG Yota TATARA Shigeki HAMADA Takuya KOZEKI Kaoru KOJIMA Takashi YOSHIDA 
Hyaluronate lyases were obtained from two types of naturally isolated bacterial strains Paenibacillus yunnanensis and Paennarthrobacter nicotinovorans.PyHL(form P.yunnanensis)in the culture supernatant of the bacteria...
关键词：GLYCOSAMINOGLYCAN HYALURONAN Hyaluronate lyase Paenibacillus yunnanensis Paennarthrobacter nicotinovorans 
Isolation and Characterization of Contaminating Bacteria from Garcinia cambogia Extract: Methods to Reduce Microbial Load and Its Anti-Obesity Effect in Wistar Rats
《Natural Resources》2022年第7期147-170,共24页Raj Kumar Bhosale Sasidharan Sakkan Srinivasa Murthy Venkatramanappa Shivaswamy Mathada Rudraiah Kumaraswamy Rampur Arulmozhi Sathiyanarayanan Deepa Mandlik Sanman Kolhe Sadanand Yewale Sriram Padmanabhan 
Objectives: This study aimed to identify the contaminating bacteria in the extract of Garcinia cambogia, which is regularly used as a dietary supplement for addressing obesity in humans. Methods: The Garcinia cambogia...
关键词：Garcinia cambogia Hydroxy Citric Acid Picrorhiza kurroa Liver Health ATP Citrate Lyase 
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