LYASE

作品数：58被引量：163H指数：7
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相关作者：刘永军孙维佳李文旭胡天晓李苑更多>>
相关机构：山东大学济宁学院桂林医学院附属医院中南大学更多>>
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Enzymatic production of N‑acetylneuraminic acid:advances and perspectives
《Systems Microbiology and Biomanufacturing》2022年第1期130-146,共17页Muhammad Iftikhar Hussain Xiaolong Zhang Xueqin Lv Samra Basharat Umar Shahbaz Jianghua Li Guocheng Du Long Liu Yanfeng Liu 
This work was supported by the National Key Research and Development Program of China(2018YFA0900300);National Natural Science Foundation of China(31972854);Natural Science Foundation of Jiangsu Province(BK20200085);Key Research and Development Program of Jiangsu Province(BE2019628);Fundamental Research Funds for the Central Universities(JUSRP22036).
N-Acetyl-d-neuraminic acid(NeuAc),a well-known and well-studied sialic acid,is found in cell surface glycolipids and glycoproteins,where it performs a variety of biological functions.The use of NeuAc as a nutraceutica...
关键词：N-Acetyl-d-neuraminic acid Enzymatic synthesis N-Acetyl-d-neuraminic acid lyase N-Acetyl-glucosamine 2-epimerase 
The Promiscuous Activity of the Radical SAM Enzyme NosL toward Two Unnatural Substrates被引量：3
《Chinese Journal of Chemistry》2021年第9期2417-2421,共5页Yue Yin Xinjian Ji Qi Zhang 
supported in part by grants from the National Key Research and Development Program(2018Y F A0900402 and 2016Y F A0501302);from the National Natural Science Foundation of China(21822703 and 21921003).
The radical S-adenosyImethionine(SAM)enzyme NosL catalyzes the conversion of L-tryptophan((-Trp,1)to 3-methyl-2-indolic acid(MIA,2),a key in termediate in the biosynthesis of the peptide an tibiotic no siheptide.Previ...
关键词：BIOSYNTHESIS ANTIBIOTICS Cleavage reactions LYASE Enzyme catalysis 
Aryl hydrocarbon receptor signaling promotes ORMDL3- dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase被引量：1
《Cellular & Molecular Immunology》2019年第10期783-790,共8页Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-Yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang 
This work was supported,in part,by grants from the National Health Research Institutes,Taiwan(EOPP10-014 and EOSP07-014 to S.-K.H.);Kaohsiung Medical University“The Talent Plan”(105KMUOR04 to S.-K.H.);the Ministry of Science and Technology,Taiwan(MOST 105-2320-B-039-004 and MOST 106-2320-B-039-037,to H.-C.W.);China Medical University Hospital,Taiwan(DMR-106-154 and DMR-107-117,to H.-C.W.);the Community Medicine Research Center,Chang Gung Memorial Hospital at Keelung(CMRPG3E1183 to L.-C.C.);the 1000 Young Talents Plan Program,China(to Y.Z.);the Initial Funding for New PI,Fudan Children’s Hospital and Fudan University(to Y.Z.);the National Natural Science Foundation of China(81671561,to Y.Z.);the National Key Research and Development Program of China(2016YFC1305102,to Y.Z.)。
Aryl hydrocarbon receptor(AhR),a cellular chemical sensor,controls cellular homeostasis,and sphingosine-1-phosphate(S1P),a bioactive intermediate of sphingolipid metabolism,is believed to have a role in immunity and i...
关键词：Aryl hydrocarbon receptor ORMDL sphingolipid biosynthesis regulator 3 Sphingosine-1-phosphate Sphingosine-1-phosphate lyase 
Enzyme-mediated hydrolytic activation of prodrugs被引量：3
《Acta Pharmaceutica Sinica B》2011年第3期143-159,共17页Yan-hui Yang Herve Aloysius Daigo Inoyama Yu Chen Long-qin Hun 
Prodrug design is an important part of drug discovery.Prodrugs can offer many advantages over parent drugs such as increased solubility,enhanced stability,improved bioavailability,reduced side effects,and better selec...
关键词：PRODRUGS Hydrolytic activation TRANSFERASE HYDROLASE LYASE 
Effect of Chloride Ions and Dissolved Oxygen on the Deactivation of Phenylalanine Ammonia-lyase
《Chinese Science Bulletin》1994年第19期1620-1623,共4页李清彪 由英才 陶雪 何炳林 
With the method of synthesizing the L-phenylalanine by trans-cinnamic acid and ammonia in the presence of phenylalanine ammonialyase (PAL) under high pH and high concentration of cinnamic acid, it is not favorable for...
关键词：PHENYLALANINE ammonia-lyase DEACTIVATION L-PHENYLALANINE CHLORIDE ion dissolved oxygen. 
Inhibitory Effects of 20α-Hydroxyprogesterone on Steroid Hydroxylation Reactions of Guinea Pig Adrenal Microsomes
《Science China Chemistry》1993年第4期411-419,共9页黄德盈 Shiro Kominami Shigeki Takemori 
Using guinea pig andrenal microsomes, we studied the inhibitory effects of 20α-hydroxyprogesterone on steroid hydroxylation reactions catalyzed by cytochromes P-450. When 17α-hydroxyprogesterone was used as a substr...
关键词：cytochrome P-450_(c21) cytochrome P-450_(17α lyase ) 20α-hydroxyprogesterone adrenal microsome steroidogenesis. 
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