S-ADENOSYL-L-METHIONINE

作品数：7被引量：26H指数：2
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相关领域：生物学更多>>
相关作者：杨明华更多>>
相关机构：中国药科大学温州医学院更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《World Journal of Gastroenterology》《中国生物学文摘》更多>>
相关基金：国家自然科学基金更多>>
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Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization
《Science China Chemistry》2025年第1期308-316,共9页Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu 
supported in part by the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(32030002,22193070);the Shanghai Post-Doctoral Excellence Program(2022718)。
Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM)proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members.Many of these proteins are in...
关键词：cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation 
S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine's chemistry, physiology and pharmacokinetics被引量：2
《World Journal of Gastroenterology》2017年第40期7343-7346,共4页Dimitrios Tsikas Erik Hanff Alexander Bollenbach 
S-Adenosyl-L-methionine(SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to modify antioxidant-enzymes, glutathione-biosynthesis and methion...
关键词：S-ADENOSYL-L-METHIONINE BIOAVAILABILITY Concentration Liver 
S-adenosyl-L-methionine modifies antioxidant-enzymes,glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells被引量：2
《World Journal of Gastroenterology》2016年第14期3746-3757,共12页Sonia Amelia Lozano-Sepulveda Eduardo Bautista-Osorio Jose Angel Merino-Mascorro Marta Varela-Rey Linda Elsa Munoz-Espinosa Paula Cordero-Perez María Luz Martinez-Chantar Ana Maria Rivas-Estilla 
Supported by CONACYT-Mexico,grant register CB2010-01-155082 to Rivas-Estilla AM
AIM: To elucidate the mechanism(s) by which S-adenosyl-L-methionine(SAM) decreases hepatitis C virus(HCV) expression.METHODS: We examined the effects of SAM on viral expression using an HCV subgenomic replicon cell cu...
关键词：Hepatitis C virus S-ADENOSYL-L-METHIONINE Superoxide dismutase 1 Superoxide dismutase 2 Replication Hepatitis C virus-RNA NS5A Oxidative stress Antioxidants Viral proteins Reactive oxygen species Pyrrolidine dithiocarbamate 
S-adenosyl-L-methionine, trehalose and oleanolic acid in few plants
《Health》2010年第8期968-972,共5页Dipankar Malakar Paramita Chaudhuri Trina Dutta Anil K Ghosh 
S-Adenosyl-L-Methionine (AdoMet), S-Adenosyl- L-Homocysteine (AdoHcy), adenosine, trehalose and oleanolic acid were measured in six medicinal herbs and three spices. The findings showed that AdoMet content was forty s...
关键词：ADOMET AdoHcy ADENOSINE TREHALOSE Oleanolic Acid 
Hepatoprotective effects of S-adenosyl-L-methionine against alcohol-and cytochrome P450 2E1-induced liver injury被引量：24
《World Journal of Gastroenterology》2010年第11期1366-1376,共11页Arthur I Cederbaum 
Supported by NIH/NIAAA Grants No. AA017425;Supported by NIH/NIAAA Grants No. AA018790
S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death...
关键词：Cytochrome P450 2E1 S-ADENOSYL-L-METHIONINE ETHANOL Toxic hepatitis Oxidative stress 
A synergistic effect on the production of S-adenosyl-L-methionine in Pichia pastoris by knocking in of S-adenosyl-L-methionine synthase and knocking out of cystathionine-beta synthase
《中国生物学文摘》2007年第10期13-14,共2页He, JY Deng, JJ Zheng, YH Gu, J 
关键词：β-丙氨酸丁氨酸硫醚合酶 增效作用 腺苷甲硫氨酸 腺苷甲硫氨酸合酶 基因 植物 
Effect of DNA methylation on protein-DNA interaction of HL-60 cells
《Science China(Life Sciences)》1999年第5期501-505,共5页何忠效 白坚石 张昱 
HL-60 cells have been induced with differentiation index 16% by S-adenosyl-L-methionine (SAM) as in-ducer in the presence of optimum concentration of 10 μmol/L. The methylation level of genome DNA determined by HPLC ...
关键词：S-ADENOSYL-L-METHIONINE (SAM) HL-60 cell DNA METHYLATION PROTEIN-DNA interaction. 
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