-LACTAM

作品数：12被引量：10H指数：2
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相关领域：理学医药卫生更多>>
相关作者：陈磊更多>>
相关机构：中国科学院河北大学更多>>
相关期刊：《Chinese Journal of Structural Chemistry》《合成化学》《Science China Chemistry》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金中国博士后科学基金上海市自然科学基金上海市青年科技启明星计划更多>>
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Enantioselective Synthesis ofα-Alkenylatedγ-Lactam Enabled by Ni-Catalyzed 1,4-Arylcarbamoylation of 1,3-Dienes被引量：2
《CCS Chemistry》2023年第2期341-349,共9页Feng He Liting Hou Xianqing Wu Haojie Ding Jingping Qu Yifeng Chen 
supported by National Natural Science Foundation of China(grant no.22171079);the Natural Science Foundation of Shanghai(grant no.21ZR1480400);the Shanghai Rising-Star Program(grant no.20QA1402300);the Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities(grant no.B16017);the Fundamental Research Funds for the Central Universities and the China Postdoctoral Science Foundation(grant no.2021M701197).
The facile construction of chiral quaternaryα-alkenylated pyrrolidinones is a long-term challenge in organic synthesis.The asymmetric difunctionalization of 1,3-dienes represents the most compelling tool for assembli...
关键词：LACTAM NICKEL 1 3-diene enantioselective dicarbofunctionalization quaternary stereogenic center 
Epidemiology and Mechanisms of Ceftazidime-Avibactam Resistance in Gram-Negative Bacteria被引量：3
《Engineering》2022年第4期138-145,共8页Tingting Xu Yuqi Guo Yang Ji Baohong Wang Kai Zhou 
supported by the National Key Research and Development Program of China (2017YFC1200200);Major Infectious Diseases such as AIDS and Viral Hepatitis Prevention and Control Technology Major Projects (2018ZX10712-001);National Natural Science Foundation of China (81702045 and 81902030);Shenzhen Basic Research projects (JCYJ20190807144409307)
Carbapenem resistance presents a major challenge for the global public health network, as clinical infections caused by carbapenem-resistant organisms(CRO) are frequently associated with significant morbidity and mort...
关键词：Ceftazidime-avibactam Resistance mechanism CARBAPENEM-RESISTANT b-lactam/b-lactamase inhibitor 
Visible-light-promoted Radical Cyclization/Arylation Cascade for the Construction of α,α-Difluoro-γ-Lactam-Fused Quinoxalin-2(1H)-Ones被引量：2
《Chinese Journal of Chemistry》2022年第6期713-718,共6页Yun-Chao Zhang Yang Chen Jing Sun Jing-Yun Wang Ming-Dong Zhou 
We thank the National Natural Science Foundation of China(No.21101085);the Natural Science Foundation of Liaoning Province(No.2015020196);the Liaoning Revitalization Talents Program(No.XLYC1902085);the PetroChina Innovation Foundation(No.2018D-5007-0507);the Research Project Fund of Liaoning Provincial Department of Education(No.L2019037)for the financial supports.
A visible-light-induced tandem radical intramolecular cyclization/arylatiion of quinoxalin-2(1H)-ones with bromodifluoroacetamides is described.This protocol allows efficient access to a variety of valuableα,α-diflu...
关键词：Photocatalysis Cyclization Radicals Fluoro-γ-lactams Quinoxalin-2(1H)-ones 
Copper catalyzed borylative cyclization of 3-arylallyl carbamoyl chloride with B_(2)pin_(2):stereoselective synthesis of cis-2-aryl-3-boryl-γ-lactams
《Chinese Chemical Letters》2021年第7期2297-2300,共4页Mei-Hua Shen Ting-Biao Wan Xiu-Rong Huang Yan Li Dan-Hua Qian Hua-Dong Xu Defeng Xu 
the National Natural Science Foundation of China(No.21672027)for financial support;supported by High-Level Entrepreneurial Talent Team of Jiangsu Province(No.2017-37)。
Borylative cyclization of E-3-arylallyl carbamoyl chlorides is achieved through copper catalyzed intramolecular carboboration with B_(2)pin_(2).2-Aryl-3-boryl-γ-lactams are formed with exclusive cisdiastereoselectivi...
关键词：Carboboration Borylative cyclization Copper catalysis Allyl carbamoyl chloride Borocupration γ-Lactam 
Carbene-catalyzed activation of cyclopropylcarbaldehydes for mannich reaction andδ-lactam formation:remote enantioselecitvity control and dynamic kinetic asymmetric transformation被引量：1
《Science China Chemistry》2021年第6期985-990,共6页Jie Lv Jun Xu Xuling Pan Zhichao Jin Yonggui Robin Chi 
This work was supported by the National Natural Science Foundation of China(21772029,21801051,21961006,22071036,82360589,81360589);The 10 Talent Plan(Shicengci)of Guizhou Province([2016]5649);the Guizhou Province Returned Oversea Student Science and Technology Activity Program[(2014)-2];the Science and Technology Department of Guizhou Province([2018]2802,[2019]1020);the Program of Introducing Talents of Discipline to Universities of China(111 Program,D20023);at Guizhou University,Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province[Qianjiaohe KY(2020)004];the Guizhou Province First-Class Disciplines Project[(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008];Guizhou University of Traditional Chinese Medicine(China),and Guizhou University.
An N-heterocyclic carbene(NHC)-catalyzed enantioselective Mannich reaction of the remoteγ-carbon of cyclopropylcarbaldehydes is disclosed for the first time.Diastereo-and enantiomerically enriched multicyclicδ-lacta...
关键词：N-heterocyclic carbene ORGANOCATALYSIS dynamic kinetic asymmetric transformation 1-cyclopropylcarbaldehydes asymmetric reactions 
Design and synthesis of novel triazole derivatives containing γ-lactam as potential antifungal agents
《Chinese Chemical Letters》2016年第5期703-706,共4页Yuan-Yuan Xu An-Ran Qian Xu-Feng Cao Chen-Yu Ling Yong-Bing Cao Rui-Lian Wang Yi-Su Li Yu-She Yang 
supported by the National Natural Science Foundation of China (No. 21402223)
A series of novel triazole derivatives containing y-lactam were designed and synthesized, and their structures were confirmed by IH NMR, 13C NMR and HRMS, The in vitro antifungal activities of the target compounds wer...
关键词：Synthesis Triazole γ-Lactam Antifungal activity 
A Convenient Method for the Preparation of 1,5-Diaryl-3-（arylamino）-I H-pyrrol-2（5 H）-ones被引量：1
《Chinese Journal of Chemistry》2011年第9期1851-1855,共5页Ghashang, Majid Shaterian, Hamid Reza~ 
A simple and eco-friendly method for the preparation of 1,5-diaryl-3-（arylamino）-lH-pyrrol-2（5H）-ones via the cyclo-condensation reaction of aldehydes, amines and ethyl pyruvate in the presence of silica supported...
关键词：multicomponent reactions domino reactions SiO2-FeCl3 1 5-diaryl-3-（arylamino）-lH-pyrrol-2（5H）-one γ-lactam ethyl pyruvate 
Michael addition reactions of cyclanones with acrylamides:Producing 2-carbamoylethyl derivatives or ene-lactams
《Science China Chemistry》2008年第11期1044-1050,共7页DAI WeiFeng WANG ChaoHua ZHANG Xi ZHANG JinMing LANG MeiDong 
the National Natural Science Foundation of China (Grant Nos. 20374013 and 20674019);Program for New Century Excellent Talents in University (Grant No. NCET-04-0413);Science and Technology Commission of Shanghai Municipality (Grant Nos. 03JC14023 and 05DJ14005);"Shu Guang" Project of Shanghai Municipal Education Commission and Specialized Research Fund for the Doctoral Program of Higher Education (Grant No.20060251015)
The electron-withdrawing groups (EWGs) in the electrophilic alkenes employed in the Michael addition reaction are almost only CO2R, CN, COR, NO2, and SO2Ph. Although amides (CONR1R2) are also typical electron-withdraw...
关键词：MICHAEL addition reaction cyclanone ACRYLAMIDE ene-lactam 2-carbamoylethyl derivative 
A concise synthesis of (±)-pregabalin via intramolecular C-H insertion of N-cumyl á-diazoacetamide被引量：1
《合成化学》2004年第z1期31-31,共1页CHEN Zhen-liang LIU Wei-jun CHEN Zhi-yong Jiang Yao-zhong HU Wen-hao 
Supported by the National Science Foundation of China (Grant No. 20202011) and the ChineseAcademy of Sciences
关键词：Pregabalin  C-H insertion (a)-lactam 
Solid-Phase Total Synthesis of 1-β-Methylcarbapenem
《Chinese Chemical Letters》2003年第1期6-8,共3页Ming LEI Cheng MA Yan Guang WANG 
This work was financially supported by the National Natural Science Foundation of China (No. 29972037).
A 1-b-methylcarbapenem analogue 6 was synthesized on polystyrene-diethylsilane resin (PS-DES) using 2-azetidinone bearing with 2-oxazolidone chiral auxiliary as starting material.
关键词：SOLID-PHASE synthesis of b-lactam carbapenem antibiotics. 
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