HEMOGLOBIN

作品数:388被引量:456H指数:9
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相关作者:苏燕魏春华安亮李晓晶杜晓红更多>>
相关机构:包头医学院中国人民解放军中国医学科学院北京协和医学院中国中医研究院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金广东省自然科学基金更多>>
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GCH1 plays a role in the high-altitude adaptation of Tibetans被引量:9
《Zoological Research》2017年第3期155-162,共8页Yong-Bo Guo Yao-Xi He Chao-Ying Cui Ouzhuluobu Baimakangzhuo Duojizhuoma Dejiquzong Bianba Yi Peng Cai-juan Bai Gonggalanzi Yong-Yue Pan Qula Kangmin Cirenyangji Baimayangji Wei Guo Yangla Hui Zhang Xiao-Ming Zhang Wang-Shan Zheng Shu-Hua Xu Hua Chen Sheng-Guo Zhao Yuan Cai Shi-Ming Liu Tian-Yi Wu Xue-Bin Qi Bing Su 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000);the National Natural Science Foundation of China(91631306 to BS,31671329 to XQ,31460287 to Ou.,31501013 to HZ and 31360032 to CC);the National 973 program(2012CB518202 to TW);the State Key Laboratory of Genetic Resources and Evolution(GREKF15-05,GREKF16-04);the Zhufeng Scholar Program of Tibetan University
Tibetans are welt adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene (GCH1, GTP-cyc...
关键词:GCH1 Positive selection TibetanHypoxia adaptation Nitric oxide HemoglobinOxygen saturation 
Small-angle X-ray scattering probe of intermolecular interaction in red blood cells
《Chinese Physics C》2015年第3期83-86,共4页刘广峰 王文佳 徐建华 董宇辉 
Supported by National Basic Research Program of China(2009CB918600);National Natural Science Foundation of China(10979005)
With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentratio...
关键词:small-angle X-ray scattering protein-protein interaction HEMOGLOBIN 
Photolyses of mammalian carboxy-hemoglobin studied by photoacoustic calorimetry
《Science China(Physics,Mechanics & Astronomy)》2013年第7期1301-1309,共9页ZHAO JinYu LI JiaHuang ZHANG Zheng ZHANG ShuYi QU Min FANG JianWen HUA ZiChun 
supported by the National Natural Science Foundation of China(Grant No. 11074125);the National Basic Research Program of China(Grant No. 2012CB921504);the Foundamental Research Founds for Central Universities of China(Grant No. 1101020402);PAPD Project of Jiangsu Higher Education Institutions
The enthalpy and conformational volume changes in the photolyses of carboxy-hemoglobin (HbCO) of human, bovine, pig, horse and rabbit are investigated by photoacoustic calorimetry. Considering the time scales of the e...
关键词:photoacoustic calorimetry PHOTOLYSIS enthalpy change conformational volume change carboxy-hemoglobin 
Immobilization and Bioelectrochemistry of Hemoglobin Based on Carrageenan and Room Temperature Ionic Liquid Composite Film
《Chinese Journal of Chemistry》2012年第7期1565-1570,共6页盛春 张洋 王璐 贾能勤 
A novel biopolymer/room-temperature ionic liquid composite film based on carrageenan, room temperature ionic liquid (IL) [1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4)] was explored for immobilization ...
关键词:CARRAGEENAN room temperature ionic liquid HEMOGLOBIN direct electrochemistry 
Study on specific interaction of new ferrocene-substituted carborane conjugates with hemoglobin protein被引量:1
《Science China Chemistry》2012年第4期594-603,共10页WU ChunHui1,3, YE HongDe2, JIANG Hui1, WANG XueMei1 & YAN Hong2 1State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, Nanjing 210096, China 2State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China 3School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China 
supported by the National Basic Research Program of China (2010CB732404, 2010CB923303);the National Natural Science Foundation of China (21175020, 90713023, 20925104);the Project of High Technology Research and Development Program of China (2007AA022007);Gongdong Province (2011B090400357);the Natural Science Foundation of Jiangsu Province (BK2008149, BK2010052);C. W. acknowledges the Fundamental Research Funds for the Central Universities (ZYGX2011J099);the support by the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University (2011E09)
The interactions between the new organometallic complexes, ferrocenesubstituted dithioocarborane conjugates (denoted as FcSB1, FcSB2 and FcSBCO) and hemoglobin (Hb) are investigated by electrochemistry, fluorescen...
关键词:fluorescence  UV vis absorption spectroscopy  differential pulse voltammetry  biomolecular interaction  ferrocene substituted carborane conjugates  hemoglobin 
Direct Electrochemistry Transfer and Electrocatalysis of Hemoglobin Immobilized in Porous Mn_2O_3
《Chemical Research in Chinese Universities》2011年第2期291-294,共4页SHI Lin-pu GAO Qiu-ming 
Supported by the National Basic Research Program of China(No.2011CB935700);the National Natural Science Foundation of China(No.U0734002)
Novel porous Mn2O3 with good crystallinity was synthesized via hard-template method. Hb-Mn2O3 na-nocomposite was prepared and used for biosensor construction. The Hb-Mn2O3-Nafion modified electrode shows fast direct e...
关键词:Porous Mn203 BIOSENSOR Direct electrochemistry ELECTROCATALYSIS HEMOGLOBIN 
Theoretical study of interactions between human adult hemoglobin and acetate ion by polarizable force field and fragmentation quantum chemistry methods
《Science China Chemistry》2009年第11期1925-1931,共7页YAN XiuFen JIANG Nan MA Jing 
Supported by the National Natural Science Foundation of China (Grant No. 20825312);National Basic Research Program (Grant No. 2004CB719901);the Fok Ying Tong Education Foundation (Grant No. 111013)
A series of theoretical approaches,including conventional FF03 and FF03-based polarization model,as well as the generalized energy-based fragmentation(GEBF) quantum chemistry method,have been applied to investigate th...
关键词:polarization model FRAGMENTATION QM method HEMOGLOBIN interaction 
Dynamin like protein 1 participated in the hemoglobin uptake pathway of Plasmodium falciparum被引量:1
《Chinese Medical Journal》2009年第14期1686-1691,共6页ZHOU Hong-chang GAO Yu-hui ZHONG Xiang WANG Heng 
This work was supported by the research grants from the National Basic Research Program of China (973 Program, No. 2007CB513100), the High-Tech Research and Development Program of China (863 Program, No. 2006AA028471), the China's Major Infectious Diseases of Major Special Program (No. 2008ZX10004-011), and the grant of National Natural Science Foundation of China (No. 30170876).
Background During the blood stage of malaria infection, parasites internalize in the host red blood cells and degrade massive amounts of hemoglobin for their development. Although the morphology of the parasite's hem...
关键词:Plasmodium falciparum hemoglobin uptake DYNAMIN INHIBITOR 
Amelioration of β^(654)-thalassemia in mouse model with the knockdown of aberrantly spliced β-globin mRNA被引量:1
《Journal of Genetics and Genomics》2008年第10期595-601,共7页Shuyang Xie Wei Li Zhaorui Ren Jingzhi Zhang Xinbin Guo Shu Wang Shuzhen Huang Fanyi Zeng Yi-Tao Zeng 
the National Basic Research Program of China (973 Program) (No 2004CB518806);the National High-tech R&D Program (863 Program) (No 2007AA021206);the National Natural Science Foundation of China (No 30571777);the Chinese National and Shanghai Leading Academic Disci-pline Project (No B204)
Large amounts of aberrantly spliced mRNA from the β^654 allele was present in erythroid cells, which might impair the erythropoiesis. A therapeutic strategy for β-thalassemia was explored by knocking down the aberra...
关键词:Β-THALASSEMIA small interfering RNA (siRNA) HEMOGLOBIN 
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