supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13010000);the National Natural Science Foundation of China(91631306 to BS,31671329 to XQ,31460287 to Ou.,31501013 to HZ and 31360032 to CC);the National 973 program(2012CB518202 to TW);the State Key Laboratory of Genetic Resources and Evolution(GREKF15-05,GREKF16-04);the Zhufeng Scholar Program of Tibetan University
Tibetans are welt adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene (GCH1, GTP-cyc...
Supported by National Basic Research Program of China(2009CB918600);National Natural Science Foundation of China(10979005)
With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentratio...
supported by the National Natural Science Foundation of China(Grant No. 11074125);the National Basic Research Program of China(Grant No. 2012CB921504);the Foundamental Research Founds for Central Universities of China(Grant No. 1101020402);PAPD Project of Jiangsu Higher Education Institutions
The enthalpy and conformational volume changes in the photolyses of carboxy-hemoglobin (HbCO) of human, bovine, pig, horse and rabbit are investigated by photoacoustic calorimetry. Considering the time scales of the e...
A novel biopolymer/room-temperature ionic liquid composite film based on carrageenan, room temperature ionic liquid (IL) [1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4)] was explored for immobilization ...
supported by the National Basic Research Program of China (2010CB732404, 2010CB923303);the National Natural Science Foundation of China (21175020, 90713023, 20925104);the Project of High Technology Research and Development Program of China (2007AA022007);Gongdong Province (2011B090400357);the Natural Science Foundation of Jiangsu Province (BK2008149, BK2010052);C. W. acknowledges the Fundamental Research Funds for the Central Universities (ZYGX2011J099);the support by the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University (2011E09)
The interactions between the new organometallic complexes, ferrocenesubstituted dithioocarborane conjugates (denoted as FcSB1, FcSB2 and FcSBCO) and hemoglobin (Hb) are investigated by electrochemistry, fluorescen...
Supported by the National Basic Research Program of China(No.2011CB935700);the National Natural Science Foundation of China(No.U0734002)
Novel porous Mn2O3 with good crystallinity was synthesized via hard-template method. Hb-Mn2O3 na-nocomposite was prepared and used for biosensor construction. The Hb-Mn2O3-Nafion modified electrode shows fast direct e...
Supported by the National Natural Science Foundation of China (Grant No. 20825312);National Basic Research Program (Grant No. 2004CB719901);the Fok Ying Tong Education Foundation (Grant No. 111013)
A series of theoretical approaches,including conventional FF03 and FF03-based polarization model,as well as the generalized energy-based fragmentation(GEBF) quantum chemistry method,have been applied to investigate th...
This work was supported by the research grants from the National Basic Research Program of China (973 Program, No. 2007CB513100), the High-Tech Research and Development Program of China (863 Program, No. 2006AA028471), the China's Major Infectious Diseases of Major Special Program (No. 2008ZX10004-011), and the grant of National Natural Science Foundation of China (No. 30170876).
Background During the blood stage of malaria infection, parasites internalize in the host red blood cells and degrade massive amounts of hemoglobin for their development. Although the morphology of the parasite's hem...
the National Basic Research Program of China (973 Program) (No 2004CB518806);the National High-tech R&D Program (863 Program) (No 2007AA021206);the National Natural Science Foundation of China (No 30571777);the Chinese National and Shanghai Leading Academic Disci-pline Project (No B204)
Large amounts of aberrantly spliced mRNA from the β^654 allele was present in erythroid cells, which might impair the erythropoiesis. A therapeutic strategy for β-thalassemia was explored by knocking down the aberra...