DEOXYPODOPHYLLOTOXIN

作品数：4被引量：0H指数：0
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相关领域：医药卫生化学工程更多>>
相关期刊：《Chemical Research in Chinese Universities》《Medicinal Plant》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I
《Acta Pharmacologica Sinica》2023年第9期1906-1919,共14页Xuan-zhong Wang Shi-peng Liang Xi Chen Zhen-chuan Wang Chen Li Chun-sheng Feng Shan Lu Chuan He Yu-bo Wang Guang-fan Chi Peng-fei Ge 
supported by National Natural Science Foundation of China (81772669,81972346 and 82173027);Scientific Research Foundation of Jilin Province (20200201405JC);Collaboration Fund of the First Hospital of Jilin University and Changchun Institute of Applied Chemistry,Chinese Academy of Sciences (2022YYGFZJC011).
Parthanatos is a type of programmed cell death initiated by over-activated poly(ADP-ribose)polymerase 1(PARP1).Nuclear translocation of apoptosis inducing factor(AIF)is a prominent feature of parthanatos.But it remain...
关键词：GLIOMA DEOXYPODOPHYLLOTOXIN parthanatos apoptosis inducing factor(AIF) TAX1BP1 mitochondrial respiratory chain complexI 
Anti-tumor,Anti-allergy,Anti-angiogenesis and Hepatoprotective Effects of Deoxypodophyllotoxin and Its Molecular Mechanism
《Medicinal Plant》2023年第2期81-83,89,共4页Jingchao WANG Mingxinzhi WANG Quan QUAN Hai CHEN Anqi WANG Chenghao JIN 
Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16);Innovation and Entrepreneurship Training Program for College Students in Heilongjiang Province(202210223048)。
Deoxypodophyllotoxin not only has pharmacological effects such as anti-allergy,anti-angiogenesis and liver protection,but also has good anti-tumor activity.It can play an anti-tumor role by inhibiting cell viability,i...
关键词：DEOXYPODOPHYLLOTOXIN ANTI-TUMOR ANTI-ALLERGY ANTI-ANGIOGENESIS Liver protection 
Optimization and characterization of deoxypodophyllotoxin loaded mPEG-PDLLA micelles by central composite design with response surface methodology
《Chinese Journal of Natural Medicines》2018年第6期471-480,共10页YU Ying-Lan LI Ya-Nan ZHANG Yong SUN Ru-Ning TU Jia-Sheng SHEN Yan 
supported by the Ministry of Science and Technology of China(No.2014ZX09507001006);the National Natural Science Foundation of China(No.81501579);the Natural Science Foundation of Jiangsu Province(No.BK20150702);the Science and Technology Development Fund of Nanjing Medical University(No.2016NJMU105);the Priority Academic Program Development of Jiangsu Higher Education Institutions
The therapeutic application of deoxypodophyllotoxin(DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers(m PEG-PDLLA) were co...
关键词：DEOXYPODOPHYLLOTOXIN CENTRAL COMPOSITE design Micelles CYTOTOXICITY 
Synthesis and Biological Activity of Novel Spin Labeled Derivatives of 4′-Demethyl-4-deoxypodophyllotoxin
《Chemical Research in Chinese Universities》2010年第5期753-756,共4页XU Jing SUN Xiao-hua ZHANG Jia-qiang ZHANG Zhi-wei TIAN Xuan 
Supported by the State Key Laboratory of Applied Organic Chemistry, Lanzhou University, China(2009)
Seven novel spin labeled derivatives of 4＇-demethyl-4-deoxypodophyllotoxin with nitroxyl radi- cals（TMHPO and TMPRO） were prepared and their cytotoxic and antioxidative activities were tested. Their cytotoxic activ...
关键词：4＇-Demethyl-4-deoxypodophyllotoxin Nitroxyl radical Antiturnor activity Antioxidative activity 
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