ALPHA-KETOGLUTARATE

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Exogenous Alpha-Ketoglutarate(AKG)Modulate Physiological Characteristics,Photosynthesis,Secondary Metabolism and Antioxidant Defense System in Peganum Harmala L.under Nickel Stress
《Phyton-International Journal of Experimental Botany》2025年第1期137-155,共19页Marwa Rezgui Wided Ben Ammar Muhammad Nazim Walid Soufan Chiraz Chaffei Haouari 
Researchers Supporting Project No.(RSP2025R390),King Saud University,Riyadh,Saudi Arabia.
Nickel(Ni)toxicity significantly impairs plant growth,photosynthesis,and metabolism by inducing oxidative stress.This study evaluates the potential of exogenous Alpha-Ketoglutarate(AKG)in mitigating Ni-induced stress ...
关键词：ALPHA-KETOGLUTARATE antioxidative enzymes oxidative stress Peganum harmala NICKEL 
Qiteng Xiaozhuo granules(芪藤消浊颗粒)medicated serum inhibits excessive proliferation and promotes apoptosis of human glomerular mesangial cells by targeting fat mass and obesity associated proteins
《Journal of Traditional Chinese Medicine》2023年第6期1072-1080,共9页ZHUANG Xingxing LIU Tao WEI Liangbing SONG Junmei GAO Jiarong 
National Natural Science Foundation of China:Lnc NONRATG001910.2 Competitively Binds miR-339 to Regulate the Mechanism of Syk Involvement in the Pathogenesis of Chronic Nephritis and the Intervention of Qiteng Xiaozhuo Particles (No.81973546);the Key Scientific Research Projects of Natural Science in Colleges and Universities in Anhui Province:Study on the Mechanism of FTO-Mediated FOXO6 mRNA m6A Modification Regulating the Proliferation and Apoptosis of Glomerular Mesangial Cells (No.2022AH050747);Natural General Projects of Chaohu University:Expression and Target Analysis of miR-155-5p in Kidney Tissue of CGN Rats (No.XLY-201912)
OBJECTIVE:To explore whether fat mass and obesity associated proteins(FTO) is an important target of Qiteng Xiaozhuo granules(QTXZG,芪藤消浊颗粒) medicated serum in regulating proliferation and apoptosis of glomerular...
关键词：Qiteng Xiaozhuo granules alpha-ketoglutaratedependent dioxygenase FTO medicated serum cell proliferation apoptosis 
Metabolite alpha-ketoglutarate:a novel target of gasdermin C-dependent pyroptosis
《Chinese Medical Journal》2023年第13期1630-1631,共2页Yao Zhang Wu Jian Lu He Jianhua Wu 
National Natural Science Foundation of China(No.81803535);Natural Science Foundation of Hunan Province(No.2018JJ6070)
To the Editor:Tumors are one of the main causes of death worldwide.Pyroptosis is a newly discovered form of cell death,causing cell swelling and rapid lysis,which releases pro-inflammatory mediators and enhances the i...
关键词：IMMUNITY DEATH damage 
The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism
《Liver Research》2020年第2期94-100,共7页Katsuya Nagaoka Joud Mulla Kevin Cao Zhixiang Cheng Dan Liu William Mueller Amalia Bay Grace Hildebrand Shaolei Lu Chiung-Kuei Huang 
Funding for this work was provided by 2017 AASLDF Pinnacle Research Development Award and Rhode Island Foundation#134279.
Background:Non-alcoholic liver disease is of increased concern and contributing to economic burdens not only in developing countries but in developed countries as well.Identifying the biomarker of early diagnosis and ...
关键词：Peroxisome proliferator-activated receptor gamma(PPARγ) STEATOSIS Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) Alpha-ketoglutarate(a-KG) Gender difference C57BL/6 mouse 
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