APREPITANT

作品数：11被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：李平更多>>
相关机构：中山大学浙江理工大学暨南大学附属第一医院更多>>
相关期刊：《国外药讯》《世界临床药物》《Open Journal of Anesthesiology》《Journal of Cancer Therapy》更多>>
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Validation of different personalized risk models of chemotherapy-induced nausea and vomiting:results of a randomized,double-blind,phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin被引量：4
《Cancer Communications》2023年第2期246-256,共11页Yuanyuan Zhao Bing Zhao Gang Chen Yinlan Chen Zijun Liao Haiming Zhang Weineng Feng Yinyin Li Heng Weng Weidong Li Yuefen Zhou Biyong Ren Yanda Lu Jianhua Chen Zhenteng Liu Zhenzhong Su Wenliang Wang Li Zhang 
Background:Highly emetogenic chemotherapy induces emesis in cancer patients without prophylaxis.The purpose of this study was to evaluate the efficacy and safety of a fosaprepitant-based triple antiemetic regimen for ...
关键词：APREPITANT chemotherapy-induced nausea and vomiting clinical trial fosaprepitant neurokinin-1 receptor antagonists NOMOGRAM NOMOGRAM personalized risk model 
Computational study of some potential inhibitors of COVID-19:A DFT analysis
《Quantitative Biology》2022年第4期341-350,共10页Prabhat Ranjan Kumar Gaurav Tanmoy Chakraborty 
We would like to thank Manipal University Jaipur and Sharda University for providing computational facilities and research support.
Background:There is an urgent demand of drug or therapy to control the COVID-19.Until July 22,2021 the worldwide total number of cases reported is more than 192 million and the total number of deaths reported is more ...
关键词：COVID-19 repurposing drug density functional theory HOMO-LUMO EPIRUBICIN APREPITANT 
Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies
《Cancer Biology & Medicine》2021年第3期825-832,共8页Winnie Yeo Leung Li Thomas KH Lau Kwai T Lai Vicky,TC Chan Kwan H Wong Christopher CH Yip Elizabeth Pang Maggie Cheung Vivian Chan Carol CH Kwok Joyce JS Suen Frankie KF Mo 
supported by an education grant from Madam Diana Hon Fun Kong Donation for Cancer Research(Grant No.7104870)。
Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)chemotherapy.Recommended antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytrypta...
关键词：Netupitant PALONOSETRON APREPITANT OLANZAPINE NEPA Asians 
Possible Mechanism of Action of Neurokinin-1 Receptors （NK1R） Antagonists
《Journal of Pharmacy and Pharmacology》2017年第11期787-797,共11页Ozum Ozturk Esin Aki-Yalcin Tugba Ertan-Bolelli Kayhan Bolelli Andry Nur-Hidayat Ozlem Bingol-Ozakpinar Filiz Ozdemir Ismail Yalcin 
Recently, NK1R （Neurokinin-1 receptors） take attention as new and promising target in anticancer drug development area. It has been proved that non-peptide NK1R antagonists L-733,060, aprepitant and L-732,138 inhibi...
关键词：ANTICANCER APREPITANT BENZOTHIAZOLE docking NK1 receptor antagonist pharmacophore. 
The use of aprepitant and palonosetron in preventing chemotherapy-related nausea and vomiting inlung cancer patients
《Oncology and Translational Medicine》2017年第3期108-110,共3页Shuxian Qu Zhendong Zheng Zhaozhe Liu Jianing Qiu Xiaodong Xie 
Objective The aim of this study was to explore the clinical efficacy and toxicity of a combination aprepitant and palonosetron hydrochloride therapy in preventing chemotherapy-induced nausea and vomiting associated wi...
关键词：aprepitant palonosetron hydrochloride capsule cisplatinum tropisetron 
Prevention of Postoperative Nausea and Vomiting in Elective Hysterectomy: A Prospective, Randomized, Placebo Controlled Outcomes Trial of Aprepitant NK-1-Receptor Antagonist被引量：1
《Open Journal of Anesthesiology》2014年第12期301-307,共7页Jaime B. Long Luisa Galdi Joseph G. Hentz John B. Leslie Paul M. Magtibay Rosanne M. C. Kho Jeffrey L. Cornella Javier F. Magrina 
Objectives: Current prophylactic interventions fail to completely eliminate postoperative nausea and vomiting (PONV) for a substantial number of patients. A new antiemetic (aprepitant) has been effective in preventing...
关键词：HYSTERECTOMY Postoperative NAUSEA and VOMITING APREPITANT 
Synthesis of the major isomers of Aprepitant and Fosaprepitant被引量：2
《Chinese Chemical Letters》2013年第12期1118-1122,共5页Wei-Li Wan Yun He Mei Guan Xiao-Long Li Xu Cheng Yong Wu 
fnancial support from Sichuan provincial science and technology support program (No. 2011SZ0014)
The synthesis of two isomers of Aprepitant （APT） and three isomers of Fosaprepitant （FPT）, crucial components for quality control in manufacturing, is described. Herein, three chiral centers in the isomers of Apre...
关键词：J Aprepitant and Fosaprepitant Major isomers Chemical synthesis 
Controlling Chemotherapy-Induced Nausea and Vomiting with Neurokinin-1 Receptor Antagonists in Patients on AC-Based Chemotherapy—Are We There Yet?
《Journal of Cancer Therapy》2012年第1期90-102,共13页Kevin Yap Cassandra Leong Alexandre Chan 
Chemotherapy-induced nausea and vomiting (CINV) are distressing side effects of chemotherapy. Neurokinin-1 receptor antagonists (NK1-RAs) have been incorporated in the contemporary management of CINV. However, clinica...
关键词：AC Anthracycline-Based CHEMOTHERAPY APREPITANT Breast Cancer CASOPITANT Chemotherapy-Induced Nausea Vomiting Neurokinin-1 Receptor ANTAGONISTS (NK1-RAs) 
Aprepitant使用评估
《嘉基藥訊》郭惠如 
Aprepitant有助于治疗急迫性尿失禁
《国外药讯》2007年第7期24-24,共1页罗娟（摘） 
美国的研究人员表示，选择性神经激肽-1受体拮抗剂Aprepitant（I），有治疗急迫性尿失禁的潜力。
关键词：急迫性尿失禁 治疗 神经激肽-1 受体拮抗剂 研究人员 
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