NITROIMIDAZOLE

作品数：9被引量：18H指数：3
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相关领域：化学工程医药卫生更多>>
相关作者：夏曦周成合更多>>
相关机构：中国农业大学西南大学更多>>
相关期刊：《Science China Chemistry》《Chinese Journal of Chemical Engineering》《Chemical Research in Chinese Universities》《Chinese Journal of Chemistry》更多>>
相关基金：国家自然科学基金重庆市自然科学基金中国博士后科学基金国家教育部博士点基金更多>>
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Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier
《Particuology》2024年第3期269-280,共12页Danping Wu Jiaying Zou Junyi Chen Yan Li Na Ma Wei Dai 
the National Natural Science Foundation of China(grant No.22178325).
Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are ...
关键词：ORNIDAZOLE METRONIDAZOLE Carbon spheres Sustained-release performance Biocompatibility 
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy被引量：2
《Acta Pharmaceutica Sinica B》2023年第1期298-314,共17页Yongchao Chu Yifan Luo Boyu Su Chao Li Qin Guo Yiwen Zhang Peixin Liu Hongyi Chen Zhenhao Zhao Zheng Zhou Yu Wang Chen Jiang Tao Sun 
supported by National Natural Science Funds of China(92059110/81872808,China);Development Fund for Shanghai Talents(2020090,China);FDU 2025-Excellence Program Fund(China);Program of Shanghai Academic Research Leader(18XD1400500,China);Project Supported by Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,China);ZJLab。
Metastasis accounts for 90%of breast cancer deaths,where the lethality could be attributed to the poor drug accumulation at the metastatic loci.The tolerance to chemotherapy induced by breast cancer stem cells(BCSCs)a...
关键词：Metastasis Breast cancer NEUTROPHIL HYPOXIA Cancer stem cell GLUTATHIONE Reactive oxygen species NITROIMIDAZOLE 
Determination and correlation solubility of 4-nitroimidazole in twelve pure solvents from 278.15 K to 323.15 K被引量：3
《Chinese Journal of Chemical Engineering》2020年第10期2634-2639,共6页Pengbao Lian Qiang Liu Lizhen Chen Cai Cao Jiaxiang Zhao Jianlong Wang 
supported by the Military Chemistry and Pyrotechnics National Defense Specialty Fund for North University of China。
In this paper,the solubility of 4-nitroimidazole in twelve pure solvents(toluene,benzene,1,4-dioxane,acetonitrile,ethyl acetate,acetone,GBL,ethanol,methanol,n-butanol,DMF and NMP)were determined by using the laser mon...
关键词：4-Nitroimidazole Laser monitoring system Solid–liquid equilibrium Solubility model Thermodynamic properties 
Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli被引量：6
《Science China Chemistry》2018年第5期557-568,共12页Guo-Biao Zhang Swetha Kameswari Maddili Vijai Kumar Reddy Tangadanchu Lavanya Gopala Wei-Wei Gao Gui-Xin Cai Cheng-He Zhou 
supported by the National Natural Science Foundation of China(21672173,21372186);Research Fund for International Young Scientists from International(Regional)Cooperation and Exchange Program of NSFC(81650110529);Chongqing Special Foundation for Postdoctoral Research Proposal(Xm2016039,Xm2017185);Program for Overseas Young Talents from State Administration of Foreign Experts Affairs,China(WQ2017XNDX047);the Doctoral Fund of Southwest University(SWU111075);the Research Funds for the Central Universities(XDJK2017B015)
A series of natural berberine-derived nitroimidazoles as novel antibacterial agents were designed, synthesized and characterized by nuclear magnetic resonance(NMR), infrared spectra(IR), and high resolution mass spect...
关键词：berberine nitroimidazole Escherichia coli DNA membrane permeabilization 
Synthesis, characterization and theoretical study of 2-azido-4-nitroimidazole-based energetic salts被引量：2
《Chinese Chemical Letters》2014年第3期438-440,共3页Ke-Hui Hou Cong-Ming Ma Zu-Liang Liu 
The 2-azido-4-nitroimidazole-based energetic salts were synthesized in a simple and straightforward manner. The structures of these new salts were determined by IR, 1H NMR and 13C NMR spectroscopy and elemental analys...
关键词：SynthesisEnergetic compoundsHeats of formation2-Azido-4-nitroimidazole 
Synthesis of 2-Azido-4-nitroimidazole and Its Derivatives for High-Energy Materials被引量：2
《Chinese Journal of Chemistry》2013年第12期1539-1545,共7页Kehui Hou Congming Ma Zuliang Liu 
2-Azido-4-nitroimidazole and its derivatives have been synthesized for energetic material applications. The synthesized compounds were fully characterized by 1H, 13C NMR spectroscopy and elemental analysis. Most of th...
关键词：organic chemistry SYNTHESIS 2-azido-4-nitroimidazole single crystal energetic materials 
Prediction of Enhancement Effect of Nitroimidazoles on Irradiation by Gene Expression Programming
《Chemical Research in Chinese Universities》2013年第3期519-525,共7页LONG Wei ZHANG Xiao-dong WANG Hao SHEN Xiu SI Hong-zong 
Supported by the National Natural Science Foundation of China（No.81202153）, the Research Fund for Youth Scholars of Union Medical College of China（No.2012D03）, the Research Fund for the Doctoral Program of Higher Education of China （No.20121106120042） and the Development Fund of Institute of Radiation Medicine, Chinese Academy of Medical Sciences （No.SF1227）.
A novel machine learning method, gene expression programming（GEP）, was employed to build quatitative structure-activity relationship（QSAR） models for predicting the enhancement effect of nitroimidazole compounds o...
关键词：NITROIMIDAZOLE Irradiation enhancement effect Gene expression programming 
Synthesis and Characterization of Some N-Aryl-4-nitroimidazoles as Potential Insensitive Energy Materials被引量：3
《Chinese Journal of Chemistry》2013年第2期243-246,共4页Kehui Hou Zuliang Liu 
N-Aryl derivatives of 4-nitroimidazole have been synthesized under CuI/TBAB catalytic system in excellent yields, using KOH as base in DMF solvent.
关键词：organic chemistry synthesis CuI-catalyzed N-ARYLATION 4-nitroimidazole 
[(99m)~Tc(CO)_3]^+ labeled histidine derivative containing 4-nitroimidazole:Synthesis,biodistribution as a tumor hypoxia imaging agent
《Nuclear Science and Techniques》2011年第2期105-110,共6页MEI Lei CHU Taiwei 
Supported by the National Natural Science Foundation of China(Grant No.20771011and21071010)
A novel histidine derivative containing 4-nitroimidazole,(S)-2-(4-((4-nitro-1H-imidazol-1-yl) methyl) benzamido)-3-(1H-imidazol-4-yl)propanoic acid (His-NI),was synthesized and labeled with [99mTc(CO)3(H2O)3]+.The tri...
关键词：硝基咪唑 衍生物 组氨酸 CO 肿瘤 合成 缺氧 显像剂 
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