LEUKEMIAS

作品数：12被引量：24H指数：3
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Noncanonical PI3Kγ signaling addiction is a therapeutic target in a subset of leukemias
《The Innovation》2024年第6期21-22,共2页Yu Zhang Qian Kong Yonglong Zhang 
supported by the National Natural Science Foundation of China(82472802 and 82073258);Natural Science Foundation of Shanghai(23ZR1448600).
Acute myeloid leukemia(AML)is a devastating disease with a median age of diagnosis of over 60 years.Thus,most AML patients are not eligible for intensive chemotherapy.Relapse remains common in patientswith AML despite...
关键词：THERAPEUTIC diagnosis Acute 
Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias
《World Journal of Meta-Analysis》2023年第5期181-195,共15页Ana Clara Carvalho Cardoso Brito Everton Oliveira Carneiro Ribeiro Fabrício Freire de Melo 
BACKGROUND Haploidentical hematopoietic stem cell transplantation(Haplo-HSCT)is often performed in children with hematologic malignancies.Faced with the gap in the literature regarding the approach to experiences rela...
关键词：HAPLOIDENTICAL Stem cell transplantation CHILDREN Cancer Treatment outcome PROGNOSIS 
Epidemiological and Disease Burden Profiles of Leukemias and Malignant Lymphomas: Overview and Trends in the Republic of Moldova and Worldwide
《International Journal of Clinical Medicine》2023年第2期79-95,共17页Vasile Musteata 
Introduction: Hematological malignancies (HM) are relatively frequent nosological entities within the structure of morbidity by malignant tumors, exhibiting a severe evolution, restrained prognosis and negative socio-...
关键词：Hematological Malignancies Epidemiological Patterns Incidence Mortality Disability-Adjusted Life-Years Disease Burden Management 
Overall results and prospects of the cancer risk assessment in the Urals population affected by chronic low dose-rate exposure
《Radiation Medicine and Protection》2022年第4期159-166,共8页Alexander Vasilyevich Akleyev Marina Olegovna Degteva Ludmila Yurievna Krestinina 
The paper presents the key milestones and outcomes of 65-year studies of the carcinogenic consequences of accidental radiation exposure of the population of the Ural region.The radioactive contamination of the Techa R...
关键词：Radio-epidemiological studies Techa river East Urals radioactive trace Malignant tumors LEUKEMIAS Dose-rate factor 
Mechanisms of resistance to FGFR1 inhibitors in FGFR1-driven leukemias and lymphomas:implications for optimized treatment被引量：3
《Cancer Drug Resistance》2021年第3期607-619,共13页John K.Cowell Tianxiang Hu 
This work was supported by a grant from the National Institutes of Health,CA076167。
Myeloid and lymphoid neoplasms with eosinophilia and FGFR1 rearrangements(MLN-eo FGFR1)disease is derived from a pluripotent hematopoietic stem cell and has a complex presentation with a myeloproliferative disorder wi...
关键词：MLN-eo FGFR1 LYMPHOMAS FGFR1 MUTATIONS PTEN PUMA mouse models 
DNA methylation markers in the diagnosis and prognosis of common leukemias被引量：1
《Signal Transduction and Targeted Therapy》2020年第1期2468-2477,共10页Hua Jiang Zhiying Ou Yingyi He Meixing Yu Shaoqing Wu Gen Li Jie Zhu Ru Zhang Jiayi Wang Lianghong Zheng Xiaohong Zhang Wenge Hao Liya He Xiaoqiong Gu Qingli Quan Edward Zhang Huiyan Luo Wei Wei Zhihuan Li Guangxi Zang Charlotte Zhang Tina Poon Daniel Zhang Ian Ziyar Run-ze Zhang Oulan Li Linhai Cheng Taylor Shimizu Xinping Cui Jian-kang Zhu Xin Sun Kang Zhang 
supported in part by the National Natural Science Foundation of China(Grant 81102248);Science and Technology Plan Projects of Guangdong(Grant 2014A020212695);Natural Science Foundation of Guangdong Province,Major Special Project of Guangzhou Science and Technology and Information Bureau(Grant 122400037)。
The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis,treatment selection,and prognosis prediction of patients.Using genome-wide methylation...
关键词：diagnosis PROGNOSIS ACUTE 
Identification and targeting of CD22ΔE12 as a molecular RNAi target to overcome drug resistance in high-risk B-lineage leukemias and lymphomas被引量：1
《Cancer Drug Resistance》2018年第1期30-47,共18页Fatih M.Uckun Sanjive Qazi 
The project described was supported by the DHHS grant R43CA177067(Uckun FM)from the National Cancer Institute.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.Uckun FM was also supported in part by DHHS grants P30CA014089,U01-CA-151837,R01CA-154471 and R21-CA-164098(Uckun FM)from the National Cancer Institute;by the V-Foundation,Nautica Triathlon as well as the Ronald McDonald House Charities of Southern California.
Aim:CD22ΔE12 as an oncogenic driver lesion in aggressive and drug-resistant B-precursor acute lymphoblastic leukemia(BPL)cells.The purpose of the present study was to identify the CD22ΔE12-specific signature transcr...
关键词：Cancer leukemia RNA interference nanomedicine personalized medicine driver lesion 
Leukemia stem cells： the root of chronic myeloid leukemia被引量：15
《Protein & Cell》2015年第6期403-412,共10页Hong Zhou 
We apologize to the scientists who made contributions to the field, but have not been cited due to the space limitations. This work was sup- ported in part by the National Natural Science Foundation of China （Grant Nos. 81270601, 81328016, and 81470306） and Leukemia Research Innovative Team of Zhejiang Province （2011 R50015）.
Chronic myeloid leukemia （CML） is a clonal myeloprolif- erative disorder characterized by a chromosome translocation that generates the Bcr-Abl oncogene en- coding a constitutive kinase activity. Despite remarkable ...
关键词：chronic myeloid leukemia （CML） leukemiastem cells （LSCs） tyrosine kinase inhibitors （TKIs） CaMKII-~ molecular switch 
Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias被引量：3
《Chinese Medical Journal》2014年第9期1645-1650,共6页Fang Hongbo Liu Jing Guo Dan Liu Peixiang Zhao Yongliang 
This study was supported by the National Basic Research Program of China （973 Program, No. 2013CB911000） and the National Nature Science Foundation of China （No. 30971602, 81272929）.Acknowledgements： We thank Dr. Chi Zhenfen for help with cell culture.
Background Both in vitro and in vivo data have demonstrated the TGFBI gene functions as a putative tumor suppressor and is frequently downregulated in human tumors of different histological types.The hypermethylation ...
关键词：TGFBI LEUKEMIA methylation-specific PCR HYPERMETHYLATION 
Immune Therapy Could Treat Leukemias, Autoimmune Diseases, and TransplantRejection
《当代外语研究》2006年第1期6-7,30,共3页Dennis Meredith 李鑫 
艾滋病毒之所以横行肆虐,原因之一就是它会摧毁免疫系统。研究人员成功地运用单株抗体(Monoclonal Antibody)来治疗老鼠的白血病,而相同的方法同样可应用于自体免疫疾病和一级器官移植排斥．这一成果不仅给白血病患者提供了新的治疗途径...
关键词：化学疗法 白血病 免疫疗法 自体免疫疾病 治疗途径 艾滋病毒 免疫系统 移植排斥 副作用 抗体 
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