The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone(PLD)in the form of controlled porosity osmotic pump tablets(CPOT)in order to keep t...
BACKGROUND Paliperidone palmitate is a once-monthly injectable,atypical antipsychotic.To our knowledge,there has been only one report of paliperidone palmitate-induced angioedema presenting with acute laryngeal edema ...
Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anx...
supported in part by the National Science Fund of China(81771450,81471358);Shanghai Health Bureau scientific research grant(201540029);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(20152530)
Background The impairment of social function is widespread in the patients with chronic schizophrenia, which seriously affects family, life and work conditions.Aims The main purpose of this study was to investigate th...
This study was supported by grants from the National Natural Science Foundation of China (No. 81471357) and Shanghai Natural Science Foundation (No. 13ZR1439300).
Background:Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an...
funded by National Natural Science Foundation of China (No.81673378)
The aim of this work was to prepare ascending release compression-coated(CC) tablets with paliperidone(PAL) using a simple manufacturing technique and short manufacturing process.The release behavior and mechanisms in...
Objective: To explore the different effects of paliperidone and risperidone therapy on blood lipid and Hcy metabolism as well as endocrine hormones in patients with schizophrenia. Methods: A total of 118 patients with...
Objective To explore the influence of demographic characteristics,psychiatric symptoms and medication on the adherence of long-acting injectable paliperidone palmitate(PP)treatment in schizophrenia patients.Methods In...
supported by the project of Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81221002);Rational Medication Application Patterns of Schizophrenia(BMU20140430) of Peking University Health Science Center
Dear editor, P-glycoprotein (P-gp, also known as ATP-binding cassette transport sub-family B member 1, ABCB1) is a potent ATP-dependent efflux pump for a wide variety of drugs. Although studies of its substrates are...
One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical applications.And another purpose was to investigate ...