supported by the National Natural Science Foundation of China(81130011,81370839,81521003);Guangdong Science Foundation(2014A030312014);Guangzhou Projects Grant(15020025);American Heart Association FTF(16990086);National Institutes of Health Grants(DK064005,DK091239,DK106049)
The hedgehog signaling cascade is an evolutionarily conserved pathway that regulates multiple aspects of embryonic development and plays a decisive role in tissue homeostasis. As the best studied member of three hedge...