CHANNELRHODOPSIN

作品数:6被引量:13H指数:2
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相关领域:医药卫生生物学更多>>
相关作者:竺可青柳浦青陈飞沈吟更多>>
相关机构:浙江大学武汉大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Journal of Otology》《中华眼底病杂志》更多>>
相关基金:国家自然科学基金更多>>
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新型光遗传学工具Channelrhodopsin-XXM2.0和PsCatCh2.0恢复视觉功能的可行性分析
《中华眼底病杂志》2020年第11期838-845,共8页陈飞 沈吟 
国家重点研发计划(2017YFE0103400)。
目的探讨新型光遗传学工具Channelrhodopsin-XXM2.0(XXM2.0)、Channelrhodopsin-PsCatCh2.0(PsCatCh2.0)的光敏感性及动力学特征,分析其是否可用于光遗传学视觉功能的恢复。方法通过分子生物学技术将XXM2.0和PsCatCh2.0的基因片段连接...
关键词:视觉  光遗传学 Channelrhodopsin-XXM2.0 Channelrhodopsin-PsCatCh2.0 
Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease被引量:7
《Neural Regeneration Research》2019年第12期2147-2155,共9页Ke-Wei Wang Xiao-Lin Ye Ting Huang Xi-Fei Yang Liang-Yu Zou 
supported by the National Natural Science Foundation of China,No.81171191(to LYZ);the Shenzhen Special Fund Project on Strategic Emerging Industry Development of China,No.JCYJ20160422170522075(to LYZ);the Shenzhen Healthcare Research Project of China,No.201601015(to LYZ)
Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, bu...
关键词:nerve REGENERATION Alzheimer's disease amyloid-β1-42 DENTATE GYRUS channelrhodopsin-2 GLUTAMATE receptors memory neuroinflammation novel object recognition immunohistochemistry western blot assay neural REGENERATION 
Optogenetics and synaptic plasticity被引量:2
《Acta Pharmacologica Sinica》2013年第11期1381-1385,共5页Yu-feng XIE 
The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing ...
关键词:synaptic plasticity OPTOGENETICS OPSIN CHANNELRHODOPSIN HALORHODOPSIN LTP LTD learning and memory 
Optical control after transfection of channelrhodopsin-2 recombinant adenovirus in visual cortical cells
《Neural Regeneration Research》2012年第16期1228-1233,共6页Junping Yao Wensheng Hou Hao Wang Hui Liu Chuanhuang Weng Zhengqin Yin 
sponsored by the National Natural Science Foundation of China (General Program),No.81070749,31070882,30970758;Key Project of Chongqing Science & Technology Commission,No. 2010AB5118
Channelrhodopsin-2 ectopically expressed in the retina can recover the response to blue light in genetically blind mice and rats, but is unable to restore visual function due to optic nerve or optic tract lesions. Lon...
关键词:channelrhodopsin-2 recombinant adenovirus visual cortex blue light action potentials neuralregene ration 
Histological and Physiological Investigation of Channelrhodopsin-2 and Halorhodopsin in the Dorsal Cochlear Nucleus
《Journal of Otology》2011年第1期10-19,共10页T. Shimano B. Fyk-Kolodziej M. Asako K. Tomoda S. Bledsoe Z.H. Pan S. Molitor A.G. Holt 
supported by Ralph Wilson Foundation(to A.G.H);Capita Foundation(to A.G.H)
We have delivered viral vectors containing either Chop2 fused with GFP, Channelrhodopsin-2 (ChR2), or Halorhodopsin (HaloR) fused with mCherry (to form light gated cation channels or chloride pumps, respectively...
关键词:cochlear nucleus channelrhodopsin-2 HALORHODOPSIN TRACER optical control 
光敏感通道(Channelrhodopsin-2)--神经回路功能和神经系统疾病研究的新工具被引量:4
《中国生物化学与分子生物学报》2010年第5期418-422,共5页柳浦青 竺可青 
国家自然科学基金资助项目(No.519100-N10797)~~
光敏感通道(channelrhodopsin-2,ChR2)是一种受光脉冲控制的具有7次跨膜结构的非选择性阳离子通道蛋白,自1991年从莱茵衣藻中发现后被许多实验室所关注.依据ChR2可以快速形成光电流,使细胞发生去极化反应的电生理特性,ChR2已被广泛应用...
关键词:光敏感通道 光基因技术 神经回路 神经系统疾病 
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