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Covalent multi-targeted radiopharmaceuticals for enhanced tumor theranostics: 《Science China Chemistry》2025年第4期1456-1467,共12页Yirui Guo Zhengzhong Lv Yuqi Zhang Zhongsheng Zhao Yurong Fan Yan Chen Miao Li Xingxiang Ren Yiming Feng Zhixin Han Hongyuan Wen Guohua Fan Ru Yang Haibin Shi; supported by the National Natural Science Foundation of China(T2325019,22077092);the Basic Research Program of Jiangsu(BK20243030);the Special Project of“Technological Innovation”Project of CNNC Medical Industry Co.Ltd.(ZHYLYB2021001);the Four“Batches"Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(2022XM19);the Open Project Program of the State Key Laboratory of Radiation Medicine and Protection(GZK12024016,GZK12023050,GZK12024013);a Project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.; Tumor-targeted radiopharmaceuticals have become an attractive modality for tumor diagnosis and treatment in clinics.However;their wide clinical applications are seriously impeded by poor tumor targeting;rapid systemic...; 关键词：covalent targeted radiopharmaceuticals sulfenated protein nuclear imaging lung cancer THERANOSTICS

Advances in radiopharmaceuticals for precision medicine:A global and Chinese perspective: 《LabMed Discovery》2024年第2期1-9,共9页Qing-qing Huang Gang Huang; supported by the construction project of Shanghai Key Laboratory of Molecular Imaging of China(No.18DZ2260400);the research grants from the National Natural Science Foundation of China(No.82127807);the National Key Research and Development Program of China(No.2020YFA0909000).; Radiopharmaceuticals have become indispensable tools in precision medicine,revolutionizing diagnostic imaging and targeted therapeutic strategies.This manuscript provides an overview of advancements globally and in Ch...; 关键词：RADIOPHARMACEUTICAL Nuclear medicine Diagnostic imaging Therapeutic application Precision medicine

Qualitative and quantitative imaging of alpha‐emitting radiopharmaceuticals: 《iRADIOLOGY》2024年第4期396-411,共16页Lan Wang Jingjing Lou Xuecen Cao Lina Jia Shuai Xue Xingdang Liu Lan Zhang Xiao Li; Pudong Hospital,Fudan University,College Project,Grant/Award Numbers:YJYJRC202108,YJYJRC202101,Zdzk2020‐14;Pudong New Area Clinical Characteristic Discipline Project,Grant/Award Number:PWYts2021‐01;National Natural Science Foundation of China,Grant/Award Number:82272042;Clinical research program of Health Industry of Shanghai Municipal Commission of Health,Grant/Award Number:202150002;Shanghai Science and Technology Commission Project:Molecular imaging study on mild cognitive impairment,Grant/Award Number:17411950102;National Key Research and Development Plan Digital Diagnosis and Treatment Equipment Research and Development Project:Research and Practice of PET‐CT Comprehensive Evaluation System and Training System,Grant/Award Number:2017YFC0113300。; Targeted alpha(α)therapy(TAT)is an emerging therapeutic strategy for cancer treatment.To evaluate the safety and efficacy of targetedα‐therapy,the biodistribution and internal radiation dose ofα‐emitting radionuc...; 关键词：alpha‐emitting radionuclide qualitative imaging quantitative imaging targeted alpha therapy

Embracing artificial intelligence design for better radiopharmaceuticals: 《iRADIOLOGY》2024年第4期412-416,共5页Jinping Tao Xiangxing Kong Zhi Yang Hua Zhu; Capital's Funds for Health Improvement and Research,Grant/Award Numbers:2022‐2Z‐2154,2022‐2Z‐2155;Youth talent support program,Grant/Award Number:A002863。; 1|INTRODUCTION Cancer has emerged as a significant threat to human life,and its incidence and mortality are increasing rapidly.As clinicians increasingly seek to noninvasively investigate tumor phenotypes and evaluate...; 关键词：artificial intelligence RADIOPHARMACEUTICALS nuclear medicine

Inspired by novel radiopharmaceuticals:Rush hour of nuclear medicine被引量：1: 《Chinese Journal of Cancer Research》2023年第5期470-482,共13页Yang Liu Ya-nan Ren Yan Cui Song Liu Zhi Yang Hua Zhu Nan Li; Nuclear medicine plays an irreplaceable role in the diagnosis and treatment of tumors.Radiopharmaceuticals are important components of nuclear medicine.Among the radiopharmaceuticals approved by the Food and Drug Admi...; 关键词：Nuclear medicine RADIOPHARMACEUTICALS NEOPLASMS

Clinical applications of fibroblast activation proteintargeted theranostics in oncologic and nononcologic disease:Current status and future directions被引量：1: 《iRADIOLOGY》2023年第4期340-361,共22页Hao Fu Wei Guo Jingxiong Huang Hua Wu Haojun Chen; Key Scientific Research Program for Young Scholars in Fujian,Grant/Award Number:2021ZQNZD016;Fujian Natural Science Foundation for Distinguished Young Scholars,Grant/Award Number:2022D005;Medical and Health Guidance Projects of Xiamen,Grant/Award Numbers:3502Z20209269,3502Z20224ZD1001;National Natural Science Foundation of China,Grant/Award Numbers:82071961,82102094;Fujian Natural Science Foundation for Youth Innovation,Grant/Award Number:2022J05314;Fujian Research and Training Grants for Young and Middle-Aged Leaders in Healthcare。; Quinoline-based fibroblast activation protein(FAP)inhibitor(FAPI)-based positron emission tomography(PET)imaging and radioligand therapy(RLT)are being investigated for use in a wide variety of diseases,and recent resu...; 关键词：FAPI-PET FAP-targeted radioligand therapy FAP-targeted theranostics fibroblast activation protein RADIOPHARMACEUTICALS

Application of Radiopharmaceuticals in Targeted Tumor Therapies: 《IMP & HIRFL Annual Report》2022年第1期167-168,共2页Zhang Taotao Zhang Hong Li Qiang Di Cuixia; National Key Research and Development Plan of Ministry of Science and Technology(2018YFE0205100);Joint Key Project of National Natural Science Foundation of China(U1632270);National Natural Science Foundation of China(11675234)。; Radiopharmaceutical therapy uses tumor-targeting carriers to deliver cytotoxic radioactivity to tumor tissues,selectively killing tumor cells,and thus producing minimal toxic and side e ects on surrounding healthy tis...; 关键词：TUMOR THERAPY CLINICAL

Recent progress of astatine-211 in endoradiotherapy:Great advances from fundamental properties to targeted radiopharmaceuticals被引量：3: 《Chinese Chemical Letters》2022年第7期3325-3338,共14页Feize Li Yuanyou Yang Jiali Liao Ning Liu; the financial supports from the National Natural Science Foundation of China(No.22006105);the China Postdoctoral Science Foundation(No.2020M683309);the Fundamental Research Funds for the Central Universities。; Astatine-211(^(211)At,t_(1/2)=7.21 h)emitting twoαparticles with energies of 5.87 and 7.45 MeV,can lead to a high linear energy transfer(LET=98.84 ke V/μm)and short tissue range(50~90μm).Since the 1950s,^(211)At ha...; 关键词：Radionuclides Astatine-211 Target-alpha therapy RADIOPHARMACEUTICALS

Natural product-based radiopharmaceuticals:Focus on curcumin and its analogs,flavonoids,and marine peptides: 《Journal of Pharmaceutical Analysis》2022年第3期380-393,共14页Hendris Wongso; Natural products provide a bountiful supply of pharmacologically relevant precursors for the development of various drug-related molecules,including radiopharmaceuticals.However,current knowledge regarding the importa...; 关键词：Natural products RADIOPHARMACEUTICALS RADIOLABELING CURCUMIN FLAVONOIDS Marine peptides

The application of FAPI-targeted theranostics in pancreatic cancer:a narrative review: 《Journal of Pancreatology》2022年第2期78-86,共9页Meixi Liu Marcus Hacker Li Huo Xiang Li; This work was in part supported by the National Natural Science Foundation of China(No.82071967);CAMS Innovation Fund for Medical Science(No.CIFMS-2021-I2M-1-025);National Key Research and Development Program of China(No.2016YFC0901500);CAMS Fund for Rare Diseases Research(No.2016ZX310174-4);Tsinghua university and PUMCH Joint Fund(No.PTQH201906006).; Pancreatic cancer is one of the most lethal malignancies in the world.Cancer-associated fibroblasts are one of the main components of tumor microenvironment in pancreatic cancer and play an essential role in tumor pro...; 关键词：Diagnostic imaging Fibroblast activation protein Fibroblast activation protein inhibitor Pancreatic cancer RADIOPHARMACEUTICALS THERANOSTICS

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