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Acknowledgments We thank Xueliang Zhu for discussion, Shiyi Guo, Di An, Ruining Liu, Long Miao, and Chuanmao Zhang for technical assistance, and Tso-Pang Yao and Steven Y Cheng for reagents. This work was supported by grants from the National Basic Research Program of China (2012CB945002) and the National Natural Science Foundation of China (31130015, 31271437, and 31371382).
Cilia are hair-like organelles extending from the cell surface with important sensory and motility functions. Ciliary defects can result in a wide range of human diseases known as ciliopathies. However, the molecular ...
We thank Chuanmao Zhang, Xiaoyan Zhang and Jingyan Fu for TPX-2 antibody and NEDD1 plasmids; Masatoshi Takeichi and Wenxiang Meng for the ct-tubulin-pCAsalGFP plasmid. This work was supported by the National Natural Science Foundation of China (30971433, 31171283) and the National Basic Research Program of China (973 Program; 2010CB833705).
Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division. Spindle integrity is largely dependent on the centrosome and the microtubule network. Centrosome protein Cep57 can...
This work was supported by National Natural Science Foundation of China (30671070 and 30771107), Ministry of Science and Technology of China (2007CB914500), Ministry of Education of China (NCET-06-0530), and Natural Science Foundation of Zhejiang Province, China (R205291, Y206103, and 2007R10G2010103).
Cytokinesis is the process by which a single cell divides into two physically distinct daughter cells; however, the molecular details of this fundamental process remain largely unknown . In animal cells, cytokinesis u...