CHLORAMBUCIL

作品数：7被引量：2H指数：1
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相关领域：医药卫生更多>>
相关作者：李功更多>>
相关机构：北京大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Journal of Chinese Pharmaceutical Sciences》《Journal of Biophysical Chemistry》《Chinese Journal of Chemistry》更多>>
相关基金：国家自然科学基金更多>>
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pH-triggered dynamic erosive small molecule chlorambucil nano-prodrugs mediate robust oral chemotherapy
《Asian Journal of Pharmaceutical Sciences》2023年第4期142-152,共11页Xin Liu Zhexiang Wang Xiaodie Ren Xinyang Chen Jinjin Tao Yuanhui Guan Xuefeng Yang Rupei Tang Guoqing Yan 
supported by the Anhui Engineering Technology Research Center of Biochemical Pharmaceutical(Bengbu Medical College);the National Natural Science Foundation of China(No.51803001);the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003,KJ2018A0006 and KJ2019A0015);the Academic and Technology Introduction Project of Anhui University(AU02303203).
Currently,the dynamic erosive small molecule nano-prodrug is of great demand for oral chemotherapy,owing to its precise structure,high drug loading and improved oral bioavailability via overcoming various physiologic ...
关键词：Nano-prodrugs pH sensitivity Size transition Oral chemotherapy 
Intracellular enzyme-activatable prodrug for real-time monitoring of chlorambucil delivery and imaging被引量：2
《Chinese Chemical Letters》2017年第6期1345-1351,共7页Meng Ni Wen-Jun Zeng Xin Xie Ze-Lin Chen Hao Wu Chang-Min Yu Bo-Wen Li 
financial support by the Science and Technology Planning Project of Guangzhou(No.201607020015);the Science and Technology Planning Project of Guangdong Province(No.2014A010105009)
Carboxylesterase,a necessary enzyme in various mammalian cells,has been employed in various biological applications.Herein,we designed and synthesized a novel carboxylesterase-based prodrug,which can realize simultane...
关键词：Prodrug Carboxylesterase Chlorambucil Fluorescent imaging Liposomes 
Improvement of Stability and Anticancer Activity of ChlorambuciI-Tetrapeptide Conjugate Vesicles
《Chinese Journal of Chemistry》2016年第6期609-616,共8页Wei Zhang Wenjun Zhu Ruiyu He Shuo Fang Yemin Zhang Chen Yao Muhammad Ismail Xinsong Li 
Chlorambucil is a classic nitrogen mustard drug that has been used in the treatment of cancers. It may induce neutropenia, thrombocytopenia and other side effects because of its short lifetime and off-target effect. I...
关键词：chlorambucil-tetrapeptide conjugate SELF-ASSEMBLY vesicles anticancer activity 
A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles
《Nano Research》2016年第2期537-548,共12页Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor 
Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to r...
关键词：chronic lymphocytic leukemia immune targeted nanoparticles TREATMENT xenograft model 
Chlorambucil Encapsulation into PLGA Nanoparticles and Cytotoxic Effects in Breast Cancer Cell
《Journal of Biophysical Chemistry》2015年第1期1-13,共13页Diego J. S. Dias Graziella A. Joanitti Ricardo B. Azevedo Luciano P. Silva Claure N. Lunardi Anderson J. Gomes 
The present work aimed to develop and evaluate a colloidal system composed of poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) associated with chlorambucil (CHB) and its effects on cancer cells. The nanoparti...
关键词：CHLORAMBUCIL PLGA NANOPARTICLES CANCER MCF-7 
Modification of the alkylating agent chlorambucil with spiropiperazinium salts
《Journal of Chinese Pharmaceutical Sciences》2010年第5期346-352,共7页李功 孙崎 崔景荣 李润涛 
National Natural Science Foundation of China (Grant No.20472008);Fund for Young Teachers of School of Pharmaceutical Sciences,Peking University
In order to improve the antitumor activity and reduce the toxicity of the alkylating agent chlorambucil, a series of spiropiperazinium salts of chlorambucil （8） were designed and synthesized. It was found that compo...
关键词：CHLORAMBUCIL Antitumor activity Spiropiperazinium SAR 
Synthesis of 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide-chlorambucil Conjugates
《Chinese Chemical Letters》2000年第10期879-882,共4页Yu Fei SONG (Institute of Molecular Science, Shanxi University, Taiyuan 030006) 
Provincial Natural Foundation of Shanxi Province.
This paper reports a continous study of the use of short chain peptides as carriers of a potential antitumor agents: 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). In an effort to carry out anti-cancer drug...
关键词：2.6-dimethoxyhydroquinone-3-mercaptoacetic acid CHLORAMBUCIL PEPTIDE 
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