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INACTIVATED: 作品数：113被引量：207H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘芳任爱国何志义马俊荣徐应军更多>>; 相关机构：华北煤炭医学院中国预防医学科学院中国医科大学附属第一医院华中农业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划重庆市自然科学基金国家重点基础研究发展计划更多>>

Immunosuppressive therapy selectively modulates B-cell responses in patients with rheumatic and musculoskeletal diseases receiving the inactivated COVID-19 vaccine: 《Rheumatology & Autoimmunity》2023年第2期78-89,共12页Rui Li Ruru Guo Jia Li Bing Zheng Ronghao Xu Xiaoyue Jiang Yingying Chen Guo Tang Qianqian Li Yixuan Li Jiaqi Feng Xiaoxiang Chen Ying Wang Shuang Ye Fang Du Liangjing Lu Jun Deng; National Natural Science Foundation of China,Grant/Award Numbers:82271784,81974251,82071816;National Key Research and Development Program of China,Grant/Award Number:2017YFC0909002。; Background:Immunosuppressive medication reduces the immunogenicity of the coronavirus disease 2019(COVID-19)vaccines in patients with rheumatic and musculoskeletal diseases(RMDs).However,the underlying mechanism remai...; 关键词：COVID-19 vaccination humoral and cellular responses immunosuppressive medication rheumatic and musculoskeletal diseases

Role of inactivated SARS-CoV-2 vaccine induced T cell responses in ameliorating COVID-19 severity被引量：1: 《Virologica Sinica》2023年第2期324-326,共3页Hongming Huang Jia Liu; supported by grants from the National Natural Science Foundation of China(82172256,92169105,81861138044,and M-0060);the National Scientific and Technological Major Project of China(2017ZX10202203);the Sino-German Virtual Institute for Viral Immunology.; The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine is one of the most effective weapons to fight the coronavirus disease 2019(COVID-19)pandemic(Lazarus et al.,2022).Among all SARS-CoV-2 vaccines ge...; 关键词：VACCINE SEVERITY ACUTE

Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight被引量：1: 《Genes & Diseases》2023年第2期608-617,共10页Qian Zhu Yingzhi Zhang Juan Kang Zhiwei Chen Mingli Peng Min Chen Gaoli Zhang Dejuan Xiang Shuang Xiao Hu Li Ying Mei Jie Yang Xiaoya Qi Dachuan Cai Hong Ren; supported by the National Science and Technology Major Project of China(No.2017ZX10202203-007,No.2017ZX10202203-008,and No.2018ZX10302206-003);a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine:hepatic fibrosis.We also acknowledge the support of the National Natural Science Foundation of China(No.81772198);the Natural Science Foundation of Chongqing,China(No.cstc2020jcyj-msxmX0389);General Project of Chongqing Natural Science Foundation(No.cstc2020jcyj-msxmX0015).; Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population.However,limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these vaccines....; 关键词：COVID-19 Immune response Inactivated vaccine OBESITY OVERWEIGHT

An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV被引量：2: 《Virologica Sinica》2023年第2期244-256,共13页Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang; funded by the National Key Research and Development Program of China(grant No.2021YFC2600202);the National Natural Science Foundation of China(grant numbers 31872487).; Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent ne...; 关键词：SARS-CoV-2 Vaccine RBD Chimeric expression RABV

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection被引量：3: 《Cell Research》2023年第3期258-261,共4页Bo Gao Liheng He Yujie Bao Yingying Chen Guanzhu Lu Yu Zhang Yingjie Xu Bing Su Jie Xu Ying Wang Leng-Siew Yeap; This work was supported by funds from the National Key R&D Program of China(2021YFA1301400 to B.S.,Y.X.,L.-S.Y.,and 2021YFC2301500 to Y.W.);the National Natural Science Foundation of China(31722020 to L.-S.Y.,31930035,91942311 and 32061143028 to B.S.);Shanghai Science and Technology Commission(20410714000,20JC410100 and 22JC1402600 to B.S.).; Dear Editor,Since the emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019,the virus has continued to evolve resulting in new waves of infection and immune escape in the vaccinated populatio...; 关键词：VACCINATION ANTIBODIES INFECTION

Impact of inactivated COVID-19 vaccines on viral shedding in B.1.617.2(Delta)variant-infected patients被引量：1: 《Science China(Life Sciences)》2022年第12期2556-2559,共4页Zhiliang Hu Yi Yin Kai Wang Miaomiao Xu Chengyuan Ding Yan Song Changhua Yi Junwei Li Yongxiang Yi Zhihang Peng; supported by the National Natural Science Foundation of China(82073673);the National Science and Technology Major Project of China(2018ZX10715002-004-002,2018ZX10713001-001);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Key Research and Development Program of Department of Health of Jiangsu(ZDB2020036);Project of Nanjing Infectious Disease Clinical Medical Center Construction(NA2021062071)。; Dear Editor,The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2)has waged a global pandemic. As of April 15, 2022, more than 500 million cases of COVID-19 had ...; 关键词：vaccines ACUTE

Receipt of inactivated COVID-19 vaccine had no adverse influence on embryo implantation,clinical pregnancy and miscarriage in early pregnancy被引量：2: 《Science China(Life Sciences)》2022年第11期2332-2334,共3页Yapeng Wang Xiulian Ren Zhongwei Wang Xue Feng Ming Li Ping Liu; the National Natural Science Foundation of China for Young Scholars(81601275,31801251);the National Natural Science Foundation of China(82071721)。; Dear Editor,Pregnant women are at high risk of COVID-19 infection.During pregnancy,COVID-19 infection increases the risk of preterm delivery and the probability of intensive care unit care for the parturient and neona...; 关键词：pregnancy VACCINE

Humoral response to inactivated SARS-CoV-2 vaccines in patients on sirolimus alone被引量：1: 《Science China(Life Sciences)》2022年第10期2118-2120,共3页Chongsheng Cheng Yani Wang Danjing Hu Wangji Zhou Chunlong Liu Xinlun Tian Hongbing Zhang Ying-Chun Xu Kai-Feng Xu; supported by the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS2021-I2M-1-003);the National Natural Science Foundation of China(U20A20341);the Beijing Science and Technology Plan(Z211100002521024)。; Dear Editor,Sirolimus,a prototype of mammalian target of rapamycin(m TOR)inhibitor,was approved by the FDA as an immunosuppressant in combination with cyclosporine and corticosteroids for prophylaxis of organ rejectio...; 关键词：VACCINE vaccines

Impact of various vaccine boosters on neutralization against omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine被引量：3: 《Science Bulletin》2022年第13期1326-1330,M0003,共6页Qingrui Huang Jiawei Zeng Qingyun Lang Feng Gao Dejun Liu Siyu Tian Rui Shi Ling Luo Hao Wang Liping Hu Linrui Jiang Yawei Liu Kailiang Li Yunbo Wu Junjie Xu Wenxi Jiang Ning Guo Zhihai Chen Xiaohua Hao Ronghua Jin Jinghua Yan Yufa Sun; supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29040201);the National Natural Science Foundation of China(NSFC)(81901680)。; SARS-CoV-2 Omicron变异株已在全球范围内广泛传播.包括中国在内的许多国家广泛接种了SARS-CoV-2灭活疫苗(IAV)、重组蛋白疫苗(PRV)和腺病毒载体疫苗(Ad V),以达到群体免疫效果.该研究系统评价了完成不同疫苗全程接种后以及接种不同疫...; 关键词：灭活疫苗不同疫苗免疫接种初次免疫 PRV 系统性评价群体免疫中和活性

Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human A CE2-transgenic mice: 《Signal Transduction and Targeted Therapy》2022年第1期310-321,共12页Zhenfei Bi Weiqi Hong Haiying Que Cai He Wenyan Ren Jingyun Yang Tianqi Lu Li Chen Shuaiyao Lu Xiaozhong Peng Xiawei Wei; This work is supported by the National Natural Science Foundation Regional Innovation and Development(No.U19A2003);National Major Scientific and Technological Special Project for"Significant New Drugs Development"(No.2018ZX09733001);the Excellent Youth Foundation of Sichuan Scientific Committee Grant in China(No.2019JDJQ008);the Development Program of China(No.2016YFA0201402).; The development of animal models for COVID-19 is essential for basic research and drug/vaccine screening.Previously reported COVID-19 animal models need to be established under a high biosafety level condition for the...; 关键词：DISTRESS LUNG ROUTINE

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