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Inactivated SARS-CoV-2 booster vaccine enhanced immune responses in patients with chronic liver diseases
《Virologica Sinica》2023年第5期723-734,共12页Yongmei Liu Jianhua Lu Haoting Zhan Wenfang Yuan Xiaomeng Li Haiyan Kang Haolong Li Yongliang Chen Linlin Cheng Xingli Sun Haojie Zheng Wei Wang Erhei Dai Yongzhe Li 
This work was supported by the Beijing Natural Science Foundation(M23008);the National Key Research and Development Program of China(2018YFE0207300);Beijing Municipal Science&Technology Commission(Z211100002521021);the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-124);Key Research and Development Plan of Hebei Province,Special Health Innovation Project(22377744D).
Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Th...
关键词：Chronic liver disease(CLD) SARS-CoV-2 inactivated vaccines Booster vaccination Antibody response Immune response 
Delta(B.1.617.2)inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques
《Virologica Sinica》2023年第4期627-630,共4页Yanjun Zhang Haiyan Mao Ju Li Jianhua Li Chen Huang Jiaxuan Li Minglei Chu Fengbo Xue Linhui Wang Zhongbiao Fang Zhen Wang Jinan Wu Keda Chen 
supported by the Science and Technology Program of Zhejiang Province (#2022C03017);Key Research and Development Program of Zhejiang Province (#2021C03044);Major Health Science and Technology Projects of Zhejiang Province (#WKJ-ZJ-2105);National Key R&D Program of China (#2021YFC2301200).
Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has resulted in 763 million cases and over 6 million deaths as of April 2023.Given the high prevalence and widespread distribution of coronaviruses,the geneti...
关键词：ANTIBODIES VACCINE 
Role of inactivated SARS-CoV-2 vaccine induced T cell responses in ameliorating COVID-19 severity被引量：1
《Virologica Sinica》2023年第2期324-326,共3页Hongming Huang Jia Liu 
supported by grants from the National Natural Science Foundation of China(82172256,92169105,81861138044,and M-0060);the National Scientific and Technological Major Project of China(2017ZX10202203);the Sino-German Virtual Institute for Viral Immunology.
The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine is one of the most effective weapons to fight the coronavirus disease 2019(COVID-19)pandemic(Lazarus et al.,2022).Among all SARS-CoV-2 vaccines ge...
关键词：VACCINE SEVERITY ACUTE 
An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV被引量：2
《Virologica Sinica》2023年第2期244-256,共13页Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang 
funded by the National Key Research and Development Program of China(grant No.2021YFC2600202);the National Natural Science Foundation of China(grant numbers 31872487).
Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent ne...
关键词：SARS-CoV-2 Vaccine RBD Chimeric expression RABV 
Protection from infection or disease? Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines
《Virologica Sinica》2022年第6期783-785,共3页Anthony T.Tan Joey Ming Er Lim Antonio Bertoletti 
supported by the Singapore Ministry of Health’s National Medical Research Council MOH-000019(MOH-Sta R17Nov-0001) grant
How do we measure vaccine efficacy? The strictest but also easiest parameter to determine vaccine efficacy is its ability to block infection.Indeed, if a vaccine is able to block infection, this necessarily follows th...
关键词：VACCINE INFECTION vaccines 
Anti-SARS-CoV-2 IgY Isolated from Egg Yolks of Hens Immunized with Inactivated SARS-CoV-2 for Immunoprophylaxis of COVID-19被引量：2
《Virologica Sinica》2021年第5期1080-1082,共3页Haiyan Shen Yanxing Cai Huan Zhang Jie Wu Lin Ye Penghui Yang Xiaojun Lin Shibo Jiang Ming Liao 
supported by grants from the Key Research and Development Project of Guangdong Province(202020012624900001);the National Natural Science Foundation of China(31830097,31802174 and 82041025);the Key Research and Development Project of Guangdong Province(2020B1111320001);the Special fund for the Scientific innovation strategy-construction ofhigh level Academyof Agriculture Science-Prominent Talents(R2020PY-JC001)。
Dear Editor,In the absence of vaccine,the mounting second wave of COVID-19 infections worldwide calls for the rapid development of human neutralizing antibodies to prevent and treat COVID-19(Lee et al.2020).Considerin...
关键词：MOUNT neutral COV 
From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease(HFMD)被引量：18
《Virologica Sinica》2021年第2期167-175,共9页Xiangchuan He Miaomiao Zhang Chen Zhao Peiyong Zheng Xiaoyan Zhang Jianqing Xu 
sponsored by the National Natural Science Foundation of China(81672018);the National 13th Five-Year Grand Program on Key Infectious Disease Control(2017ZX10202102);the 13th Five-Year National Science and Technology Major Project for infectious Diseases(2017ZX10305501-002);Shanghai Pujiang Program(19PJ1409100);the Technology Service Platform for Detecting High level Biological Safety Pathogenic Microorganism Supported by Shanghai Science and Technology Commission(18DZ2293000)。
Hand,foot,and mouth disease(HFMD)recently emerged as a global public threat.The licensure of inactivated enterovirus A71(EV-A71)vaccine was the first step in using a vaccine to control HFMD.New challenges arise from c...
关键词：Hand foot and mouth disease(HFMD) Inactivated whole virus vaccine Virus-like particles Multivalent vaccines Chimeric vaccines 
Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine被引量：17
《Virologica Sinica》2018年第2期201-204,共4页Fan Luo Fan-Lu Liao Hui Wang Hong-Bin Tang Zhan-Qiu Yang Wei Hou 
supported by the Chinese Medicine Foundation and Opening Foundation of State Key Laboratory of Virology,Wuhan University (No.2016KF010)
In 2003,severe acute respiratory syndrome coronavirus（SARS-CoV）emerged in Guangdong Province,China,infected more than 8000 individuals,and resulted in a 10%mortality rate（Rota et al.2003）.Later,in 2012,a novel CoV...
关键词：SARS-COV 感染 猕猴 活性 免疫 疫苗 评估 抗体 
A Semi-quantitative Serological Method to Assess the Potency of Inactivated Rabies Vaccine for Veterinary Use被引量：1
《Virologica Sinica》2012年第4期259-264,共6页Ye Liu Shoufeng Zhang Fei Zhang Rongliang Hu 
the China National"863"Program(Approval No.2011AA10A212);Special Fund for Agro-Scientific Research in the Public Interest(ApprovalNo.201203056)
Potency is one of the most important indexes of inactivated vaccines.A number of methods have been established to assay the potency,of which the NIH test and single-dose mouse protection test are the "prescribed metho...
关键词：RABIES Inactivated vaccine Potency assay Semi-quantitative method 
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