Objective : To investigate the effect of Radix Paeoniae Rubra (RPR) on the expression of heme oxygenase ( HO- 1 ) and induced nitric oxide synthase ( iNOS ) in endotoxin- induced acute lung injury in rats and i...
theNationalNaturalScienceFoundationofChina (No .39970 719;30 170 919)
Objective: To investigate the expression of lipopolysaccharide binding protein (LBP) and its gene in rats with endotoxemia and explore the role of LBP in the response of host to endotoxin. Methods: Thirty Wistar rats ...
Objective: To construct the multi probe ribonuclease protection assay (RPA) template set to be used for detecting expression patterns of MD 2, TLR4, CD14 mRNAs in human peripheral blood mononuclear cells. Methods: The...
NationalNatureScienceFundGrant (No .395 0 0 15 0 ) ;OutstandingTalentFundGrantof NationalNatureScienceFundCommittee (No .3972 5 0 2 9)
Objective: To test the hypothesis that acute phase reactants, such as alpha 1-antitrypsin and alpha 1-acid glycoprotein, could protect mammalian cells from further damage. Methods: Human dermal fibroblasts (5×10 4) w...
Objective:: To evaluate activation of P38 mitogen-activated protein kinase (P38MAPK) in alveolar macrophage (AM), release of TNFα and NO from cells, and their relationship following lipopolysacchride (LPS) stimulatio...
To observe effect of endothelin-1 (ET-1) on hepatic damage induced by endotoxin. Methods: A total of 90 rats were randomly divided into control group (group C), endotoxin treated group (group LPS) and endotoxin plus E...
Objective: To observe tissue distribution and cell localization of TNF α mRNA and its protein and study their role in the pathogenesis of liver injury in burn rats. Methods: An animal model of rats subjected to 2...