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Asthma is a chronic respiratory disease,and clinically,asthma exacerbations remain difficult to treat.The disease is caused by combinations of and interactions between genetic and environmental factors.Genomic and gen...
supported by grants from the Thirteen-Fifth Mega-Scientific Project on“Prevention and Treatment of AIDS,Viral Hepatitis and Other Infectious Diseases”(No.2017ZX10201301-007-002);the National Natural Science Foundation of China(No.82072233).
Objective Current commercially available immunological tests cannot be used for discriminating active tuberculosis(TB)from latent TB infection.To evaluate the value of biomarker candidates in the diagnosis of active T...
This study was supported by grants from the National Natural Science Foundation of China(Nos.81773726,82073907,and 82073842);the Shanghai Science and Technology Innovation Action Plan(Nos.20ZR1470100,18431900800,and 20S11902700);the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program,China(No.2018ZX09711002-003-015).
The excess deposition of underlying extracellular matrix (ECM) in adipose tissue is defined as adipose tissue fibrosis that is a major contributor to metabolic disorder such as obesity and type 2 diabetes. Anti-fibros...
In this editorial,the roles of orosomucoid(ORM)in the diagnoses and follow-up assessments of both nonneoplastic diseases and liver tumors are discussed with respect to the publication by Zhu et al presented in the pre...
The genetic variants of orosomucoid-like protein 3(ORMDL3)gene are associated with highly significant increases in the number of human rhinovirus(HRV)-induced wheezing episodes in children.Recent investigations have b...
Supported by Medicine and Health Science and Technology Plan Projects of Zhejiang Province,No.2018KY569;Zhejiang Provincial Natural Science Foundation of China,No.LY17H030002
BACKGROUND Liver cancer has a high mortality and morbidity rate throughout the world.In clinical practice,the prognosis of liver cancer patients is poor,and the complex reasons contribute to treatment failures,includi...
Gender differences in fatigue,manifesting as female more prone to feel exhausted with lower muscle endurance,still remains unclear mechanism.Here,we investigated whether orosomucoid,an endogenous anti-fatigue protein ...
Background: Porcine adipose tissue expresses orosomucoid(ORM1) mRNA, a protein with anti-inflammatory and immunomodulatory properties. Previous research has demonstrated that porcine ORM1 can reduce insulin stimula...
Supported by Natural Science Foundation of China(Effect of Gubenfangxiao Decoction on the Expression of Asthma Susceptibility Gene ORMDL3 and ADAM33 and its Signaling pathway,No.81173209)
OBJECTIVE: To investigate the effect of Gubenfangxiao decoction (GBFXD) on respiratory-syncytial-virus (RSV) -induced asthma and the expression of asthma susceptibility gene, orosomucoid 1-1ike protein 3 (ORMDL3...