NANODEVICE

作品数：25被引量：23H指数：3
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相关机构：密歇根州立大学更多>>
相关期刊：《National Science Review》《Science China(Information Sciences)》《International Journal of Extreme Manufacturing》《Science China Chemistry》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划更多>>
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  • 学科=医药卫生—临床医学x
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An epH-driven DNA nanodevice for impeding metastasis in vivo by selectively blocking cell signaling
《National Science Review》2025年第3期255-266,共12页Kun Yuan Hong-Min Meng Hongzhi Sun Lingbo Qu Zhaohui Li Weihong Tan 
supported by the Natural Science Foundation of Henan(232300421021 and 242300421121);the National Natural Science Foundation of China(22374136,22274143);Henan Fundamental Research Leading Talent,and the National Key Research and Development Program(2023YFF0714402 and 2023YFF0714400).
Invasion and metastasis dominate tumor progression,causing a substantial proportion of cancer-related deaths.However,the efficacy of current antimetastatic treatments is hampered by the dearth of targeted therapeutics...
关键词：antimetastatic therapy cellular signaling blockade DNA nanodevice extracellular pH tailored bioregulation 
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment
《Acta Pharmaceutica Sinica B》2024年第8期3777-3779,共3页Miao Mao Zhe Pu Yuanqing Zhang 
support from the National Natural Science Foundation of China(82072087,31970893,32270976);funding by Science and Technology Projects in Guangzhou(202206010087,China).
Recently,a work jointly studied by Ling Li and coworkers1 was published in Nature Materials,describing a reconfigurable DNA origami nanodevice designed to regulate CD95 death-inducing signaling of immune cells.The res...
关键词：DNA origami Rheumatoid arthritis CD95 death-inducing signaling DNA nanostructure Drug delivery Receptoreligand interaction Cell signaling Drug intervention 
An AND-Gate DNA Nanodevice for Dual Protein-Mediated,Tumor-Specific Imaging
《Chinese Journal of Chemistry》2023年第12期1437-1442,共6页Zetan Fan Fangzhi Yu Mingming Yu Lele Li 
financially supported by the Beijing Natural Science Foundation(JQ20005).
Sensitive and specific imaging of tumor-associated biomarkers offers an effective way for cancer diagnosis.However,most of the reported imaging probes are limited to the targeting of a single biomarker,which may impai...
关键词：APTAMER DNA nanodevice Protein Sensor BIOIMAGING 
Exo/endogenous factors co-activatable nanodevice for spatiotem-porally controlled miRNA imaging and guided tumor ablation
《Nano Research》2022年第2期845-857,共13页Zhenqiang Wang Tao Ding Liucan Wang Shuai Wang Meizhen Zhou Jixi Zhang Kaiyong Cai 
supported in part by the National Natural Science Foundation of China(NSFC,Nos.51773022,51825302,21734002);Project No.2019CDQYSW041 supported by the Fundamental Research Funds for the Central Universities,Graduate Scientific Research and Innovation Foundation of Chongqing,China(No.CYB20068);the 100 Talents Program of Chongqing University(J.Z.)。
Remote activation of biomarker sensing holds a great promise of shifting the success of in vitro diagnostics to spatiotemporally controlled in vivo visualization of tumor,and in turn,imaging guided therapy.Herein,a"du...
关键词：thermo-activatable probe porous nanotransducer photothermal activation spatiotemporal miRNA imaging imaging-guided therapy 
A smart DNA nanodevice for ATP-activatable bioimaging and photodynamic therapy被引量：1
《Science China Chemistry》2020年第10期1490-1497,共8页Bei Liu Rui Ma Jian Zhao Yuliang Zhao Lele Li 
supported by the National Natural Science Foundation of China(21822401,21805060,21771044);the Young Thousand Talented Program。
Rational design of activatable photosensitizers for controlled generation of singlet oxygen remains a challenge for precise photodynamic therapy(PDT).Herein,we present an aptamer-based nanodevice for adenosine 5′-tri...
关键词：DNA nanotechnology ATP-activatable photodynamic therapy BIOIMAGING 
Highly sensitive detection of NT-proBNP by molecular motor被引量：1
《Genes & Diseases》2017年第1期37-40,共4页Jie Zhang Yao-Gen Shu 
This work is supported by the National Basic Research Program of China(973 Program)under grant No.2013CB932804;the National Natural Science Foundation of China under Grant No.11574329 and 11322543;the Science and Technology Planning Project of General Administration of Quality Supervision,Inspection and Quarantine(AQSIQ)of PR China under Grant No.2015IK011;AQSIQ industrial public service scientific research project of the Ministry of Science and Technology of P.R.China under Grant No.201410049;The YS101 type high sensitive detector of chemiluminescence was manufactured by Yishang Innovation Technology Co.,Ltd.
FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules dur...
关键词：Active nanodevice FoF1-ATPase Highly sensitive detection Molecular motor NT-PROBNP 
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