Γ-SECRETASE

作品数：23被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>
相关机构：东南大学清华大学第二军医大学台湾大学更多>>
相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>
相关基金：国家自然科学基金World Health Organization更多>>
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  • 学科=医药卫生—肿瘤x
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Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1
《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler 
This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.
Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...
关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease 
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells被引量：9
《World Journal of Gastroenterology》2015年第33期9727-9735,共9页Bing Han Shi-Hai Liu Wei-Dong Guo Bin Zhang Jian-Ping Wang Yu-Kun Cao Jun Liu 
Supported by Shandong Provincial Natural Science Foundation,China,No.ZR2012HQ039 and No.ZR2014HP065;National Natural Science Foundation of China,No.81373172 and No.81402579
AIM: To confirm the anti-invasion and anti-migration effects of down-regulation of Notch1 combined with interleukin(IL)-24 in hepatocellular carcinoma(HCC) cells.METHODS: γ-secretase inhibitors(GSIs) were used to dow...
关键词：NOTCH signaling pathway INTERLEUKIN-24 Γ-SECRETASE 
Sex effect on presenilins expression in post-natal rat brain
《Advances in Bioscience and Biotechnology》2013年第12期1086-1094,共9页Paola Piscopo Sonia Canterini Valentina Carletti Paolo Rosa Alessio Crestini Maria Teresa Fiorenza Annamaria Confaloni 
Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is r...
关键词：Development SEX PRESENILINS Γ-SECRETASE Rats Sexual DIMORPHISM 
Pharmacological Assessment of <i>γ</i>-Secretase Activity from Rodent and Human Brain
《Neuroscience & Medicine》2012年第2期149-161,共13页Christine E. Oborski Rathna Iyer Bruce A. Maguire Gary Bora Kevin Atchison Nikolay Pozdnyakov Kathleen Wood Christine Parker Timothy A. Subashi Martin Pettersson Douglas S. Johnson Kelly R. Bales 
γ-Secretase is involved in the final processing of the amyloid precursor protein into a heterogeneous pool of β-amyloid (Aβ) peptides. Current Alzheimer’s disease drug discovery efforts include targeting γ-secret...
关键词：Alzheimer’s Disease Amyloid Precursor Protein Aβ Γ-SECRETASE Pharmacology 
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