EXON

作品数：161被引量：414H指数：11
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Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma
《Frontiers of Medicine》2024年第6期1035-1053,共19页Bo Tian Yan Bian Yanan Pang Ye Gao Chuting Yu Xun Zhang Siwei Zhou Zhaoshen Li Lei Xin Han Lin Luowei Wang 
supported by Shanghai Science and Technology Innovation Action Program(No.21Y31900100).
Dysregulated RNA splicing events produce transcripts that facilitate esophageal squamous cell carcinoma(ESCC)progression,but how this splicing process is abnormally regulated remains elusive.Here,we unveiled a novel a...
关键词：esophageal squamous cell carcinoma alternative splicing exon skipping BOLA3 HNRNPC 
Truncated SCRIB isoform promotes breast cancer metastasis through HNRNP A1 mediated exon 16 skipping
《Acta Pharmacologica Sinica》2023年第11期2307-2321,共15页Bin Zhang Shao-han Xie Jun-yi Hu Si-jia Lei Liang-hua Shen Hong-tao Liu Qing Zheng Zhi-ming Zhang Chun-lian Wu Qiang Li Feng Wang 
supported by the Guangzhou Basic and Applied Basic Research Project(to FW);Natural Science Foundation of Guangdong Province(NO.2022A1515012636);High-level University Construction Project and 2019 Ministry of Education“Chunhui Plan”Cooperative Scientific Research Project(NO.131).
Breast cancer is one of the most common malignant tumors with high mortality due to metastases. SCRIB, a scaffold protein mainly distributed in the cell membrane, is a potential tumor suppressor. Mislocalization and a...
关键词：breast cancer scribble planar cell polarity protein(SCRIB) HnRNP A1 alternative splicing invasion ASO-SCRIB 
Sonic hedgehog signaling:Alternative splicing and pathogenic role in medulloblastoma被引量：2
《Genes & Diseases》2023年第5期2013-2028,共16页Meiyu Qu Qiangqiang He Jiahao Luo Tingyu Shen Ruibo Gao Yana Xu Chengyun Xu Muhammad Qasim Barkat Ling-Hui Zeng Ximei Wu 
supported by the National Natural Science Foundation of China(No.31571493,81741043,31871395,82000046,and 32170841).
Alternative splicing(AS)produces the different mRNA splicing bodies,which are then translated into multiple protein isoforms and participate in various biological functions.With a deeper understanding of alternative s...
关键词：Alternative splicing EXON Hedgehog signaling MEDULLOBLASTOMA Tumor suppressor 
Novel alternative splicing of GABA receptor RDL exon 9 from Laodelphax striatellus modulates agonist potency
《Insect Science》2021年第3期757-768,共12页Jie Jiang Li-Xin Huang Feng Chen Cheng-Wang Sheng Qiu-Tang Huang Zhao-Jun Han Chun-Qing Zhao 
the National Key R&D Program of China(grant No.2017YFD0200900);the Fundamental Research Funds for the Central Universities(grant No.KYZ201710);the National Natural Science Foundation of China(grant No.31871995).
The resistance to dieldrin gene(RDL)encodes the primary subunit of the insect ionotropic y-aminobutyric acid(GABA)receptor(GABAR),which is the target of phenylpyrazole and isoxazoline insecticides.The splice variants ...
关键词：alternative splicing exon 9 GABA receptor Laodelphax striatellus^RDL 
Regulation of alternative splicing of tau exon 10被引量：6
《Neuroscience Bulletin》2014年第2期367-377,共11页Wei Qian Fei Liu 
supported by Nantong University;New York State Institute for Basic Research in Developmental Disabilities;by grants from the National Natural Science Foundation of China(81030059 and 81170317);the Basic Research Program of Education Department of Jiangsu Province,China(10KJA310040);the U.S.Alzheimer’s Association(Grant IIRG-10-173154);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)of China
The neuronal microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in the brains of individuals with Alzheimer＇s disease and related neurodegenerative disord...
关键词：alternative splicing TAU tau exon 10 TAUOPATHIES 
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition被引量：19
《Cell Research》2013年第11期1256-1269,共14页Alika K Maunake Iouri Chepelev Kairong Cui Keji Zhao 
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body...
关键词：MECP2 splicing chromatin intragenic DNA methylation EPIGENOMICS histone acetylation 
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