METALLO-Β-LACTAMASE

作品数：30被引量：69H指数：6
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Virulence Factors and Biofilm Formation in Multidrug-Resistant Metallo-β-Lactamase-Producing Clinical Strains of Pseudomonas aeruginosa
《Advances in Microbiology》2024年第12期589-604,共16页Adjaratou Traore Comoé Koffi Donatien Benie Abdoulaye Diarrassouba Wako-Tianwa Alice Tuo Oby Zéphirin Wayoro Adjéhi Dadié Nathalie Guessennd Mireille Dosso 
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium, responsible for nosocomial infections, with a complex arsenal of pathogenicity. The aim of this study was to simultaneously characterize the potentia...
关键词：P. aeruginosa SEROGROUPS METALLO-Β-LACTAMASE VIRULENCE Biofilms 
The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers
《Engineering》2024年第7期124-132,共9页Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher Joseph Schofield Timothy Walsh 
supported by the Ineos Oxford Institute for Antimicrobial Research,the Biotechnology and Biological Sciences Research Council(BB/V003291/1);the WellcomeTrust(106244/Z/14/Z).
This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spect...
关键词：CARBAPENEMASE Metallo/serine-b-lactamase inhibitor Avibactam MEROPENEM Antimicrobial resistance 
Transmission patterns of multiple strains producing New Delhi metallo-β-lactamase variants among animals and the environment in live poultry markets
《One Health Advances》2024年第1期230-242,共13页Yi Yin Kai Peng Yan Li Wenhui Zhang Yanyun Gao Xinran Sun Sheng Chen Zhiqiang Wang Ruichao Li 
supported by the Sichuan Science and Technology Program(2022ZDZX0017);the National Natural Science Foundation of China(32161133005);the China Postdoctoral Science Foundation(2022T150555);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
The widespread transmission of bla_(NDM) among livestock and the live poultry industry attracts considerable pub-lic attention.However,studies have not yet addressed its impact on public health in live poultry markets...
关键词：Live poultry markets Antibiotic resistance genes bla_(NDM) Inter-host transmission 
Dissemination of carbapenem-non-susceptible Acinetobacter baumannii isolates collected from educational hospitals in Qazvin province of Iran
《Infectious Diseases Research》2024年第1期3-7,共5页Shahin Bolori Somayeh Alijani Zahra Hadi Saina Shegefti Amir Peymani Rasoul Samimi 
Qazvin University of Medical Sciences for supporting the project(Grant number:10016).
Background:Acinetobacter baumannii(A.baumannii)is known as an opportunistic pathogen related to health-care-associated infection that has a high antibiotic resistance potential,notably against carbapenems that are wid...
关键词：Acinetobacter baumannii CARBAPENEMASE Metallo-β-lactamases Repetitive extragenic palindromic(rep)-PCR 
Evaluation of Disk Potentiation Test (DPT) and Double Disk Synergy Test (DDST) for The Detection of Metallo-β-Lactamases (MBLs) in Clinical Isolates of Bangladesh
《Advances in Infectious Diseases》2023年第4期609-626,共18页Sumon Kumar Das Afzal Sheikh Nikhat Ara Suma Mita Biswas Abhinandan Chowdhury Fatimah Az Zahra Chaman Ara Keya 
Objective: Increasing the emergence of Metallo-β-lactamase (MBL) producing gram-negative bacteria and their dexterous horizontal transmission demands rapid and accurate detection. This study was conducted to determin...
关键词：Disk Potentiation Test (DPT) Double Disk Synergy Test (DDST) Metallo-β-Lactamase (MBL) Sodium Mercaptoacetate (SMA) and Ethylenediaminetetraacetic Acid (EDTA) 
Strategic design of lysine-targeted irreversible covalent NDM-1 inhibitors
《Chinese Chemical Letters》2023年第7期146-150,共5页Youzhen Ma Yongxi Liang Menglu Guo Delin Min Lulu Zheng Yun Tang Xun Sun 
funded by the National Natural Science Foundation of China (No. 82073688 to X. Sun and No. 82103971 to Y. Liang);Science and Technology Commission of Shanghai Municipality (No. 21S11907300 to X. Sun);Shanghai Science and Technology Development Fund from Central Leading Local Government (No. YDZX20223100001004 to X. Sun)。
New Delhi metallo-β-lactamase 1(NDM-1) can hydrolyze most β-lactam antibiotics, which is the major factor for drug resistance of Gram-negative bacteria. The binding of most reversible inhibitors to NDM-1 is relative...
关键词：Covalent inhibitors LYSINE IRREVERSIBLE METALLO-Β-LACTAMASE Antimicrobial activity 
Virtual screening and high-throughput testing of L1 metallo-β-lactamase inhibitor
《Journal of Chinese Pharmaceutical Sciences》2021年第10期806-812,共7页Chennan Liu Qian Wang Jiangxue Han Sihan Liu Chunling Xiao Yan Guan Xinghua Li Ying Wang Xiao Wang Jianzhou Meng Maoluo Gan Yishuang Liu 
Natural Sciences Foundation of China (Grant No. 81872913);National High-tech R&D Program (863 Program, Grant No. 2015AA020911)。
As a zinc-dependent enzyme, metal-β-lactamase L1 contributes to the development of β-lactam antibiotic resistance. The metal-β-lactamase inhibitor can restore the efficacy of β-lactam antibiotics, and its developm...
关键词：L1 Metallo-beta-lactamase inhibitor Virtual screening High-throughput screening 
(-)-Epicatechin gallate serves as a novel new delhi metallo-β-lactamase-1(NDM-1)inhibitor被引量：1
《Journal of Chinese Pharmaceutical Sciences》2021年第9期716-724,共9页Qian Wang Chennan Liu Jiangxue Han Sihan Liu Chunling Xiao Yan Guan Xinghua Li Ying Wang Xiao Wang Jianzhou Meng Maoluo Gan Yishuang Liu 
Natural Sciences Foundation of China(NSFC,Grant No.81872913);National High-tech R&D Program(863 Program,Grant No.2015AA020911)。
Theβ-lactam antibiotic resistance caused by NDM-1 has become a major crisis of global public health.We have previously screened out(-)-epicatechin gallate(ECG)as a potent NDM-1 inhibitor.We further discussed its inhi...
关键词：NDM-1 (-)-Epicatechin gallate INHIBITOR Antibiotics resistance 
Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1(NDM-1) inhibitors against NDM-1 producing clinical isolates被引量：2
《Acta Pharmaceutica Sinica B》2021年第1期203-221,共19页Bing Zhao Xinhui Zhang Tingting Yu Ying Liu Xiaoling Zhang Yongfang Yao Xuejian Feng Hongmin Liu Dequan Yu Liying Ma Shangshang Qin 
supported by National Natural Science Foundation of China(Grant Nos.81903447 for Bing Zhao,81903623 for Yongfang Yao,81703328 for Liying Ma,and 81430085 for Hongmin Liu);National Key Research and Development Project of China(Nos.2016YFA0501800 and 2018YFE0195100 for Hongmin Liu)
New Delhi metallo-b-lactamase-1(NDM-1)is capable of hydrolyzing nearly allβ-lactam antibiotics,posing an emerging threat to public health.There are currently less effective treatment options for treating NDM-1 positi...
关键词：Thiosemicarbazone derivatives New Delhi metallo-β-lactamase-1 Inhibitor Antibiotic resistance 
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse
《Protein & Cell》2020年第8期613-617,共5页Marcelo Monteiro Pedroso David W.Waite Okke Melse Liam Wilson Natasa Mitic Ross P.McGeary Iris Antes Luke W.Guddat Philip Hugenholtz Gerhard Schenk 
Dear Editor, Antibiotic resistance has emerged as a major threat to global health;multi-drug resistant bacteria already kill more patients in the United States each year than HIV/AIDS, Parkinson's disease, emphysema a...
关键词：HYDROXIDE metallo SPECTRUM 
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