supported by the National Natural Science Foundation of China (21991121);the National Key Research and Development Program of China (2021YFF0701700)。
Pentafluorosulfanylated(SF_(5^(-))) aromatics have shown great potential in drugs, and the bioisosteric replacement of aromatic ring with bicyclo[1.1.1]pentane(BCP) unit has attracted considerable attention recently. ...
the National Natural Science Foundation of China(Nos.21672037 and 21532001);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005)。
As a highly strained small molecule,[1.1.1]propellane has been widely used in various synthetic transformations owing to the exceptional reactivity of the central bond between the two bridgehead carbons.Utilizing stra...
supported by the National Natural Science Foundation of China(21722205,21971173);the Project of Scientific and Technologic Infrastructure of Suzhou(SZS201905);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
Rational design of new bioisosteres through introduction of high-value functional groups to bicyclo[1.1.1]pentane(BCP)is of particular use for drug discovery.Disclosed herein is the first access to valuable fluoroalky...
A highly chemoselective method for the synthesis of heterocyclic [3.3.3]propellane derivatives was developed via sequential three-component reactions of acenaphthenequinone, malononitrile/cyanoacetate and a variety of...