POLYPEPTIDE

作品数：239被引量：460H指数：9
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Emulsion interfacial polymerization of anticancer peptides:fabricating polypeptide nanospheres with high drug-loading efficiency and enhanced anticancer activity被引量：3
《Science China Chemistry》2022年第11期2252-2259,共8页Jinpeng Yang Hua Wang Zihe Yin Shuai Zhang Jiang-Fei Xu Xi Zhang 
financially supported by the Ministry of Science and Technology of China(2021YFA1501600,2018YFA0208900);the National Natural Science Foundation of China(21821001);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB36000000)。
The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanom...
关键词：emulsion interfacial polymerization drug delivery anticancer peptide self-assembly acidity-responsive 
Discovery of a novel sodium taurocholate cotransporting polypeptide(NTCP) inhibitor: Design, synthesis, and anti-proliferative activities被引量：1
《Chinese Chemical Letters》2020年第6期1422-1426,F0003,共6页Honggang Xiang Yanmei Chen Jifa Zhang jin Zhang Dabo Pan Bo Liu Liang Ouyang 
supported by National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX09735005);the National Natural Science Foundation of China(Nos.81922064,81874290,81673290,81803347 and 81903502);the Natural Science Foundation of Guangdong Province(No.2018A030313707);Post-Doctor Research Project,West China Hospital,Sichuan University(No.2019HXBH034)。
Sodium taurocholate cotransporting polypeptide(NTCP)is identified as the functional receptor for HBV entry,which is responsible for upregulated HBV transcription in the HBV life cycle.Besides,NTCP is also implicated i...
关键词：Sodium taurocholate cotransporting POLYPEPTIDE (NTCP) Hepatocellular carcinoma(HCC) HBV infection NTCP inhibitor Apoptosis 
The Achyranthes bidentata polypeptide k fraction enhances neuronal growth in vitro and promotes peripheral nerve regeneration after crush injury in vivo被引量：7
《Neural Regeneration Research》2014年第24期2142-2150,共9页Qiong Cheng Chunyi Jiang Caiping Wang Shu Yu Qi Zhang Xiaosong Gu Fei Ding 
supported by a grant from National Key Basic Research Program of China(973 Program),No.2014CB542202;a grant from Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)in China
We have previously shown that Achyranthes bidentata polypeptides （ABPP）, isolated from Achyranthes bidentata Blume （a medicinal herb）, exhibit neurotrophic and neuroprotective effects on the nervous system. To ide...
关键词：nerve regeneration Achyranthes bidentata polypeptides neuroactive component dorsal root ganglion neurite outgrowth crush injury sciatic nerve peripheral nerve regeneration neural regeneration 
The relative energies of polypeptide conformers predicted by linear scaling second-order M?ller-Plesset perturbation theory
《Science China Chemistry》2014年第10期1393-1398,共6页GUO Yang LI Wei YUAN DanDan LI ShuHua 
supported by the National Natural Science Foundation of China(21073086,21333004);the National Basic Research Program of China(2011CB808501)
We describe an implementation of the cluster-in-molecule （CIM） resolution of the identity （RI） approximation second-order Moller-Plesset perturbation theory （CIM-RI-MP2）, with the purpose of extending RI-MP2 cal...
关键词：cluster-in-molecule generalized energy-based fragmentation second-order Moller-Plesset perturbation theory resolution of the identity relative energy 
A wound-induced small polypeptide gene family is upregulated in soybean nodules被引量：2
《Chinese Science Bulletin》2013年第9期1003-1009,共7页LI XiaoLin XU Ji YU GuanQiao LUO Li 
supported by National Key Basic Research Program of China(2011CB100702 and 2010CB126501);National Natural Science Foundation of China(31070218);Shanghai Municipal Natural Science Foundation(09ZR1436500);Knowledge Innovation Program of Chinese Academy of Sciences(2009KIP206)
Small peptides function as key signals in processes,such as plant cell differentiation,organ development and defenses to biotic stresses.A large number of small peptide precursor genes have been predicted from the ana...
关键词：基因家族 大豆根瘤 多肽 创伤诱导 蛋白质结构预测 第6号染色体 绿色荧光蛋白 12号染色体 
A BIOREDUCIBLE POLYPEPTIDE FOR EFFICIENT GENE TRANSFECTION BOTH IN VITRO AND IN VIVO
《Chinese Journal of Polymer Science》2013年第5期713-713,714-718,共6页Wei Qu Si Chen Shan Ren Xue-jun Jiang Ren-xi Zhuo 张先正 
financially supported by the National Natural Science Foundation of China(Nos.51125014,51233003);the Ministry of Science and Technology of China(2011CB606202)
A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obta...
关键词：Gene vector POLYPEPTIDE ANGIOGENESIS Limb ischemia. 
Identification of AtSM34, a novel tonoplast intrinsic protein-interacting polypeptide expressed in response to osmotic stress in germinating seedlings被引量：3
《Chinese Science Bulletin》2011年第33期3518-3530,共13页LI LiJuan REN Fei WEI PengCheng CHEN QiJun CHEN Jia WANG XueChen 
supported by the National Natural Science Foundation of China (30770193);the National Basic Research Program of China (2006CB100100);the "111 Project" (B06003)
Aquaporins are implicated in a wide variety of plant physiological processes, although the mechanisms involved in their regulation are not fully understood. To gain further insight into the regulatory factors involved...
关键词：蛋白质相互作用 渗透胁迫 液泡膜 幼苗 多肽 酵母双杂交系统 组织化学染色 鉴定 
Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites被引量：3
《Science China Chemistry》2011年第3期431-437,共7页WEI JunChao DAI YanFeng CHEN YiWang CHEN XueSi 
supported by the National Natural Science Foundation of China (50733003);the International Cooperation Fund of Science and Technology (20071314) from the Ministry of Science and Technology of China;the fund from Chinese Academy of Sciences (KGCX-YW-208)
A new type of polypeptide(poly(-benzyl-L-glutamate)(PBLG))modified hydroxyapatite(HA)/poly(L-lactide)(PLLA)nanocomposites(PBLG-g-HA/PLLA)were prepared by the solvent-mixing method,and their mechanical and thermal prop...
关键词：HYDROXYAPATITE poly（L-lactide） NANOCOMPOSITE surface modification 
Polypeptide dendrimers: Self-assembly and drug delivery被引量：6
《Science China Chemistry》2011年第2期326-333,共8页XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU ZhongWei 
supported by the National Basic Research Program of China (973 Program,2011CB606206);National High-Tech Research & Development Program of China (863 Program,2007AA021801);National Natural Science Foundation of China (50633020 & 50830105);Sichuan Youth Science & Technology Foundation (07ZQ026-013);Open Fund of Engineering Research Center of Biomass Materials,Ministry of Education (2010LF4002)
Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The ...
关键词：serf-assembly dendritic polypeptide block copolymer drug delivery 
Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit被引量：1
《Protein & Cell》2010年第4期406-416,共11页Lanfeng Wang Wenchi Zhang Lu Wang Xuejun C.Zhang Xuemei Li Zihe Rao 
This work was supported by the National Natural Science Foundation of China(grant No.30730022);the National Basic Research Program(973 Program)(grant Nos.2006CB806503 and 2007CB914304);the National Programs for High Technology Research and Development Program(863 Program)(grant Nos.2006AA02A322 and 2006AA020502);the CAS(China)grant KSCX2-YW-R-05 to Z.R.
Nascent polypeptide associated complex(NAC)and its two isolated subunits,αNAC and βNAC,play important roles in nascent peptide targeting.We determined a 1.9Åresolution crystal structure of the interaction core of NA...
关键词：nascent polypeptide-associated complex αNAC homodimer βNAC crystal structure 
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