POLYPEPTIDE

作品数：239被引量：460H指数：9
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Accelerated heterogenous ring-opening polymerization towards well-defined helical poly(N-allyl alanine)with clickable side chains
《Science China Chemistry》2024年第6期2056-2062,共7页Anyao Ma Xin Wang Sunting Xuan Zhengbiao Zhang 
supported by the National Natural Science Foundation of China(22201197,21925107);the Collaborative Innovation Center of Suzhou Nano Science and Technology,National Key R&D Program of China(2022YFB3704900);the Natural Science Foundation of Jiangsu Province(BK20220507);the Natural Science Foundation of Jiangsu Higher Education Institutions(21KJB150035)。
Well-defined poly(N-allyl alanine)has been synthesized by heterogenous ring-opening polymerization(HROP)of less reactive N-allyl-alanine N-carboxyanhydride,using acetic acid as the catalyst and benzylamine as the init...
关键词：heterogenous ring-opening polymerization controlled polymerization stable helix clickable N-substituted polypeptide di-substituted polypeptoid 
Emulsion interfacial polymerization of anticancer peptides:fabricating polypeptide nanospheres with high drug-loading efficiency and enhanced anticancer activity被引量：3
《Science China Chemistry》2022年第11期2252-2259,共8页Jinpeng Yang Hua Wang Zihe Yin Shuai Zhang Jiang-Fei Xu Xi Zhang 
financially supported by the Ministry of Science and Technology of China(2021YFA1501600,2018YFA0208900);the National Natural Science Foundation of China(21821001);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB36000000)。
The development of drug delivery systems with high drug-loading efficiency, kinetic stability against dilution, as well as enhanced anticancer activity is of crucial importance to the fields of self-assembly and nanom...
关键词：emulsion interfacial polymerization drug delivery anticancer peptide self-assembly acidity-responsive 
Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics被引量：3
《Science China Chemistry》2021年第2期293-301,共9页Xiangru Feng Weiguo Xu Xiaoru Xu Gao Li Jianxun Ding Xuesi Chen 
the National Natural Science Foundation of China(52022095,51973216,51873207,51803006,51833010,51673190,51603204);the Science and Technology Development Program of Jilin Province(20200404182YY);the Youth Talents Promotion Project of Jilin Province(181909);the Youth Innovation Promotion Association of Chinese Academy of Sciences(2019230)。
The physicochemical characteristics of nanoparticles are closely related to their drug delivery performances in vitro and in vivo.A well-designed nanocarrier can prolong the drug half-life in the blood circulation,upr...
关键词：polypeptide nanogel cystine proportion fate of nanocarrier controlled drug delivery cancer therapy 
Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells被引量：7
《Science China Chemistry》2020年第8期1100-1111,共12页Yan Rong Zhen Zhang Chaoliang He Xuesi Chen 
supported by the National Natural Science Foundation of China(51973218,51622307,21574127,51520105004);the Youth Innovation Promotion Association,Chinese Academy of Sciences。
Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell behavior.In the present study,poly(L-glutamic acid)(PLG)hydrogels were prepared by catalyst-free click crosslinking via ...
关键词：polypeptide hydrogel click crosslinking BIOFUNCTIONALIZATION 3D cell culture tissue engineering 
Tunable supramolecular hydrogels from polypeptidePEG-polypeptide triblock copolymers被引量：2
《Science China Chemistry》2015年第6期1005-1012,共8页Xiaohui Fu Yong Shen Yinan Ma Wenxin Fu Zhibo Li 
financially supported by the National Natural Science Foundation of China for Distinguished Young Scholar(51225306);the CAS-CSIRO Cooperative Research Program(GJHZ1408)
A series of ABA triblock copolymers of poly(?-(2-methoxy ethoxy)esteryl-glutamate)-block-poly(ethylene glycol)-blockpoly(?-(2-methoxy ethoxy)esteryl-glutamate) with poly(ethylene glycol) as middle hydrophilic B block ...
关键词：HYDROGEL POLYPEPTIDE N-carboxyanhydride （NCA） ring-opening polymerization （ROP） drug delivery 
The relative energies of polypeptide conformers predicted by linear scaling second-order M?ller-Plesset perturbation theory
《Science China Chemistry》2014年第10期1393-1398,共6页GUO Yang LI Wei YUAN DanDan LI ShuHua 
supported by the National Natural Science Foundation of China(21073086,21333004);the National Basic Research Program of China(2011CB808501)
We describe an implementation of the cluster-in-molecule （CIM） resolution of the identity （RI） approximation second-order Moller-Plesset perturbation theory （CIM-RI-MP2）, with the purpose of extending RI-MP2 cal...
关键词：cluster-in-molecule generalized energy-based fragmentation second-order Moller-Plesset perturbation theory resolution of the identity relative energy 
Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites被引量：3
《Science China Chemistry》2011年第3期431-437,共7页WEI JunChao DAI YanFeng CHEN YiWang CHEN XueSi 
supported by the National Natural Science Foundation of China (50733003);the International Cooperation Fund of Science and Technology (20071314) from the Ministry of Science and Technology of China;the fund from Chinese Academy of Sciences (KGCX-YW-208)
A new type of polypeptide(poly(-benzyl-L-glutamate)(PBLG))modified hydroxyapatite(HA)/poly(L-lactide)(PLLA)nanocomposites(PBLG-g-HA/PLLA)were prepared by the solvent-mixing method,and their mechanical and thermal prop...
关键词：HYDROXYAPATITE poly（L-lactide） NANOCOMPOSITE surface modification 
Polypeptide dendrimers: Self-assembly and drug delivery被引量：6
《Science China Chemistry》2011年第2期326-333,共8页XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU ZhongWei 
supported by the National Basic Research Program of China (973 Program,2011CB606206);National High-Tech Research & Development Program of China (863 Program,2007AA021801);National Natural Science Foundation of China (50633020 & 50830105);Sichuan Youth Science & Technology Foundation (07ZQ026-013);Open Fund of Engineering Research Center of Biomass Materials,Ministry of Education (2010LF4002)
Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The ...
关键词：serf-assembly dendritic polypeptide block copolymer drug delivery 
Effect of external field on phase behavior of ternary systems involving polypeptide
《Science China Chemistry》2005年第2期132-142,共11页LIN Shaoliang LIN Jiaping CHEN Tao TIAN Xiaohui 
the National Natural Science Foundation of China(Grant No.50273011);Supports from Doctoral Foundation of Education Minis try of China(Grant No.20010251008);Shanghai Nami Project(Grant No.0352nm109)are also appreciated.
The lattice theory regarding ternary systems involving a conformationally variable polypeptide and a randomly coiled polymer presented recently is extended to the case where an external orientational field is present....
关键词：lattice theory POLYPEPTIDE external field phase behavior chain conformation. 
Special Reaction and Polypeptide Analysis of Apple Rootstock Calli Under Iron Deficiency Stress
《Science China Chemistry》1994年第12期1463-1470,共8页卞学渝 李港丽 苏润宇 陈正华 
the National Natural Science Foundation of China.
The callus experiment systems derived from sterile stem segments subject to subcultures have been established for Malus baccata(L.)Borkh that is sensitive to iron deficiency stress,and for M.mi- cromalus Makino that i...
关键词：apple ROOT STOCK CALLUS iron DEFICIENCY POLYPEPTIDE analysis. 
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