POLYPEPTIDE

作品数：239被引量：460H指数：9
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On the origin of the low immunogenicity and biosafety of a neutralα-helical polypeptide as an alternative to polyethylene glycol
《Bioactive Materials》2024年第2期333-343,共11页Jialing Sun Junyi Chen Yiming Sun Yingqin Hou Zhibo Liu Hua Lu 
supported by the National Key Research and Development Program of China(2019YFA0904203);Beijing Natural Science Foundation Key Project(Z220023);the National Natural Science Foundation of China(NSFC)for Distinguished Young Investigators(22125101).
Poly(ethylene glycol)(PEG)is a prominent synthetic polymer widely used in biomedicine.Despite its notable success,recent clinical evidence highlights concerns regarding the immunogenicity and adverse effects associate...
关键词：HELICAL NEUTRAL activation 
An immunomodulatory polypeptide hydrogel for osteochondral defect repair被引量：3
《Bioactive Materials》2023年第1期678-689,共12页Meng Yang Zheng-Chu Zhang Fu-Zhen Yuan Rong-Hui Deng Xin Yan Feng-Biao Mao You-Rong Chen Hua Lu Jia-Kuo Yu 
supported by the Beijing Natural Science Foundation(L192066);the National Natural Science Foundation of China(22125101,51773004,51920105006,82102565,52003008);the Construction of a Basic Public Service Platform for Industrial Technology in the Field of Advanced Medical Equipment(0714-EMTC-02-00897).
Osteochondral injury is a common and frequent orthopedic disease that can lead to more serious degenerative joint disease.Tissue engineering is a promising modality for osteochondral repair,but the implanted scaffolds...
关键词：Osteochondral regeneration Polypeptide hydrogel IMMUNOREGULATION Foreign-body reaction Mesenchymal stem cells 
Calcium-mineralized polypeptide nanoparticle for intracellular drug delivery in osteosarcoma chemotherapy被引量：8
《Bioactive Materials》2020年第3期721-731,共11页Ke Li Di Li Li Zhao Yonghe Chang Yi Zhang Yan Cui Zhiyu Zhang 
financially supported by the National Natural Science Foundation of China(Grant No.51803006);the Scientific Development Program of Liaoning Province(Grant No.20170541058);the China Postdoctoral Science Foundation(Grant No.2019M650297).
The acidic microenvironments of tumor tissue and cells provide an opportunity for the development of pHresponsive drug delivery systems in cancer therapy.In this work,we designed a calcium carbonate(CaCO3)-corecrossli...
关键词：POLYPEPTIDE Calcium mineralization Controlled drug release pH-responsiveness Osteosarcoma chemotherapy 
Corrigendum to “DOX/IL-2/IFN-γ co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment” [Bioact. Mater. 3 (2018) 118–128]
《Bioactive Materials》2019年第1期167-167,共1页Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen 
The“nude mice model”mentioned both in line 12 of the abstract and in line 5 of the right column on page 119 should be corrected into“BALB/C mice model”.The other parts of the main text and conclusions are correct....
关键词：NUDE MELANOMA Cor 
DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment被引量：11
《Bioactive Materials》2018年第1期118-128,共11页Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen 
The financial support from the National Natural Science Foundation of China(No.51403202,51622307,51390484,51520105004)are gratefully thanked.
Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.I...
关键词：Polypeptide hydrogel Sustained co-delivery Combination therapy Local cancer treatment Thermosensitive hydrogel 
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