云南高校图书馆联盟文献共享服务平台- NORCANTHARIDIN

NORCANTHARIDIN: 作品数：21被引量：159H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：冼励坚蔡于琛邹永王志新周玥更多>>; 相关机构：中国科学院中山大学西北农林科技大学更多>>; 相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Hepatobiliary & Pancreatic Diseases International》更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划更多>>

Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells被引量：4: 《Acta Pharmacologica Sinica》2022年第6期1521-1533,共13页Li-jun Du Yu-xiang Feng Zhi-xing He Lin Huang Qiao Wang Cheng-ping Wen Yun Zhang; This work was supported by the National Natural Science Foundation of China(No.82074375);Natural Science Foundation of Zhejiang Province(No.LY20H270007);TCM Science and Technology Plan of Zhejiang Province(No.2020ZQ012);the Research Project of Zhejiang Chinese Medical University(No.2021JKZKTS003A)to YZ;National Natural Science Foundation of China(No.82074217)to ZXH.; Systemic lupus erythematosus(SLE)is a devastating autoimmune disorder associated with severe organ damage.The abnormality of T cell apoptosis is considered as an important pathogenetic mechanism of SLE.Norcantharidin(...; 关键词：systemic lupus erythematosus NORCANTHARIDIN DN T cell proliferation Th17 cell differentiation IL-17 STAT3 MRL/lpr mice

Metal-organic framework IRMOFs coated with a temperaturesensitive gel delivering norcantharidin to treat liver cancer被引量：3: 《World Journal of Gastroenterology》2021年第26期4208-4220,共13页Xiu-Yan Li Qing-Xia Guan Yu-Zhou Shang Yan-Hong Wang Shao-Wa Lv Zhi-Xin Yang Rui Wang Yu-Fei Feng Wei-Nan Li Yong-Ji Li; Supported by National Natural Science Foundation of China,No.82074025 and No.82074271;the Heilongjiang Traditional Chinese Medicine Research Project,No.ZHY18-047;and Scientific Research Project of Heilongjiang Health Committee,No.2020-293.; BACKGROUND Norcantharidin(NCTD)is suitable for the treatment of primary liver cancer,especially early and middle primary liver cancer.This compound can reduce tumors and improve immune function.However,the side effect...; 关键词：NORCANTHARIDIN Metal-organic frameworks IRMOF-3 Temperature-sensitive gel Drug delivery Liver cancer

Protective Effect of Norcantharidin on Collagen-Induced Arthritis Rats被引量：9: 《Chinese Journal of Integrative Medicine》2018年第4期278-283,共6页SHEN Hong-bo HUO Ze-jun BAI Yun-jing HE Xiao-juan LI Chang-hong ZHAO Yu-kun GUO Qing-qing; Supported by the National Natural Science Foundation of China(No.81273837); Objective： To observe the effect of norcantharidin（NCTD） on collagen-induced arthritis（CIA） rats. Methods： Sixty Sprague-Dawley（SD） rats were randomly divided into 6 groups（n=10）： normal group, CIA model gr...; 关键词：NORCANTHARIDIN collagen-induced arthritis CYTOKINE TH17/TREG forkhead box P3 retinoid related orphan nuclear receptor γt

Norcantharidin combined with ABT-737 for hepatocellular carcinoma: Therapeutic effects and molecular mechanisms被引量：9: 《World Journal of Gastroenterology》2016年第15期3962-3968,共7页Jing Ren Gang Li Wen Zhao Ling Lin Tao Ye; AIM: To study the therapeutic effect of norcantharidin(NCTD) combined with ABT-737 on hepatocellular carcinoma cells and the molecular mechanism. METHODS: Two hepatocellular carcinoma(HCC) cell lines, Hep G2 and SMMC-...; 关键词：NORCANTHARIDIN HEPATOCELLULAR CARCINOMA cell MCL-1

Norcantharidin inhibits renal interstitial fibrosis through down-regulating protein phosphatase 2Ac: 《China Medical Abstracts(Internal Medicine)》2014年第2期114-115,共2页尤燕华; Objective To observe the relationship between protein phosphatase-2Ac(PP2Ac)and renal interstitial fibrosis,and to investigate the effects and the underlying mechanism of norcantharidin(NCTD)on renal fibrosis in unila...; 关键词：interstitial ureteral REGULATING UNILATERAL OBSTRUCTION FIBRONECTIN underlying collagen saline CADHERIN

Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K /MMPs /Ln-5γ2 signaling pathway被引量：18: 《外科研究与新技术》2014年第1期59-59,共1页ZHANG Jing-tao SUN Wei ZHANG Wen-zhong GE Chun-yan LIU Zhong-yan ZHAO Zhe-ming LU Xing-sui FAN Yue-zu; Background:Vasculogenic mimicry(VM)is a novel tumor blood supply in some highly aggressive malignant tumors.Recently,we reported VM existed in gallbladder carcinomas(GBCs)and the formation of the special passage throu...; 关键词：胆囊癌肿瘤治疗方法临床分析

Inhibition of tumor vasculogenic mimicry and prolongation of host survival in highly aggressive gallbladder cancers by norcantharidin via blocking the ephrin type a receptor2 /focal adhesion kinase /Paxillin signaling pathway被引量：3: 《外科研究与新技术》2014年第1期64-64,共1页WNAG Hui SUN Wei ZHANG Wen-zhong GE Chun-yan ZHANG Jing-tao LIU Zhong-yan FAN Yue-zu; Vasculogenic mimicry(VM)is a newly-defined tumor microcirculation pattern in highly aggressive malignant tumors.We recently reported tumor growth and VM formation of gallbladder cancers through the contribution of the...; 关键词：恶性肿瘤治疗方法临床分析人胆囊癌

Induction of Apoptosis in Human Hep3B Hepatoma Cells by Norcantharidin through a p53 Independent Pathway via TRAIL/DR5 Signal Transduction被引量：7: 《Chinese Journal of Integrative Medicine》2012年第9期676-682,共7页叶宗勋杨玉燕黄雅芳周宽基陈明丰; Supported by Show Chwan Memorial Hospital; Objective： To investigate the inhibitory activities of norcantharidin （NCTD）, a demethylated analogue of cantharidin, on Hep3B cells （a human hepatoma cell line） with deficiency of p53. Methods： The survival rat...; 关键词：NORCANTHARIDIN caspase APOPTOSIS death receptors

Synthesis, Antiproliferative Activity and DNA-Binding Properties of Nitrogen and Sulfur Heterocyclic Norcantharidin Acylamide Acid: 《Chinese Journal of Chemistry》2011年第3期473-477,共5页Wang, Na Wang, Yunyun Wang, Xiaoxia Zheng, Xiaoliang Yan, Dongmei Lin, Qiuyue; Project supported by the Natural Science Foundation of-Zhejiang Province, China （No. Y407301）.; Three novel norcantharidin acylamide acids （L1 =N-thiadiazole norcantharidin acylamide acid, CIoHIlN304S; L2=N-thiazole norcantharidin acylamide acid, CjIHI2N204S and L3=N-benzothiazole norcantharidin acylamide acid,...; 关键词：NORCANTHARIDIN DNA fluorescence spectroscopy antiproliferative activity

Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo被引量：15: 《Hepatobiliary & Pancreatic Diseases International》2010年第4期414-422,共9页Fan, Yue-Zu Zhao, Ze-Ming Fu, Jin-Ye Chen, Chun-Qiu Sun, Wei; BACKGROUND: Gallbladder carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. We previously reported that norcantharidin (NCTD) is useful against g...; 关键词：NORCANTHARIDIN gallbladder neoplasm tumor growth APOPTOSIS cell cycle

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