VINCAMINE

作品数：6被引量：6H指数：2
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相关期刊：《Green Synthesis and Catalysis》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》《Chinese Journal of Chemistry》更多>>
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Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice被引量：3
《Acta Pharmacologica Sinica》2023年第12期2388-2403,共16页Jia-wen Xu Xu Xu Yun Ling Yan-chun Wang Yu-jie Huang Juan-zhen Yang Jia-ying Wang Xu Shen 
the National Natural Science Foundation of China(82273930);Innovative Research Team of Six Talent Peaks Project in Jiangsu Province(TD-SWYY-013);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(No.2020YLXK018)and“Qing Lan”project.
Diabetic peripheral neuropathy(DPN)is a common complication of diabetes,which has yet no curable medication.Neuroinflammation and mitochondrial dysfunction are tightly linked to DPN pathology.G-protein-coupled recepto...
关键词：diabetic peripheral neuropathy VINCAMINE GPR40 dorsal root ganglia sciatic nerve 
Unified total synthesis of eburnamine-vincamine indole alkaloids based on catalytic asymmetric hydrogenation/lactamization cascade
《Green Synthesis and Catalysis》2022年第3期291-293,共3页Wen Zhang Yansong Xue Srihari Konduri Guodan Lin Mengjuan Wu Pei Tang Fener Chen 
support from the National Natural Science Foundation of China(No.U21A20278);the Sichuan Science and Technology Program(No.2021YJ0221).
The enantioselective total synthesis of representative members of the eburnamine-vincamine alkaloids(+)-vincamine,(-)-eburnamonine,and(-)-criocerine has been accomplished.The synthesis took advantage of a highly stere...
关键词：Indole alkaloid IMINE Asymmetric hydrogenation Natural product Enantioselective synthesis 
Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon被引量：2
《Chinese Journal of Chemistry》2022年第4期475-479,共5页Wen-Fang Yi Tiwalade A.Adelakun Xue Bai Yu Zhang Xiao-Jiang Hao 
supported financially by grants from NSFC(81874295);Top Young Talent of the Ten Thousand Talents Program of Yunnan(to Y.Zhang).
Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isola...
关键词：Natural products ALKALOIDS Structure elucidation Tabernaemontana pachysiphon Tabernaesine J 
Enantioselective total synthesis of (+)-vincamine
《Chinese Chemical Letters》2022年第4期2044-2046,共3页Fanglin Xue Hengmao Liu Rui Wang Dan Zhang Hao Song Xiao-Yu Liu Yong Qin 
National Natural Science Foundation of China (Nos. 21991114, 21921002 and 21732005) for financial support。
A catalytic asymmetric total synthesis of(+)-vincamine is presented. Key features of the synthesis include a Pd-catalyzed enantioselective decarboxylative allylation to form the C20 quaternary stereogenic center and a...
关键词：Indole alkaloid Decarboxylative allylation Stereoselective iminium reduction Natural product Total synthesis 
Asymmetric Total Synthesis of (+)-21-epi-Eburnamonine Via a Photocatalytic Radical Cascade Reaction
《Natural Products and Bioprospecting》2021年第1期99-103,共5页Yuan Huang Fanglin Xue Hengmao Liu Fei Xue Xiao-Yu Liu Hao Song Yong Qin 
surpport from National Natural Science Foundation of China(21921002 and 21991114);National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(2018ZX09711003-015 and 2018ZX09711001-005-004).
An asymmetric total synthesis of(+)-21-epi-eburnamonine has been achieved.Key features of the synthesis include a visible-light photocatalytic intra-/intramolecular radical cascade reaction to assemble the tetracyclic...
关键词：Eburnamine-vincamine alkaloids PHOTOCHEMISTRY Radical cascade reaction Johnson-claisen rearrangement 
Beneficial effects of vincamine with thioctic acid and lutein on retinal and optic nerve functions in an opaque media被引量：1
《International Journal of Ophthalmology(English edition)》2019年第9期1450-1455,共6页Mona Abdelkader Sameh Saleh Tharwat Mokbel Hossam Abouelkheir Ayman Abd El Ghafar 
AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or not.METHODS: T...
关键词：RETINA optic NERVE opaque MEDIA thioctic acid with cyanocobalamine VINCAMINE LUTEIN 
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