PRODRUG

作品数：209被引量：333H指数：7
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相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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  • 期刊=Chinese Journal of Polymer Sciencex
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Triclosan-conjugated,Lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms
《Chinese Journal of Polymer Science》2024年第6期718-728,共11页Yan-Qiang Huang Yuan-Feng Li Yong Liu Lin-Qi Shi 
supported by the National Natural Science Foundation of China(Nos.22275043,52203184,52293380 and 52293383);Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(Nos.WIUCASQD2021022 and WIUCASQD2021019).
Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative nanomedicines.In this study,we introduce triclosan-conjugated,lipase-responsive poly...
关键词：Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity 
Paclitaxel Prodrug Nanomedicine for Potential CT-imaging Guided Breast Cancer Therapy
《Chinese Journal of Polymer Science》2023年第11期1747-1759,I0008,共14页Jia-Wei Chen Yi Shen Qing-Song Yu Zhi-Hua Gan 
the National Natural Science Foundation of China(Nos.51973014,52033001 and 21774008);the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC for BUCT;the Fundamental Research Funds for the Central Universities of China(Nos.BUCTRC201912,XK1701 and XK18028)。
Nanotheranostics,which combine the therapeutic and diagnostic functions in one integrated system,have received extensive attentions in cancer treatments because they enable non-invasive diagnosis,tumor-targeted drug d...
关键词：CT imaging PACLITAXEL PRODRUG GSH responsiveness Polymeric nanoparticles 
A Redox-responsive Prodrug Nanogel of TLR7/8 Agonist for Improved Cancer Immunotherapy
《Chinese Journal of Polymer Science》2023年第1期32-39,共8页Kai-Shuo Wang Yu-Feng Jin Qi-Song Tong Yong-Cong Huang Zhen-Lin Gao Sui-Juan Zheng Jing-Yang Zhang Jun Wang Jin-Zhi Du 
the National Natural Science Foundation of China(Nos.51922043,52173122 and 31771091);Guangdong Provincial Program(No.2017GC010304);Science and Technology Planning Project of Ganzhou(No.202101074816);Fundamental Research Funds for Central Universities.
The existence of tumor immunosuppressive microenvironment(TIME)is the major determinant for the poor efficacy of current tumor immunotherapy.Tumor-associated macrophages(TAMs)tend to become tumor-promoting M2-like phe...
关键词：NANOGEL Drug delivery Tumor-associated macrophage Macrophage repolarization Cancer immunotherapy 
Monoclonal Antibody-conjugated Polyphosphoester-hyd-DOX Prodrug Nanoparticles for Targeted Chemotherapy of Liver Cancer Cells被引量：1
《Chinese Journal of Polymer Science》2021年第11期1392-1402,共11页Ya-Kui Huang Hong-Rui Tian Ming-Zu Zhang Jin-Lin He Jian Liu Pei-Hong Ni 
financial supports from the National Natural Science Foundation of China(Nos.21975169 and 21374066);the Natural Science Foundation of Jiangsu Province(No.BK20171212);Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions。
In order to overcome the limitation of traditional active nano-therapeutic drugs on tumor targeting efficiency which cannot reach the receptor/target in sufficient amount in the body,in this work,we developed a monocl...
关键词：Monoclonal antibody Polymeric prodrug POLYPHOSPHOESTER Drug delivery Targeted therapy 
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