REPLICON

作品数：23被引量：29H指数：3
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相关领域：医药卫生更多>>
相关作者：仇华吉更多>>
相关机构：中国农业科学院哈尔滨兽医研究所更多>>
相关期刊：《Chinese Journal of Chemical Engineering》《Open Journal of Medicinal Chemistry》《Science China(Life Sciences)》《Science China Chemistry》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家高技术研究发展计划International Foundation for Science更多>>
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Anthocyanin-assisted Agrobacterium infiltration for the rapid evaluation of genome editing efficiencies across multiple plant species被引量：1
《National Science Open》2023年第5期11-24,共14页Sinian Xing Yu Sun Boshu Li Hongchao Li Kevin T.Zhao Kunling Chen Caixia Gao 
supported by the National Natural Science Foundation of China(31788103 and 31971370);the National Key Research and Development Program(2022YFF1002802);the Ministry of Agriculture and Rural Affairs of China,and the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision Seed Design and Breeding,XDA24020102).
CRISPR-based genome editing technologies continue to drive major advances in life sciences.A major challenge for realizing widespread use of genome editing in plants and agriculture is establishing methods that enable...
关键词：genome editing Agrobacterium infiltration ANTHOCYANIN transient transformation geminivirus replicon strawberry tomato 
Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin(Manis javanica)
《Integrative Zoology》2023年第2期289-298,共10页Fang JI Shelan LIU Xue WANG Jianan ZHAO Jiayue ZHU Jianchun YANG Chenglin ZHANG Zhongxin JIA Ruili ZHAO Guocheng HU Jing WANG Jianhua QIN Gang LI Bin WU Chengmin WANG 
supported by the Introduction of Leading Talents Program of the Guangdong Academy of Sciences(No.2016GDASRC-0205);the Open project of Beijing Key Laboratory of captive wildlife technology in Beijing Zoo(ZDK202105).
Potential zoonotic pathogens may be transmitted from wildlife to humans through the illegal wild meat trade,which has become a pressing issue.However,research on the antimicrobial resistance genes(ARGs)of Malayan pang...
关键词：ARG Manis javanica multiple-replicon plasmid IncX1-X1 plasmid IncX1 
Molecular characterization and antibiotic resistance of Salmonella enterica serovar 1,4,[5],12:i:-environmental isolates from poultry farms
《Food Quality and Safety》2022年第4期579-587,共9页Xiaojie Qin Linlin Xiao Jiaming Li Mingzhe Yang Changying Yang Qingli Dong 
supported by the National Natural Science Foundation of China(No.32102111);the Project was funded by the China Postdoctoral Science Foundation(2021M702194).
Salmonella enterica serovar 1,4,[5],12:i:-(S.1,4,[5],12:i:-)has been recognized as an emerging foodborne pathogen in recent years.It can cause human salmonellosis predominated by the contamination of animal-derived fo...
关键词：Salmonella enterica serovar 1 4 [5] 12:i:- PFGE typing MLST typing plasmid replicon typing antibiotic resistance food safety 
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and release被引量：1
《Virologica Sinica》2022年第5期695-703,共9页Lingqian Tian Qiuhong Liu Rongjuan Pei Yingshan Chen Chonghui Xu Jielin Tang Hao Sun Kunpeng Liu Qi Yang Lei Yang Leshan Li Yongli Zhang Yuan Zhou Chao Shan Xue Hu Xinwen Chen Yun Wang 
supported by grants from the National Key Research and Development Project of China (2020YFC0845900);the China Postdoctoral Science Foundation (2020T130021ZX,2021M693198)
Several variants of concern(VOCs)have emerged since the WIV04 strain of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first isolated in January 2020.Due to mutations in the spike(S)protein,these VOCs ...
关键词：SARS-CoV-2 Variants of concern(VOC) Viral-like particle(VLP) REPLICON Remdesivir 
Construction of Non-infectious SARS-CoV-2 Replicons and Their Application in Drug Evaluation被引量：6
《Virologica Sinica》2021年第5期890-900,共11页Bei Wang Chongyang Zhang Xiaobo Lei Lili Ren He Huang Jianwei Wang Zhendong Zhao 
supported by the CAMS Innovation Fund for Medical Science(CIFMS 2016-I2M-1-014);the National Key Plan for Scientific Research and Development of China(2016YFD0500300);National Key R&D Program of China(2020YFA0707600);Beijing Municipal Science and Technology Project(Z201100001020005)。
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a devastating pandemic worldwide.Vaccines and antiviral drugs are the most promising candidates for combating this global epidemic,and scientists a...
关键词：SARS-CoV-2 Reverse genetics REPLICON Antiviral drugs Drug evaluation 
A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery被引量：6
《Virologica Sinica》2021年第5期913-923,共11页Yun-Yun Jin Hanwen Lin Liu Cao Wei-Chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing Fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo 
supported by Grants(the National Natural Science Foundation of China#32041002,#31971161,#31900546 and#81620108020);the Guangdong Science and Technology Department(#2019A1515011332);the Shenzhen Science and Technology Innovation Program(JSGG20200225150431472,JCYJ20190807160615255,JCYJ20190807153203560,and KQTD20180411143323605);supported by the Guangdong Zhujiang Leading Talents Programme and the National Tenthousand Talents Program。
SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far.Due to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined...
关键词：SARS-CoV-2 Reverse genetics REPLICON Antiviral drug screening 
Development of A MERS-CoV Replicon Cell Line for Antiviral Screening
《Virologica Sinica》2021年第4期730-735,共6页Jing Chen Bing-Jie Hu Kai Zhao Yun Luo Hao-Feng Lin Zheng-Li Shi 
This study was supported by the strategic priority research program of the Chinese academy of sciences(XDB29010101).
Middle East respiratory syndrome coronavirus(MERS-CoV)is the causative agent of a severe respiratory disease with a high mortality of~35%.The lack of approved treatments for MERS-CoV infection underscores the need for...
关键词：Middle East respiratory syndrome coronavirus(MERS-CoV) Replicon cell line Antiviral screening Luciferase reporter gene 
The Establishment of Infectious Clone and Single Round Infectious Particles for Coxsackievirus A10被引量：2
《Virologica Sinica》2020年第4期426-435,共10页Min Wang Jingjing Yan Liuyao Zhu Meng Wang Lizhen Liu Rui Yu Ming Chen Jingna Xun Yuling Zhang Zhigang Yi Shuye Zhang 
supported by the Shanghai Public Health Clinical Center(KY-GW2018-17);Shanghai Municipal Commission of Health and Family Planning(20174Y0099)。
Coxsackievirus A10(CVA10)is one of the major etiological agents of hand,foot,and mouth disease.There are no vaccine and antiviral drugs for controlling CVA10 infection.Reverse genetic tools for CVA10 will benefit its ...
关键词：Coxsackievirus A10(CVA10) Reverse genetics ENTEROVIRUS Single round infectious particles(SRIPs) REPLICON 
Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway
《World Journal of Hepatology》2016年第19期796-814,共19页Miriam Triyatni Edward A Berger Bertrand Saunier 
Supported by Intramural Program of the National Institutes of Health,National Institute of Allergy and Infectious Diseases(Project No.1 ZIA AI000733-15:Enveloped Virus Glycoprotein/Receptor Interactions)to Edward A Berger,PhD(MSS,LVD,DIR,NIAID);ORISE Senior Fellow award(Award No.1238-1238-03:Department of Energy/Oak Ridge Institute for Science and Education)to Bertrand Saunier,MD,PhD
AIM: To determine if calnexin(CANX), RAB1 and alphatubulin were involved in the production of hepatitis C virus(HCV) particles by baby hamster kidney-West Nile virus(BHK-WNV) cells. METHODS: Using a si RNA-based appro...
关键词：Membrane rearrangements Hepatitis C virus Flavivirus replicon Virus assembly and secretion Host cellular factors 
Tricistronic hepatitis C virus subgenomic replicon expressing double transgenes
《World Journal of Gastroenterology》2014年第48期18284-18295,共12页Xin Cheng Xiang-Cui Gao Jun-Ping Wang Xin-Ying Yang Yan Wang Bao-Sheng Li Fu-Biao Kang Hai-Jun Li Yue-Min Nan Dian-Xing Sun 
Supported by Grants from the Study on Prevention and Control of Viral Hepatitis in the Key Program for Science and Technology Development of Hebei Province,No.10276102D
AIM: To construct a tricistronic hepatitis C virus (HCV) replicon with double internal ribosome entry sites (IRESes) of only 22 nucleotides for each, substituting the encephalomyocarditis virus (EMCV) IRESes, which ar...
关键词：HEPACIVIRUS REPLICON Internal ribosome entry site Tricistronic expression 
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