HETERODUPLEX

作品数：7被引量：9H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：杨洋吕照江杜涛许彩民傅新容更多>>
相关机构：中国医学科学院北京协和医学院北京协和医院更多>>
相关期刊：《Open Journal of Medical Microbiology》《Chemical Research in Chinese Universities》《眼科学报》《Engineering》更多>>
相关基金：美国中华医学基金会项目卫生部科技专项基金国家自然科学基金国家重点基础研究发展计划更多>>
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Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in a Macrophage-Specific and Liver-Specific Manner
《Engineering》2024年第10期189-203,共15页Hengdong Qu Di Zhang Junli Liu Jieping Deng Ruoyan Xie Keke Zhang Hongmei Li Ping Tao Genshu Wang Jian Sun Oscar Junhong Luo Chen Qu Wencai Ye Jian Hong 
supported by the Key-Area Research and Development Program of Guangdong Province(2020B1111110004);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);the Guangdong Major Project of Basic and Applied Basic Research(2023B0303000004);the National Natural Science Foundation of China(81871987,82293680,82293681,and 82273154);the Guangdong Basic and Applied Research Foundation(2023A1515012905 and 2022A1515012581)。
Nonalcoholic steatohepatitis(NASH)may soon become the leading cause of end-stage liver disease worldwide with limited treatment options.Liver fibrosis,which is driven by chronic inflammation and hepatic stellate cell(...
关键词：Pyruvate kinase M2 MACROPHAGES Nonparenchymal cells Heteroduplex oligonucleotide Nonalcoholic steatohepatitis Liver fibrosis 
A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals：A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis被引量：4
《Journal of Genetics and Genomics》2016年第5期341-348,共8页Vanessa Chenouard Lucas Brusselle Jean-Marie Heslan Séverine Remy Séverine Ménoret Claire Usal Laure-Hélène Ouisse Tuan Huy NGuyen Ignacio Anegon Laurent Tesson 
supported by the fundings from the Region Pays de la Loire through Biogenouest,the IBiSA Program,Fondation Progreffe;the French Government through the "Investissement d'avenir" program "TEFOR" project,managed by the National Research Agency(No.ANR-II-INSB-0014);the context of the "Investissement d'avenir" program LabEX IGO of the IHU-CESTI projects managed by the National Research Agency(Nos.ANR-11-LABX-001601 and ANR-10-IBHU-005,respectively)
The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various targeted genome editions in a wide range of species.Moreover...
关键词：Genome editing Genotyping Heteroduplex mobility assay Capillary electrophoresis 
A Simple LDT-PCR Method for Detection of Various Nucleic Acid Sequence Changes in a Small Region of Genes—Application for the Identification of Gene Mutations in MTB <i>rpoB</i>Gene Associated with Drug Resistance
《Open Journal of Medical Microbiology》2013年第3期172-177,共6页Xing Tang Steven Wood Larissa Baeva 
A modified low denaturing temperature PCR (LDT-PCR) method combined with DNA microarray technique is developed in our lab for quick and effective identification of various mutations in an 81 base pair region of Mycoba...
关键词：Low Denaturing Temperature PCR (LDT-PCR) Mycobacterium Tuberculosis (MTB) Ribosome RNA Polymerase Subunit B (rpoB) Drug Resistance Homoduplex HETERODUPLEX Microarray 
Photophysical Behavior of Heteroduplexes Formed from Naphthalene Incorporated Foldamers,and Linear Donors and Pyromellitic Diimide Incorporated Foldamers被引量：1
《Chemical Research in Chinese Universities》2009年第3期317-327,共11页ZHAO Shu-min GU Hai-ning ZHOU Qi-zhong 
Supported by the Ministry of Science and Technology of China(No.G2000078101);the National Natural Science Foun-dation of China(No.20172069)
The authors synthesized the electron-rich 1,5-dioxonaphthyl group incorporated foldamers, and linear donors and electron-deficient pyromellitic diimide incorporated foldamers, which were investigated in organic solven...
关键词：HETERODUPLEX Foldarner Linear donor Charge transfer Quench 
应用PCR-Heteroduplex银染法检测阵发性睡眠性血红蛋白尿症PIG-A基因突变被引量：2
《中华血液学杂志》1997年第10期551-552,共2页许彩民 杜涛 杨洋 傅新容 吕照江 陈忠雷 张之南 潘华珍 
卫生部基金;CMB基金
应用ＰＣＲ－Ｈｅｔｅｒｏｄｕｐｌｅｘ银染法检测阵发性睡眠性血红蛋白尿症ＰＩＧ－Ａ基因突变许彩民杜涛杨洋傅新容吕照江陈忠雷张之南潘华珍多聚酶链反应－异源双链分析（ＰＣＲ－Ｈｅｔｅｒｏｄｕｐｌｅｘ）是一种简便、灵敏的基因...
关键词：血红蛋白尿症 PNH PCR PIG-A 基因突变 
Exon-by-exon Screening for RB Germline Mutations Using Heteroduplex-SSCP Analysis被引量：1
《眼科学报》1997年第1期5-11,共7页Qingjiong Zhang, Kensei Minoda, Ruiping Zeng, Zhongyao Wu Xueshan Xiao, Shiqiang Li, Fengshen ZhangZhongshan Ophthalmic Center Department of Medica GeneticsSun Yat-sen University of Medical Sciences , Guangzhou 510060 , ChinaDepartment of Ophthalmology, Teikyo University Ichihara Hospital, Ichihara , Chiba 299 - 01, Japan. 
Guang Dong Provincial Natural Science Foundation (QZ:930354, 960149 );the Misnistry of Public Health(QZ);the Ministry of Health and Welfare of Japan(KM);the Mishima Fund for Eye Research and International Exchange(QZ);the Sasagawa Medical Re
Objective: To disclose the nature of RBI germline mutations in Chinese and to develop a practical and effective way for mutational screening. Methods: Leukocyte DNA was prepared from 8 Chinese patients with hereditary...
关键词：成视网膜细胞瘤 突变 SSCP 遗传因素 非遗传因素 
Detection of RB Germline Mutations Using Exon-by-exon Heteroduplex Analysis Compared with SSCP被引量：1
《Eye Science》1996年第3期151-157,共7页Kensei Minoda 
Purpose: To compare heteroduplex analysis with SSCP and to develop a simple and effective method for mutational screening of RB gene.Materials and Methods: Leukocyte DNA was prepared from 12 unrelated Japanese patient...
关键词：RETINOBLASTOMA gene MUTATION SSCP HETERODUPLEX 
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