THIOREDOXIN-1

作品数:6被引量:13H指数:2
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相关领域:医药卫生更多>>
相关作者:王孟飞孙晓艳殷竹鸣杭志强黄维荪更多>>
相关机构:中国医学科学院中国协和医科大学重庆医科大学南京医科大学南京大学更多>>
相关期刊:《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《神经药理学报》《中国地方病防治》《Cell Research》更多>>
相关基金:国家自然科学基金江苏省临床医学科技专项更多>>
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Thioredoxin-1 and Geranylgeranylacetone Resist Neurotoxicity of Amyloid-β
《神经药理学报》2019年第4期15-64,共50页BAI Li-ping LI Ye ZHOU Xiao-shuang ZHANG Xian-wen SUN Bo YAN Chen DENG Ru-hua BAI Jie 
Objective:Alzheimer’s disease( AD) is the most common neurodegenerative disorder which is characterized by amyloid-β( Aβ) aggradation in the brain and impairment of cognitive function. Thioredoxin-1( Trx-1) is a re...
关键词:THIOREDOXIN-1 Alzheimer’s disease GERANYLGERANYLACETONE amyloid-β APP/PS1 cognitive function 
Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1被引量:5
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第10期750-763,共14页Yan-yan SHI Jing ZHANG Ting ZHANG Man ZHOU Ye WANG He-jun ZHANG Shi-gang DING 
Project supported by the Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases,Beijing Key Laboratory(No.BZ0371);the National Natural Science Foundation of China(Nos.81700496,81270475,and 30770980)
Heficobacterpylori infection is related to the development of gastric diseases. Our previous studies showed that high thioredoxin-1 (Trxl) expression in H. pylori can promote gastric carcinogenesis. To explore the u...
关键词:Thioredoxin-1 (Trxl) Heficobacter pylori Gastric carcinogenesis PROTEOMICS Isobaric tags for relativeand absolute quantitation (iTRAQ) 
Thioredoxin-1在乳腺癌的表达及临床意义的研究
《中国地方病防治》2017年第12期1389-1389,共1页黄维荪 管晓翔 刘超英 许隽颖 杭志强 
江苏省临床医学科技专项[BL2014071]
乳腺癌是一种严重危害女性生命健康的恶性肿瘤,位于女性肿瘤发病率第一位。近年来,乳腺癌的治疗和诊断取得了很大进展,但复发及预后较差,因此亟需探究乳腺癌的发生、发展机制。硫氧还蛋白-1(Thioredoxin-1)可促进非小细胞肺癌中...
关键词:乳腺癌 临床意义 非小细胞肺癌 恶性肿瘤 女性肿瘤 硫氧还蛋白 发病率 过表达 
Effects of Hyperoxia on Cytoplasmic Thioredoxin System in Alveolar Type Epithelial Cells of Premature Rats
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第2期258-263,共6页单瑞艳 常立文 李文斌 刘伟 容志惠 陈燕 曾凌空 
supported by a grant from the National Natural Sciences Foundation of China (No. 30770944)
This study investigated the effects of hyperoxia on dynamic changes of thioredoxin-1 (Trx1) and thioredoxin reductase-1 (TrxR1) in alveolar type Ⅱ epithelial cells (AECⅡ) of premature rats. Pregnant Sprague-Da...
关键词:HYPEROXIA THIOREDOXIN-1 thioredoxin reductase-1 lung injury alveolar type  epithelial cell apoptosis premature rats 
Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death被引量:7
《Cell Research》2008年第4期458-471,共14页Changhai Tian Ping Gao Yanhua Zheng Wen Yue Xiaohui Wang Haijing Jin Quan Chen 
lntracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, i...
关键词:THIOREDOXIN-1 arsenic trioxide MITOCHONDRIA cytochrome c APOPTOSIS 
Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice被引量:1
《Cell Research》2006年第2期230-239,共10页Aoi Son Hajime Nakamura Norihiko Kondo Yoshiyuki Matsuo Wenrui Liu Shin-ichi Oka Yasuyuki lshii Junji Yodoi 
Thioredoxin-1 (TRX) is a stress-inducible redox-regulatory protein with antioxidative and anti-inflammatory effects. Here we show that the release of histamine from mast cells elicited by cross-linking of high-affin...
关键词:THIOREDOXIN redox mast cell histamine release ALLERGY 
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