Objective:Alzheimer’s disease( AD) is the most common neurodegenerative disorder which is characterized by amyloid-β( Aβ) aggradation in the brain and impairment of cognitive function. Thioredoxin-1( Trx-1) is a re...
Project supported by the Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases,Beijing Key Laboratory(No.BZ0371);the National Natural Science Foundation of China(Nos.81700496,81270475,and 30770980)
Heficobacterpylori infection is related to the development of gastric diseases. Our previous studies showed that high thioredoxin-1 (Trxl) expression in H. pylori can promote gastric carcinogenesis. To explore the u...
supported by a grant from the National Natural Sciences Foundation of China (No. 30770944)
This study investigated the effects of hyperoxia on dynamic changes of thioredoxin-1 (Trx1) and thioredoxin reductase-1 (TrxR1) in alveolar type Ⅱ epithelial cells (AECⅡ) of premature rats. Pregnant Sprague-Da...
lntracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, i...
Thioredoxin-1 (TRX) is a stress-inducible redox-regulatory protein with antioxidative and anti-inflammatory effects. Here we show that the release of histamine from mast cells elicited by cross-linking of high-affin...