CELASTROL

作品数：55被引量：194H指数：9
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相关机构：南昌大学第一附属医院中山大学南京师范大学广州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划广东省自然科学基金更多>>
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Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress Author links open overlay panel
《Journal of Traditional Chinese Medical Sciences》2024年第3期330-339,共10页Jiajian Guo Dongxiao Cui Yuping Tang Sanjiao Wang Cuiyan Ma Wenfu Ma 
supported by grants from startup fund program at Beijing University of Chinese Medicine(90011451310011);key research fund for drug discovery in Chinese medicine at Beijing University of Chinese Medicine(1000061223476);startup fund program at Beijing University of Chinese Medicine(90020361220006).
Objective:To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved,specifically focusing on the role of the caspase-3/gasdermin E(GSDME)signaling path...
关键词：CELASTROL Tumor cells PYROPTOSIS GSDME CASPASE-3 Endoplasmic reticulum stress stress Cell death Traditional Chinese medicine 
Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils被引量：2
《Journal of Traditional Chinese Medical Sciences》2017年第1期50-58,共9页Kai Yuan Guangrui Huang Shan Zhang Qingqing Zhu Ruipeng Yu Honghao Sheng Guangbin Luo Anlong Xu 
the National Natural Science Foundation of China(Grant number 81430099);International S&T Cooperation Program of China(Grant number 2014DFA32950);Beijing Municipal Commission of Education(Grant number 521/0101312).
Objective:Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA).In this study,we used the adjuvant-induced arthritis murine model to evaluate the efficacy of celastrol on neutrophil-media...
关键词：RHEUMATOID ARTHRITIS NEUTROPHILS CELASTROL 
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